Hypolipidemic and Antioxidative Effects of the Plant Glycoprotein (36 kDa) from<i>Rhus verniciflua</i>Stokes Fruit in Triton WR-1339-Induced Hyperlipidemic Mice

Oh, Phil-Sun; Lee, Sei-Jung; Lim, Kye-Taek

doi:10.1271/bbb.70.447

Cited by 63 publications

(45 citation statements)

References 35 publications

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“…It is widely used, particularly in mice, for screening natural or chemical hypolipidemic drugs [16,[19][20]. In the present study, TC and TG levels were largely elevated 24 h after the triton WR-1339 administration, which was significantly decreased by the treatment with CAE.…”

Section: Discussionsupporting

confidence: 51%

Hypolipidemic effect of aqueous leaf extract of carmona microphylla G Don

Liu¹,

Lin²,

Yu³

et al. 2016

Trop. J. Pharm Res

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Purpose: To investigate the hypolipidemic effects of the aqueous leaf extract of Carmona microphylla (Lam.) G. Don. (CAE) in vitro and in vivo. Methods: The lipid-lowering effect of CAE was investigated in oleic acid (OA)-induced steatosis in HepG2 liver cells, as well as in high-fat diet (HFD)-and triton WR-1339 (TRI)-induced hyperlipidemic mice. The levels of intracellular, serum and/or hepatic total cholesterol (TC); triglyceride (TG); low density lipoprotein-cholesterol (LDL-c); high density lipoprotein-cholesterol (HDL-c); hepatic superoxide dismutase (SOD) activity and malondialdehyde (MDA) were determined by oil-red O staining and appropriate kits. Results: Treatment with CAE inhibited lipid accumulation in HepG2 cells and reduced the elevated levels of serum TC, TG and LDL-c as well as hepatic TC and TG in hyperlipidemic mice induced by HFD. CAE administration also significantly decreased arteriosclerosis index (AI) and LDL-c/HDL-c ratio

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Section: Discussionsupporting

confidence: 51%

Hypolipidemic effect of aqueous leaf extract of carmona microphylla G Don

Liu¹,

Lin²,

Yu³

et al. 2016

Trop. J. Pharm Res

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“…Dietary supplementation of SFP up to 15 g/kg for 90 days decreased TC in rabbits (Capcarova et al, 2011). In an experiment, consumption of 100 mg glycoprotein/kg isolated from Rhus verniciflua stokes fruit (another sumac species) for two weeks caused decreased TC, triglyceride (TG) and low density lipoprotein (LDL-c) concentrations in mice (Oh et al, 2006). Although the plasma cholesterol lowering effects of SFP have been shown in rabbits and mice, no study is available on the effect of SFP on blood TC, TG, plasma fasting blood sugar (FBS) and other blood lipoproteins and even the performance of broiler chickens.…”

Section: Introductionmentioning

confidence: 99%

Dietary <i>Rhus coriaria</i> L. powder reduces the blood cholesterol, VLDL-c and glucose, but increases abdominal fat in broilers

Golzadeh¹,

Farhoomand²,

Daneshyar³

2012

SA J. An. Sci.

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In an experiment, 200 one-day-old broiler chickens (Ross 308) were used to investigate the effects of sumac fruit (Rhus coriaria L.) powder (SFP) on performance, plasma concentrations of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-c), low density lipoprotein (LDL-c), very low density lipoprotein (VLDL-c) and plasma fasting blood sugar (FBS), as well as proportional abdominal fat. The chicks were divided into four treatment groups with 5 replicates and 10 birds in each. The birds were fed the basal diet (Z-SFP) or diets supplemented with 2.5 g SFP (L-SFP), 5 g SFP (M-SFP) and 10 g SFP (H-SFP) per kg diet. During the whole experimental period the H-SFP birds had a higher feed intake than the Z-SFP and L-SFP birds, though the H-SFP birds had higher feed conversion ratio compared with birds in the other treatments. No significant differences for body weight gain were recorded between the treatments. The M-SFP and H-SFP birds had lower plasma TC and VLDL-c concentrations than the Z-SFP and L-SFP birds. No significant differences between the treatments were indicated for plasma TG, HDL-c and LDL-c concentrations. Moreover the plasma FBS concentration of the H-SFP birds was lower than the birds in treatments Z-SFP and L-SFP, but no significant differences were observed between the other treatments. Furthermore, significant negative correlations were found between SFP supplementation and plasma TC, VLDL-c and FBS concentrations and a significant positive correlation between SFP supplementation and abdominal fat weight. In conclusion, dietary supplementation of SFP reduces the blood TC, VLDL-c and FBS concentrations, which can be related to decreased activity of HMG-CoA reductase and α-amylase activities. The higher abdominal fat weight of the SFP-fed birds is possibly related to changes of energy storage towards fat deposition. ________________________________________________________________________________

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“…In the present study, Triton WR-1339 administration increased the oxidative stress biomarker MDA, and decreased the activity and mRNA expression of antioxidant enzymes (catalase, SOD, glutathione reductase and GST). It has been shown that 18 hours after Triton WR-1339 administration, the level of plasma ROS were increased and the activity of catalase and GPx were decreased compared to control group [28,45]. In this study, those alterations were normalized by administration of mushroom, chrysin, curcumin and omega-3 as did simvastatin.…”

Section: Discussionmentioning

confidence: 46%

Antihypercholesterolemic Effects of Mushroom, Chrysin, Curcumin and Omega-3 in Experimental Hypercholesterolemic Rats

Ismail¹,

Soliman²,

Nassan³

et al. 2015

JFNR

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Hypercholesterolemia and hypertriglyceridemia are major risk factors that accelerate the incidence of atherosclerosis and coronary artery diseases. Therefore, the present study was conducted to evaluate the hypolipidemic effect of widely known traditional medicinal herbs and omega-3 FA in experimental hypercholesterolemia induced by Triton WR-1339. Experimental hypercholesterolemic rats were administered mushroom, chrysin, curcumin and omega-3 for 2 weeks. Hypercholesterolemic rats showed an increase in serum levels of lipid profiles and hepatic enzymes. Hypercholesterolemic rats showed an increase in malondialdehyde (MDA) levels and a decrease in both serum levels and mRNA expression of catalase, superoxide dismutase (SOD) and glutathione reducatse. Moreover, hypercholesterolemic rats showed hepatic down regulation in the expression of genes related to fatty acids oxidation such as acyl CoA oxidase (ACO) and synthetase (ACS), together with carnityl palmityl transferase-1 (CPT-1) and peroxisome proliferator activator receptor-α (PPAR-α). Administration of mushroom, chrysin, curcumin and omega-3 to hypercholesterolemic rats for 2 weeks up-regulated significantly the down regulated genes. In contrast, expression of genes related to fatty acids biosynthesis and cholesterol metabolism were increased in hypercholesterolemic rats compared to control group. Herbal medications and omega-3 administration down regulated genes of fatty acids biosynthesis and cholesterol metabolism to normal expression. At cellular levels, hyperlipidemia induced fatty droplets accumulation, necrosis and presence of apoptotic hepatocytes together with leukocytic infiltration in necrotic area that are ameliorated and normalized after administration of herbs and omega-3. In conclusion, the current findings indicated that flavonoids (mushroom, chrysin, curcumin) and omega-3 possess antihypercholesterolemic effects at biochemical, molecular and histopathological levels and are useful in treatment of hypercholesterolemia with lower side effects compared with synthetic hypolipidemic drugs.

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Hypolipidemic and Antioxidative Effects of the Plant Glycoprotein (36 kDa) fromRhus vernicifluaStokes Fruit in Triton WR-1339-Induced Hyperlipidemic Mice

Cited by 63 publications

References 35 publications

Hypolipidemic effect of aqueous leaf extract of carmona microphylla G Don

Hypolipidemic effect of aqueous leaf extract of carmona microphylla G Don

Dietary <i>Rhus coriaria</i> L. powder reduces the blood cholesterol, VLDL-c and glucose, but increases abdominal fat in broilers

Antihypercholesterolemic Effects of Mushroom, Chrysin, Curcumin and Omega-3 in Experimental Hypercholesterolemic Rats

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