Hypolipidemic and cardioprotective effects of<i>Ulva lactuca</i>ethanolic extract in hypercholesterolemic mice

Kammoun, Intissar; Salah, Hichem Ben; Saad, Hajer Ben; Cherif, Boutheina; Droguet, Mickaël; Magné, Christian; Kallel, Choumous; Boudawara, Ons; Hakim, Ahmed; Gharsallah, Néji; Amara, Ibtissem Ben

doi:10.1080/13813455.2017.1401641

Cited by 18 publications

(17 citation statements)

References 52 publications

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“…Treatment of hypercholesterolemic mice with U. lactuca extract (250 mg/kg body weight) for 4 weeks revealed a cardioprotective effect by improving heart oxidative stress, plasma biochemical parameters, and index of atherogenesis. Additionally, a reduction in gene expression of proinflammatory cytokines (TNFα, IL-1β and IL-6) in the heart of U. lactuca -supplemented animals was also observed [ 225 ]. Kappaphycus alvarezii , a red seaweed, was tested as a food supplement to prevent diet-induced MetS in rats.…”

Section: Bioactive Properties Of Marine Phenolicsmentioning

confidence: 99%

Bioactive Properties of Marine Phenolics

2020

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Phenolic compounds from marine organisms are far less studied than those from terrestrial sources since their structural diversity and variability require powerful analytical tools. However, both their biological relevance and potential properties make them an attractive group deserving increasing scientific interest. The use of efficient extraction and, in some cases, purification techniques can provide novel bioactives useful for food, nutraceutical, cosmeceutical and pharmaceutical applications. The bioactivity of marine phenolics is the consequence of their enzyme inhibitory effect and antimicrobial, antiviral, anticancer, antidiabetic, antioxidant, or anti-inflammatory activities. This review presents a survey of the major types of phenolic compounds found in marine sources, as well as their reputed effect in relation to the occurrence of dietary and lifestyle-related diseases, notably type 2 diabetes mellitus, obesity, metabolic syndrome, cancer and Alzheimer’s disease. In addition, the influence of marine phenolics on gut microbiota and other pathologies is also addressed.

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Section: Bioactive Properties Of Marine Phenolicsmentioning

confidence: 99%

Bioactive Properties of Marine Phenolics

2020

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“…Increased reactive oxygen species and inflammation constitute the leading causes of the soaring rates of metabolic diseases such as atherosclerosis and diabetes (Yuan et al, 2019). The search for safe and efficacious approaches to combat continuously expanding oxidative stress, inflammation, and diabetes from natural products has emerged as a crucial strategy because they contain diverse biologically active compounds (Kammoun et al, 2018;Tong et al, 2015). Seaweeds, a promising marine resource, have been exploited and utilized traditionally as food supplements and for various medicinal purposes in Korea, China, Japan, and other Asian countries.…”

Section: Introductionmentioning

confidence: 99%

“…Ulva lactuca, also known as sea lettuce, is characterized by a high content of carbohydrates, proteins, lipids, fiber, minerals, chlorophyll b, carotenoids, and other nutrients (Kammoun et al, 2018) and is greatly consumed in East Asia. It has good adaptability to different climates, high growth rates, high biomass per acre yield, and negligible requirements for fresh water (Mhatre et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…It has good adaptability to different climates, high growth rates, high biomass per acre yield, and negligible requirements for fresh water (Mhatre et al, 2019). This marine seaweed is reported to have several pharmacological properties, including chemopreventive, hypolipidemic, and cardioprotective effects (Delgado-Roche et al, 2019;Hassan et al, 2011;Kammoun et al, 2018). For instance, the aqueous-ethanolic extract of U. lactuca inhibits the activity and expression of hepatic cytochrome P450 1A1 in mice exposed to benzo(a)pyrene (Delgado-Roche et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant, anti-inflammatory, and α-amylase inhibitory activities of Ulva lactuca extract

Tong¹,

Liu²,

Zhang³

et al. 2020

Korean J. Food Preserv.

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In this study, an extract of Ulva lactuca was investigated for its in vitro antioxidant activities (2,2-diphenyl-1-picrylhydrazyl radical, hydroxyl radical, and superoxide anion radical scavenging activity, and reducing power) and enzyme inhibitory activities (α-amylase and α-glucosidase). The anti-inflammatory effect of U. lactuca extract was evaluated in lipopolysaccharide-stimulated RAW 264.7 cells, a widely used macrophage cell line. We observed that U. lactuca extract contained a relatively high total phenolic content (7.72 mg of gallic acid equivalents/g of extract) and exhibited multiple antioxidant activities including the scavenging of 2,2-diphenyl-1-picrylhydrazyl radical, hydroxyl, and superoxide anion radicals as well as reducing power. Simultaneously, we found that U. lactuca extract exhibited anti-inflammatory activity as evidenced by the reduction of nitric oxide in the U. lactuca extract-treated RAW 264.7 cells. Moreover, U. lactuca extract had a moderate inhibitory effect on α-amylase, although it showed no obvious inhibitory effect on α-glucosidase at the concentration tested. Collectively, our results demonstrated that the phenolic-enriched U. lactuca extract exhibited antioxidant and anti-inflammatory activities, and inhibited enzyme (α-amylase) relevant to hyperglycemia. Further research is required to determine the potential of developing the U. lactuca extract as a nutraceutical or pharmaceutical ingredient.

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“…Ulvan extracted from the algae showed cytotoxic activity (Thanh et al, 2016) while the aqueous ethanolic extract showed chemoprotective effect (Delgado-Roche et al, 2019). Ethanolic extract also showed hypolipidemic and cardioprotective effects (Kammoun et al, 2018). Ulva lactuca has a great potential antioxidant activity because it is considered as a potential rich source of natural colorant (El-Baky et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical, antioxidant, and anti-inflammatory screening of the Egyptian Ulva lactuca methanolic extract

Zaatout

Ghareeb

Abd-Elgwad

et al. 2019

Records of Pharmaceutical and Biomedical Sciences

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Ulva lactuca is widespread green alga. In some regions, it is used in nutrition. Its nutrients include iron, protein, iodine, vitamins (A, B1 and C) and trace elements. Ulva extracts showed potential antibacterial, hypolipidemic, cardioprotective and chemoprotective activities. Phytochemical investigation of the Egyptian Ulva lactuca methanolic crude extract/fractions were assessed by measuring total phenolics, flavonoids, alkaloids, carbohydrates, lipids, proteins and amino acids content. Biologically guided fractionation of plants or seaweeds extracts is considered the first step in drug discovery. So, the algal crude extract was fractionated then in vitro bioscreened for the determination of diphenylpicrylhydrazyl (DPPH) antioxidant, NO radical scavenging and antiinflammatory activities. Results showed that water fraction was the most active fraction so it was subjected to further phytochemical investigation. Phenolic content, detected from HPLC, play a role in the antioxidant activity. Finally, it can be concluded that Ulva water fraction is effective candidate to be used in the treatment of oxidative stress and related disorders.

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Hypolipidemic and cardioprotective effects ofUlva lactucaethanolic extract in hypercholesterolemic mice

Abstract: It was established that the green alga, thanks to its bioactive compounds, effectively counteracts cardiotoxic effects of hypercholesterolemic regime.

Cited by 18 publications

References 52 publications

Bioactive Properties of Marine Phenolics

Bioactive Properties of Marine Phenolics

Antioxidant, anti-inflammatory, and α-amylase inhibitory activities of Ulva lactuca extract

Phytochemical, antioxidant, and anti-inflammatory screening of the Egyptian Ulva lactuca methanolic extract

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