Hypolipidemic and hepatoprotective activities of rosemary and thyme in gentamicin-treated rats

Hegazy, Amany M.; Abdel-Azeem, A. A. S.; Zeidan, Hala; Ibrahim, K.; El-Sayed, E. M.

doi:10.1177/0960327117710534

Cited by 31 publications

(24 citation statements)

References 46 publications

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“…sore throat [ 162 , 163 ], skin inflammation [ 163 ], digestive and prokinetic [ 163 , 164 , 165 ], kidney problems [ 163 , 165 , 166 , 167 ], and anti-inflammatory [ 163 , 165 , 168 ]; Thymus spp. hypolipidaemic [ 144 ], balsamic and expectorant [ 169 , 170 , 171 , 172 ], and anti-inflammatory [ 170 , 171 ]; Urtica dioica hypolipidaemic, anti-atherosclerosis, hepatoprotective, and diuretic [ 173 , 174 ], anti-inflammatory, rheumatic pains, and contusions [ 65 , 173 , 174 , 175 , 176 ]; Vaccinium myrtillus maintenance of ocular health and function [ 146 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 ] (this last activity is refuted by a systematic review from 2004 [ 185 ]), improving of blood circulation [ 146 , 178 , 183 , 186 ], and maintaining of urinary tract health [ 187 ]; Vaccinium vitis-idaea maintaining of ocular health and function [ 180 , 181 ] and maintaining of urinary tract health [ ...…”

Section: Resultsmentioning

confidence: 99%

Using Medicinal Plants in Valmalenco (Italian Alps): From Tradition to Scientific Approaches

et al. 2020

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This ethnobotanical survey was carried out in Caspoggio (Valmalenco, SO, Italy) with the purpose of investigating the traditional uses of medicinal plants. Moreover, a bibliographic research meant to validate or refute the uses, focusing on the potentially responsible compounds, was performed. Fifty-nine species, attributable to 30 families (Asteraceae, Pinaceae, Malvaceae, and Lamiaceae the most cited), were mentioned. Arnica montana, anti-inflammatory for traumas and musculoskeletal pains; Pinus mugo, expectorant; Malva sylvestris, anti-inflammatory and soothing; Achillea moschata, digestive. The compounds, responsible for the therapeutic activities, are often polyphenols and terpenoids: helenanin in A. montana, α-pinene, δ-3-carene, and limonene in P. mugo, gossypin and malvin in M. sylvestris, luteolin and apigenin in A. moschata. Scientific evidence for at least one of the traditional activities described was found for 50 species but only in 26 out of 196 works consulted, it is possible to make a comparison between investigated extracts and traditional preparations. This study is thus a stimulus to new phytochemical investigations, mimicking as much as possible the traditional preparations. This work is part of the European Interreg Italy-Switzerland B-ICE project, aimed at creating a management model for the ongoing climate change and searching for new sources of territory valorization as attractions for tourists.

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Section: Resultsmentioning

confidence: 99%

Using Medicinal Plants in Valmalenco (Italian Alps): From Tradition to Scientific Approaches

et al. 2020

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“…The toxicity caused by gentamicin was attenuated in Sprague-Dawley rats with administration of R. officinalis L. extract [60]. In this study, the animals received gentamicin by intraperitoneal injection and 8% R. officinalis L. aqueous extract orally (10 mL/kg), the control groups were treated with saline solution (0.9% NaCl) or gentamicin (60 mg/kg).…”

Section: Control Of Body Weight and Dyslipidemiamentioning

confidence: 99%

“…These molecules are responsible for exerting significant antioxidant activity, as well as quercitin, luteolin, kaempferol, and rosmarinic, hydrocafeic and caffeic acids [61]. Thus, R. officinalis L. can protect the organism against hyperlipidemic and hepatotoxic effects promoted by some products, as gentamicin [60]. This antibiotic can affect the liver and enhance the enzymatic activity of aspartate transaminase (AST) and alanine transaminase (ALT), as well as increase the bilirubin level and decrease the protein synthesis.…”

Section: Control Of Body Weight and Dyslipidemiamentioning

confidence: 99%

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Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent

2019

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Rosmarinus officinalis L. (rosemary) is a medicinal plant native to the Mediterranean region and cultivated around the world. Besides the therapeutic purpose, it is commonly used as a condiment and food preservative. R. officinalis L. is constituted by bioactive molecules, the phytocompounds, responsible for implement several pharmacological activities, such as anti-inflammatory, antioxidant, antimicrobial, antiproliferative, antitumor and protective, inhibitory and attenuating activities. Thus, in vivo and in vitro studies were presented in this Review, approaching the therapeutic and prophylactic effects of R. officinalis L. on some physiological disorders caused by biochemical, chemical or biological agents. In this way, methodology, mechanisms, results, and conclusions were described. The main objective of this study was showing that plant products could be equivalent to the available medicines.

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“…Among the herbs belonging to the Lamiaceae family, rosemary (Rosmarinus officinalis L.) is by far the one to which the highest number of biological activities have been ascribed. In the latest five years, the in-vivo hepato-and hepato-renal protective effects of rosemary have been extensively studied; as example Hegazy et al [426] investigated the preventive effect of the aqueous extract of this herb on the gentamicininduced hepatotoxicity in rats with promising result connecting these activities with the presence in the extract of catechin (37), coumarin (38), cinnamic acid (39), rutin (40), sinapic acid (41) and oleuropein (42), whilst Mohamed et al [427] studied the protection of rosemary ethanolic extract on lead acetate hepatoand nephrotoxicity in male albino rabbits. The authors found that pre-treatment with rosemary extract significantly suppressed levels of hepatic and renal damage products as well as lipid peroxidation.…”

Section: Rosemarymentioning

confidence: 99%

New Tricks for Old Guys: Recent Developments in the Chemistry, Biochemistry, Applications and Exploitation of Selected Species from the Lamiaceae Family

Napoli

Siracusa

Ruberto

2020

Chemistry & Biodiversity

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Lamiaceae is one of the largest families of flowering plants comprising about 250 genera and over 7,000 species. Most of the plants of this family are aromatic and therefore important source of essential oils. Lamiaceae are widely used as culinary herbs and reported as medicinal plants in several folk traditions. In the Mediterranean area oregano, sage, rosemary, thyme and lavender stand out for geographical diffusion and variety of uses. The aim of this review is to provide recent data dealing with the phytochemical and pharmacological studies, and the more recent applications of the essential oils and the non‐volatile phytocomplexes. This literature survey suggests how the deeper understanding of biomolecular processes in the health and food sectors as per as pest control bioremediation of cultural heritage, or interaction with human microbiome, fields, leads to the rediscovery and new potential applications of well‐known plants.

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Hypolipidemic and hepatoprotective activities of rosemary and thyme in gentamicin-treated rats

Cited by 31 publications

References 46 publications

Using Medicinal Plants in Valmalenco (Italian Alps): From Tradition to Scientific Approaches

Using Medicinal Plants in Valmalenco (Italian Alps): From Tradition to Scientific Approaches

Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent

New Tricks for Old Guys: Recent Developments in the Chemistry, Biochemistry, Applications and Exploitation of Selected Species from the Lamiaceae Family

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