Hypolipidemic effect of dihydroisoquinoline oxaziridine in high-fat diet-fed rats

Aydi, Rihab; Gara, Amel Ben; Chaaben, Rim; Saad, Hajer Ben; Fki, Lotfi; Elfeki, Abdelfattah; Belghith, Hafedh; Belghith, Karima; Kammoun, Majed

doi:10.1016/j.biopha.2016.06.003

Cited by 7 publications

(7 citation statements)

References 43 publications

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“…Although the initial event in lipid-induced kidney damage has not been defined, oxidative stress is recognized as one of the most significant pathogenic mechanisms. The inhibition of lipid deposition [20–22] and decreases in ROS and inflammation levels [23–25] could improve impaired kidney function. In the current study, in addition to increased body weight, insulin resistance, and dyslipidemia, the rats fed with the HFD showed higher oxidative stress levels and impaired renal function, which were reflected by biomarkers of early renal impairment, including serum cystatin C, urine NAG activity, microalbuminuria, and Ccr [26–28].…”

Section: Discussionmentioning

confidence: 99%

Green Tea Polyphenols Ameliorate the Early Renal Damage Induced by a High‐Fat Diet via Ketogenesis/SIRT3 Pathway

Xie

Du³

et al. 2017

Oxidative Medicine and Cellular Longevity

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Scope Several reports in the literature have suggested the renoprotective effects of ketone bodies and green tea polyphenols (GTPs). Our previous study found that GTP consumption could elevate the renal expression of the ketogenic rate-limiting enzyme, which was decreased by a high-fat diet (HFD) in rats. Here, we investigated whether ketogenesis can mediate renoprotection by GTPs against an HFD. Methods and Results Wistar rats were fed a standard or HFD with or without GTPs for 18 weeks. The renal oxidative stress level, kidney function, renal expression, and activity levels of mitochondrial 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase 2 (HMGCS2) and sirtuin 3(SIRT3) were detected. The increased renal oxidative stress and the loss of renal function induced by the HFD were ameliorated by GTPs. Renal ketogenesis and SIRT3 expression and activity levels, which were reduced by the HFD, were restored by GTPs. In vitro, HEK293 cells were transfected with the eukaryotic expression plasmid pcDNA HMGCS2. GTP treatment could upregulate HMGCS2 and SIRT3 expression. Although SIRT3 expression was not affected by HMGCS2 transfection, the 4-hydroxy-2-nonenal (4-HNE) level and the acetyl-MnSOD (K122)/MnSOD ratio were reduced in HMGCS2-transfected cells in the context of H2O2. Conclusion The ketogenesis/SIRT3 pathway mediates the renoprotection of GTPs against the oxidative stress induced by an HFD.

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Section: Discussionmentioning

confidence: 99%

Green Tea Polyphenols Ameliorate the Early Renal Damage Induced by a High‐Fat Diet via Ketogenesis/SIRT3 Pathway

Xie

Du³

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…The compound 23 a exhibited hypolipidemic effect in high-fat diet-fed rats. [25] The authors extended their study via incorporation of À NO 2 group in the aromatic ring of 22 to synthesize 25 via 24. The synthesized compounds (25) were employed to oxidize sulfides.…”

Section: N-sulfonyl Oxaziridines and Dihydroisoquinoline Oxaziridinesmentioning

confidence: 99%

“…[25] The authors extended their study via incorporation of À NO 2 group in the aromatic ring of 22 to synthesize 25 via 24. The synthesized compounds (25) were employed to oxidize sulfides. [26,27] It was revealed that due to the presence of trichloromethyl (23) and nitro groups (25) on the dihydroisoquinoline skeleton, the oxaziridine became more electrophilic and the reaction of oxygen transfer into sulphide occured in absence of acid (see section 3.1.2).…”

Section: N-sulfonyl Oxaziridines and Dihydroisoquinoline Oxaziridinesmentioning

confidence: 99%

“…In 2016, Kammoun and co‐workers synthesized dihydroisoquinoline oxaziridines 23 (R=CCl 3 , Scheme 8) from tertiary alcohol 21 following a two step process via 22 . The compound 23 a exhibited hypolipidemic effect in high‐fat diet‐fed rats [25] . The authors extended their study via incorporation of −NO 2 group in the aromatic ring of 22 to synthesize 25 via 24 .…”

Section: Direct Synthesis Of Oxaziridinesmentioning

confidence: 99%

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Recent Advances in the Preparations and Synthetic Applications of Oxaziridines and Diaziridines

et al. 2021

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Oxaziridines and diaziridines have been used as versatile intermediates due to their high ring strain as well as the reactive CÀ O/N bond, for the synthesis of diverse range of nitrogen containing compounds. In the past few decades, numerous novel and handy methodologies on the preparations and utilizations of both the oxaziridines and diaziridines have been developed. In spite of few published reviews in the area (almost a decade back), the synthetic communities have made tremendous progress in their preparations and utilizations. This review has demonstrated the comprehensive advancement in the chemistry of oxaziridines and diaziridines for the last few years (almost a decade). 2.4. Oxaziridines from Ketimines 3. Reactivities of Oxaziridines 3.1. Oxygen Atom Transfer Reactions 3.2. Nitrogen Atom Transfer Reactions 3.3. Rearrangement Reactions of Oxaziridines 3.4. Cycloaddition Reactions 4. Synthesis of Diaziridines 4.1. Diaziridines from Imine Substrates 4.2. Bi-Diaziridines and Monocyclic Diaziridines using Nosyloxycarbamate 4.3. Alkenyl Diaziridines 4.4. Diaziridines using HOSA Reagent 4.5. N-Cyclopropyl Diaziridines 4.6. Synthesis of Diaziridines via Photocatalysis 5. Reactivities of Diaziridines and its Derivatives 6. Diaziridines as Intermediates 7. Conclusions

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“…[19] Recently, dihydroisoquinoline oxaziridines have been shown to have potent hypolipidemic effect in high-fat diet-fed rats. [20] Furthermore, they are widely used as reagents and intermediates in the preparation of biologically active molecules [21][22][23] Nitrones were first used to trap free radicals in chemical systems and then subsequently in biochemical systems. More recently, several nitrones, including alpha-phenyl-tertbutylnitrone (PBN), have been shown to have potent biological activity in many experimental animal models.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structure study, and evaluation of antimicrobial and antibiofilm activities of a novel dihydroisoquinoline-derived

Selmi¹,

Kammoun

Mnif

et al. 2022

Journal of Molecular Structure

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Hypolipidemic effect of dihydroisoquinoline oxaziridine in high-fat diet-fed rats

Cited by 7 publications

References 43 publications

Green Tea Polyphenols Ameliorate the Early Renal Damage Induced by a High‐Fat Diet via Ketogenesis/SIRT3 Pathway

Green Tea Polyphenols Ameliorate the Early Renal Damage Induced by a High‐Fat Diet via Ketogenesis/SIRT3 Pathway

Recent Advances in the Preparations and Synthetic Applications of Oxaziridines and Diaziridines

Synthesis, crystal structure study, and evaluation of antimicrobial and antibiofilm activities of a novel dihydroisoquinoline-derived

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