Hypolipidemic Effect of <i>n</i>‐Butanol Extract from <i>Asparagus officinalis</i> L. in Mice fed a High‐fat Diet

Zhu, Xinglei; Zhang, Wen; Pang, Xiufeng; Wang, Jiesi; Zhao, Jingjing; Qu, Wei

doi:10.1002/ptr.3380

Cited by 24 publications

(19 citation statements)

References 22 publications

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“…Asparagus has been used in traditional Asian medicine since ancient times for its diuretic, antifatigue, and metabolism‐enhancement effects. Recent studies demonstrated that asparagus extract modulates blood glucose level in diabetic rats (Hafizur and others ) and has hypolipidemic action (Zhu and others ) as well as oxidant defense activity (Kim and others ). The current study was performed to identify the enhanced expression of intracellular heat shock protein 70 (HSP70) in response to a unique ETAS and its antistress effect.…”

Section: Resultsmentioning

confidence: 99%

Enzyme‐Treated Asparagus Extract Promotes Expression of Heat Shock Protein and Exerts Antistress Effects

Ito

Maeda

Goto

et al. 2014

Journal of Food Science

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A novel enzyme-treated asparagus extract (ETAS) has been developed as a functional material produced from asparagus stem. Studies were conducted to determine the effect of ETAS on heat shock protein 70 (HSP70) expression and alleviation of stress. HeLa cells were treated with ETAS, and HSP70 mRNA and protein levels were measured using a reverse transcription-polymerase chain reaction (RT-PCR) assay and an enzyme-linked immunosorbent assay (ELISA), respectively. ETAS showed significant increases in HSP70 mRNA at more than 0.125 mg/mL and the protein at more than 1.0 mg/mL. The antistress effect was evaluated in a murine sleep-deprivation model. A sleep-deprivation stress load resulted in elevation of blood corticosterone and lipid peroxide concentrations, while supplementation with ETAS at 200 and 1000 mg/kg body weight was associated with significantly reduced levels of both stress markers, which were in the normal range. The HSP70 protein expression level in mice subjected to sleep-deprivation stress and supplemented with ETAS was significantly enhanced in stomach, liver, and kidney, compared to ETAS-untreated mice. A preliminary and small-sized human study was conducted among healthy volunteers consuming up to 150 mg/d of ETAS daily for 7 d. The mRNA expression of HSP70 in peripheral leukocytes was significantly elevated at intakes of 100 or 150 mg/d, compared to their baseline levels. Since HSP70 is known to be a stress-related protein and its induction leads to cytoprotection, the present results suggest that ETAS might exert antistress effects under stressful conditions, resulting from enhancement of HSP70 expression.

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Section: Resultsmentioning

confidence: 99%

Enzyme‐Treated Asparagus Extract Promotes Expression of Heat Shock Protein and Exerts Antistress Effects

Ito

Maeda

Goto

et al. 2014

Journal of Food Science

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“…Asparagus butanol [196][197][198] extract significantly decreased the levels of body weight gain, serum total cholesterol and low density lipoprotein cholesterol; it dramatically increased the high density lipoprotein level when administered at three different doses (40, 80 or 160 mg/kg body weight) for 8 weeks in hyperlipidemic mice. In addition, asparagus butanol extract decreased the levels of alanine transaminase, aspartate transaminase and alkaline phosphatase in serum.…”

Section: Asparagus Officinalismentioning

confidence: 93%

Medicinal plants for prevention and treatment of cardiovascular diseases - A review

Al-Snafi¹

2017

IOSRPHR

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There were substantial evidences that many medicinal plants decreased the risk of cardiovascular diseases. With the high prevalence of herbal medicine use worldwide, the information regarding the therapeutic use or safety of herbal remedies usually obtained from books and pamphlets, most of which base their information on traditional reputation rather than relying on existing scientific research. This review will cover the plants with vascular, hypotensive, cardiac, cardioprotective, antiarrhythmic, hypolipidemic, hemostatic, fibrinolytic and anticoagulant effects.Keywords: medicinal plants, cardioprotective, antiarrhythmic, hypolipidemic, hemostatic, fibrinolytic, anticoagulant I . INTRODUCTION:There were substantial evidences that many medicinal plants decreased the risk of cardiovascular diseases. Previous reviews revealed that many medicinal plants affected cardiovascular function and can be utilize for therapeutic purposes. They produced wide range of cardiovascular effects included vascular, hypotensive, positive and negative inotropic, cardioprotective, antiarrhythmic, hypolipidemic, hemostatic, fibrinolytic and anticoagulant effects [1][2]. This review was designed to cover the cardiovascular effects of medicinal plants. Plants with vascular and hypotensive effects:Plant The tested constituent Activity Ref Adonis vernalis tincture of Adonis vernalisTincture of Adonis vernalis was evaluated as hypotensive therapy. The dog blood pressure responses was varied with dose, low doses showed rise in blood pressure whereas larger doses showed fall in blood pressure. 4Agrimonia eupatoria different extracts A hypotensive effect in anaesthetised cats has been documented for an agrimony extracts given by intravenous injection; blood pressure was lowered by more than 40%. 5-6Allium sativum raw and extracts Experimental and clinical studies showed that garlic produced hypotensive effects. Garlic induced significant reduction in systolic and diastolic blood pressure. 7-12Althaea rosea alcoholic extract The alcoholic extract showed a transient hypotensive effect on anesthetic cats. 13 Ammi visnaga visnadine and visnaginVisnadine caused nonspecific inhibition of vascular smooth muscle. It was selectively inhibited the contractile response in the rat isolated aortic ring and portal vein segment. On the other hand ,intravenous administration of visnagin decreased blood pressure with no significant changes on the heart rate.14-16 chloroform, and methanol extract A chloroform, and methanol extract (1mg/ml) of the fruits inhibited the potassium chloride induced contractions of the rabbit guinea-pig aorta in vitro. 17-18 visnadinVisnadin, 60.0 μg/ml or 120.0 μg/ml, increased coronary blood flow in isolated guinea-pig hearts by 46% and 57% respectively. 19-20visnadin Visnagin inhibited the contractile responses induced in rat aortic rings by: (a) KCl or increases of extracellullar Ca 2+ in KCl depolarized aortic rings, its effects being more potent against low (20 mM) than high (80 mM) KCl-induced contractions, (b...

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“…Fuentes-Alventosa et al (2009) reported that high dietary fiber powder obtained from asparagus by-product exhibited antioxidant activity. The results from our laboratory showed that aqueous, ethanolic and n-butanol extracts from residue of asparagus woody stems (juice removed) displayed hypolipidemic property in hyperlipidemic mice (Zhu et al 2010(Zhu et al , 2011, and the aqueous extract was also found to exhibit hypoglycemic activity in diabetic rats (Zhao et al 2011a).…”

Section: Introductionmentioning

confidence: 99%

“…The results from our laboratory showed that aqueous, ethanolic and n‐butanol extracts from residue of asparagus woody stems (juice removed) displayed hypolipidemic property in hyperlipidemic mice (Zhu et al . , ), and the aqueous extract was also found to exhibit hypoglycemic activity in diabetic rats (Zhao et al . ).…”

Section: Introductionmentioning

confidence: 99%

The Juice of Asparagus By-Product Exerts Hypoglycemic Activity in Streptozotocin-Induced Diabetic Rats

Wen

Wang

et al. 2014

Journal of Food Biochemistry

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The woody ends of asparagus (Asparagus officinalis L.) spears contain various bioactive substances. However, they are often discarded as by‐products. We extracted juice from recycled woody stems of asparagus (AJ) to investigate its hypoglycemic effect in a streptozotocin‐induced diabetic rat model. The diabetic rats showed significant decreased fasting serum glucose, glycosylated serum protein and malondialdehyde levels after 21 days of AJ treatment. Moreover, the oral glucose tolerance test revealed that AJ treatment can significantly reduce rat blood glucose level at 30, 60 and 120 min after glucose loading. These results demonstrated the hypoglycemic activity of AJ and its potential therapeutic use in preventing diabetic complications associated with hyperglycemia and oxidative stress. Practical Applications Asparagus, a healthy and nutritious vegetable, is commonly consumed in many regions of the world. In addition to its edible value, this plant has been reported to possess various biological activities. During harvest, the woody ends of asparagus, around 30–40% of each spear, are usually discarded as by‐product. In fact, this by‐product has been reported to be rich in many bioactive phytochemicals. In the current study, we identified that juice from woody stems of asparagus (AJ) exerted potential hypoglycemic activity in streptozotocin‐induced diabetic rats. We found that oral administration of AJ significantly decreased the elevated levels of fasting serum glucose, glycosylated serum protein and serum malondialdehyde in diabetic rats. Moreover, we found AJ could improve the impaired glucose tolerance in diabetic rats. Overall, our findings suggest that AJ might have potential usage in food supplements for its therapeutic effects.

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Hypolipidemic Effect of n‐Butanol Extract from Asparagus officinalis L. in Mice fed a High‐fat Diet

Cited by 24 publications

References 22 publications

Enzyme‐Treated Asparagus Extract Promotes Expression of Heat Shock Protein and Exerts Antistress Effects

Enzyme‐Treated Asparagus Extract Promotes Expression of Heat Shock Protein and Exerts Antistress Effects

Medicinal plants for prevention and treatment of cardiovascular diseases - A review

The Juice of Asparagus By-Product Exerts Hypoglycemic Activity in Streptozotocin-Induced Diabetic Rats

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