Hypolipidemic effect of Irvingia gabonensis fruits juice on sodium fluoride induced dyslipidemia in rats

Emejulu, A. A.; Alisi, C. S.; Asiwe, E. S.; Iheanacho, K. M. E.; Onwuliri, V. A.

doi:10.5897/ajbr2014.0782

Cited by 10 publications

(7 citation statements)

References 20 publications

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“…Furthermore, polyphenolic compounds, flavonoids inclusive identified in our study, are known antioxidants that prevent the oxidative stress resulting from inflammatory processes [27][28][29][30]. They are also beneficial antimicrobial, antiulcer, antiviral agents [31], in addition, their tumor suppressing and hepatoprotective effect have been reported [1,32]. The scavenging activity of flavonoids have been reported to be in the order: myricetin > quercetin > rhamnetin > morin > diosmetin > naringenin > apigenin > catechin > 5,7-dihydroxy-3',4',5'trimethoxyflavone > robinin > kaempferol > flavone [33].…”

Section: Acute Toxicity Studies On P Americana Seed Ethyl Acetate Fractionmentioning

confidence: 68%

“…Plants have been identified as important source of phyto-active compounds with verifiable medicinal properties and nutraceutical benefits [1,2] Medicinal plants are applied in herbal-based medication for therapeutic, healing or alleviation of diseases in humans [3]. It is estimated that 80% of Asians and Africans living in rural communities depend on herbal medicine for their primary healthcare [4].…”

Section: Introductionmentioning

confidence: 99%

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Bioactive Composition and Acute Oral Toxicity Studies on Persea Americana Seed Ethyl Acetate Fraction

Asiwe

Igwe

Iheanacho

et al. 2021

AJRB

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Aims: Persea americana (P. americana) dubbed ‘green gold’ is a highly sought after fruit today, with insatiable export market. Different parts of avocadoes have been consumed both for nutritional and health benefits across regions of the world. Therefore, this study investigates the bioactive composition of P. americana seed ethyl acetate fraction and acute toxicological effects. Place and duration of study: Department of Biochemistry, Federal University of Technology Owerri, Imo State, Nigeria; between May 2019 and October, 2019. Methodology: Quantitative phytochemical composition was assessed using gas chromatography fitted with flame ionization detector (GC-FID) and acute toxicity determined using standard method. Results: Result of quantitative phytochemical composition of P. americana seed fraction shows a rich presence of phytochemicals such as epicatechin, kaempferol, proanthocyanin, rutin, resveratrol, ribalinidine, naringin, spartein, quinine, flavan-3-ol, anthocyanin, lunamarin, sapogenin, flavonones, flavones. The quantitative phytochemical composition of P. americana seed shows that among other phytochemicals, the seed is relatively rich in anthocyanin, quinine, epicatechin, tannin and proanthocyanin with concentrations of 69.39 ± 8.33 µg/g, 22.16 ±1.77 µg/g, 21.88 ± 2.53 µg/g, 19.86 ± 1.19 µg/g and 10.98 ± 0.55 µg/g respectively. The acute toxicity studies on the seed reveal that the ethyl acetate fraction of P. americana seed did not elicit any lethal signs of morbidity and mortality at doses up to 5000mg/Kgb.wt. and are therefore considered generally safe. Conclusion: P. americana seed ethyl acetate fraction contains essential phytochemicals with useful phyto-medicinal and nutraceutical benefits. The implications of these findings are further discussed.

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Section: Acute Toxicity Studies On P Americana Seed Ethyl Acetate Fractionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Bioactive Composition and Acute Oral Toxicity Studies on Persea Americana Seed Ethyl Acetate Fraction

Asiwe

Igwe

Iheanacho

et al. 2021

AJRB

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“…Use of some of this wild fruits can do much to combat malnutrition and sustain life. It has been established that I. gabonensis contains elemental micronutrients and we had observed a hypolipidemic effect of the fruit juice on sodium fluoride induced dyslipidemia in rats [12].…”

Section: Introductionmentioning

confidence: 72%

“…Hence the increase in total cholesterol observed in our study is believed to be as a result of increased HDL-cholesterol synthesis. Lipid profile studies were not carried out in this study to ascertain the exact cholesterol lipoprotein that was increased, but we had earlier observed a hypolipidemic effect of the fruit juice on sodium fluoride induced dyslipidemia in rats, as a result of increased HDL-C synthesis [12].…”

Section: Results Shown Onmentioning

confidence: 99%

Renal and Hepato-Protective Effects of Irvingia gabonensis Juice on Sodium Fluoride-Induced Toxicity in Wistar Rats

Emejulu¹,

Alisi²,

Asiwe³

et al. 2016

J Clin Toxicol

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Objective: Renal and hepato-protective effects of Irvingia gabonensis juice on sodium fluoride-induced toxicity was assessed in twenty-four male Wistar albino rats. Methodology:The rats were divided into 4 groups of 6 animals each. All except normal control (NC), were intoxicated with 20 mg.Kg -1 body weight of sodium fluoride (NaF) daily by gavage for 35 days. Sodium fluoride control group (NaFC) received only the toxicant. Test group (IG) received I. gabonensis juice concurrently with the toxicant, while the standard control (Q+Vit. E) received concurrently, 15 mg.Kg -1 body weight of Quercetin+100 mg.Kg -1 body weight of α-tocopherol throughout the 35 days. Normal control (NC) group received only standard pelletized diet and water. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein, albumin, total cholesterol, serum creatinine and electrolyte levels were assessed among test, standard and control animals.Result: Irvingia gabonensis significantly (p<0.05) reduced AST activity in the IG group (137.68 ± 12.66 U/L) compared to NaFC group (175.12 ± 10.63 U/L). This compares to the reduction in the AST activity in standard (Q +Vit. E) group (135.69 ± 10.66 U/L). ALT activity was also reduced in the IG group. Effects of I. gabonensis on albumin and cholesterol levels were similar to that of the standard group. Administration of I. gabonensis also significantly (p<0.002) reduced elevated creatinine and Clconcentrations, while significantly (p<0.05) elevating serum Ca 2+ and Mg 2+ ion levels.Conclusion: Irvingia gabonensis fruit juice has some renal and hepato-protective potential which may be due to the presence of secondary plant metabolites like flavonoids, tannins and alkaloids found in the plant. The fruit is also rich in Ca 2+ and Mg 2+ . Increased domestication is encouraged.

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“…Hence, the search for an ideal anti-ulcer drug continues and has also been extended to medicinal plants/herbs in search of new and novel molecules, which may afford better protection and decrease the incidence of relapse. Plants have been identified as an important source of phytoactive compounds with verifiable medicinal properties and protective potential against toxicity" [15].…”

Section: Introductionmentioning

confidence: 99%

Ulcero-Protective Potential of Ethyl Acetate Fractions of Persea americana Seed and Bryophyllum pinnatum Leaf Binary Combinations in Indomethacin Induced Gastric Ulcer

Asiwe

Igwe

Iheanacho

et al. 2022

AJBGMB

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Aims: This study was aimed at investigating the protective potential of ethyl acetate fractions of Persea americana (PA) seed and Bryophyllum pinnatum (BP) leaf binary combinations against indomethacin-induced gastric ulcers. Methodology: Fifty (50) male Wistar rats were used in this study; they were assigned into 10 groups of five animals each and respective groups received a standard rat diet and drinking water ad libitum. The groups were group 1 (normal control group (NC)), group 2 (ulcer control (UC)), group 3 (Omeprazole, 20mgkg-1 (OMEP)), group 4 (PA) and group 5 (BP). Groups receiving binary combinations were group 6 (PA + BP, 1:1), group 7 (PA + BP, 1:2), group 8 (PA + BP, 1:3), group 9 (PA + BP, 2:1), group 10 (PA + BP, 3:1) each group was pre-treated with 400 mgKg-1 body weight/day of respective fraction or binary mixture by intubation for 21 days. On the 22nd day after overnight fasting, a gastric ulcer was induced with indomethacin (30mg/kg body weight) by intubation in a single dose. Ulcer markers and histopathology of stomach tissues were measured using standard methods. Results: The present study revealed that the ethyl acetate fraction of the plants PA seeds and BP leaf showed potent gastric tissue protective effects. Analysis of gastric changes indicated a significant (P<0.05) reduction in ulcer index, gastric acid output, gastric mucus content and pepsin activity of ulcerated rats pretreated with PA and BP fractions. The effect of the binary combinations was significantly (p<0.05) higher than single plant fractions. The protective effect of the fractions was in the order OMEP > PA+BP (3:1) > PA+BP (2:1) > PA+BP (1:1), > PA+BP (1:2) > PA+BP (1:3) > PA > BP. The observed ulcero-protective effect of the binary combinations of P. americana seed and B. pinnatum leaf may be attributed to the synergy of the phytochemicals contained in the fractions. Conclusion: These findings suggest that P. americana and B. pinnatum ethyl acetate fraction combination favorably protect against indomethacin-induced gastric mucosal oxidative damage, reducing ulcer index, gastric acid output, gastric mucus content and pepsin activity. The ethyl acetate fractions exhibited a dose-dependent inhibition of ulcer formation in indomethacin gastric ulcer model.

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Hypolipidemic effect of Irvingia gabonensis fruits juice on sodium fluoride induced dyslipidemia in rats

Cited by 10 publications

References 20 publications

Bioactive Composition and Acute Oral Toxicity Studies on Persea Americana Seed Ethyl Acetate Fraction

Bioactive Composition and Acute Oral Toxicity Studies on Persea Americana Seed Ethyl Acetate Fraction

Renal and Hepato-Protective Effects of Irvingia gabonensis Juice on Sodium Fluoride-Induced Toxicity in Wistar Rats

Ulcero-Protective Potential of Ethyl Acetate Fractions of Persea americana Seed and Bryophyllum pinnatum Leaf Binary Combinations in Indomethacin Induced Gastric Ulcer

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