Hypolipidemic effects of <i>Rosmarinus officinalis</i> L

Farkhondeh, Tahereh; Samarghandian, Saeed; Pourbagher‐Shahri, Ali Mohammad

doi:10.1002/jcp.28221

Cited by 17 publications

(15 citation statements)

References 65 publications

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“…Some documented pharmacological applications of medicinal plants include antioxidant [4], anti-inflammatory [5], hypolipidemic [6], antidiarrheal [7], anti-proliferative [8,9], antihypertensive [10], neuroprotective [11], hepatoprotective [12], nephroprotective [13,14], antidiabetic [15], anti-ulcer [16,17], gastroprotective [18,19], haematopoietic [20] and many more.…”

Section: Introductionmentioning

confidence: 99%

Sub-acute toxicity of Caladium bicolor (Aiton) leaf extract in Wistar rats

Omotoso¹,

Brown²,

Okojie³

2020

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Herbal medicinal plants constitute an integral component of plant biodiversity whose application for therapeutic purposes has been a common practice since antiquity. However, studies have reported tissue pathologies following exposure to herbal medicinal plants or extracts. This study was carried out to assess the possible pathological effects of sub-acute exposure of methanol extract of Caladium bicolor on the hepatic histomorphology of experimental Wistar rats. Twenty four Wistar rats were divided into four groups A-D. Group A was administered with distilled water (2 ml/kg b.w) and groups B-D administered with 100 ml/kg, 200ml/kg and 300ml/kg b.w. of the extract respectively for twenty eight days. The bodyweight of experimental animals was recorded at regular intervals during the study period. After the treatment period, hepatic tissue was harvested, weighed and processed for histopathological study. The results showed that exposure to the extract causes significant (p<0.05) body and organ weight reduction, a significant increase in serum level of ALT and AST as well as prominent hepatic histopathological changes such as inflammation, necrosis and steatosis. Sub-acute exposure to methanol extract of C. bicolor thereby causes dose-independent hepatopathy in experimental animals. Hence, its application for therapeutic purposes needs to be re-evaluated and preferably discontinued to avoid these associated hepatic tissue pathologies.

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Section: Introductionmentioning

confidence: 99%

Sub-acute toxicity of Caladium bicolor (Aiton) leaf extract in Wistar rats

Omotoso¹,

Brown²,

Okojie³

2020

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“…These changes are maybe due to the hypolipidaemic and hypocholesterolaemic effects of rosemary extract (Afonso et al, 2013;Al Sheyab et al, 2012;Farkhondeh et al, 2019). The lack of adverse effects of diets containing rosemary extracts on most other serum biochemical parameters can also indicate that the fish were in good nutritional and health condition and had no signs of organ failure.…”

Section: Innate Immunity and Biochemical Parametersmentioning

confidence: 99%

Use of dietary rosemary ( Rosmarinus officinalis L.) extract as a growth promotor and immunostimulant in common carp

Dezfoulnejad

Molayemraftar

2021

Aquaculture Research

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This study aimed to investigate the effects of rosemary leaf extract (Rosmarinus officinalis L.) on growth, haematological parameters, immunological profile and body composition in common carp (20.35 ± 0.37 g). The fish (n = 240) were fed with 0.0%, 0.25%, 0.5% and 1% of rosemary extract in 12 aquaria (300 L) with three replicates (each with 30 fish) for 60 days. At the end of the trial, final weight, WG, SGR, FCR and CF levels were significantly higher in a dose-dependent manner in the groups fed the diet containing rosemary extract compared with the control group. Moreover, the results of measured trial indices showed a significant increase in a dose-dependent manner in WBC and RBC counts, haemoglobin, haematocrit, lysozyme, complement, respiratory burst, total protein, albumin and glucose in the fish fed the diet containing rosemary extracts compared with the control group. The contents of cholesterol, triglyceride and LDL were significantly decreased in a dose-dependent manner and HDL level significantly increased in the groups fed diets containing rosemary extract.The findings of this research suggest that adding rosemary extract, especially 1%, to the food regime could positively change the growth parameters, haematological and immunological profiles of Cyprinus carpio.

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“…Rosmarinus officinalis L. Esta espécie é conhecida popularmente como alecrim, alecrim de cheiro e rosmarinho, pertencente à família Lamiaceae, e apresenta como sinônimo Salvia rosmarinus Schleid., sendo oriundo da região do Mediterrâneo e atualmente é cultivada em diferentes países do mundo (Allegra, Tonacci, Pioggia, Musolino, & Gangemi, 2020;Lee, Garcia, Martinazzo & Teodoro, 2020). O R. officinalis apresenta propriedades terapêuticas como antioxidante, anti-inflamatória, cicatrizante, alopecia, antifúngica, antidepressiva, antibacteriana, antirreumática e antiespasmódico (Farkhondeh, Samarghandian, & Pourbagher-Shahri, 2019;Goes et al, 2020;Macedo et al, 2020). O óleo essencial (OE) desta planta aromática é obtido por meio das folhas e flores através da hidrodestilação, apresentando aspecto incolor ou levemente amarelo-esverdeado (Anvisa, 2019).…”

Section: Existem Diversos Oes Utilizados Atualmente Na Aromaterapia Cunclassified

Aromaterapia de Rosmarinus officinalis L. (Lamiaceae) em testes in vivo: revisão sistemática

Santos

Ferrante

Gavilanes

et al. 2020

RSD

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Aromaterapia, é uma técnica terapêutica complementar antiga que utiliza óleo essencial de plantas aromáticas a fim de proporcionar bem estar físico e mental. Existem diferentes óleos utilizados nesta prática como por exemplo de Rosmarinus officinalis (alecrim) que apresenta atividade estimulante e ansiolítico. Este estudo teve como objetivo identificar os principais trabalhos científicos realizados in vivo com o óleo essencial do alecrim e verificar o potencial terapêutico complementar desta planta medicinal. A revisão sistemática realizada utilizou dados disponíveis no periódicos CAPES (Scopus, Web of Science, Pubmed e Scielo), tendo como palavra-chave “Aromatherapy”. Foram incluídos documentos a partir de 2010, escritos em inglês, francês, espanhol e português que realizavam testes in vivo com óleo essencial de alecrim ou misturas contendo esta planta. A partir desta busca foram selecionados apenas treze artigos científicos publicados na Turquia, Hungria, Estados Unidos, Tailândia, Irã, Japão e Alemanha; onde a maioria dos testes foram realizados na espécie humana (84,62%). O método mais utilizado nos experimentos foi a inalação dos óleos essenciais (61,54%), sendo empregado 30,77% o óleo de alecrim puro e 69,23% misturas contendo esta espécie. Conclui-se que o óleo essencial puro de alecrim através do método de inalação apresentou efeito estimulante e antiestresse em humanos e melhora na função cognitiva na demência do tipo Alzheimer em ratos.

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Hypolipidemic effects of Rosmarinus officinalis L

Cited by 17 publications

References 65 publications

Sub-acute toxicity of Caladium bicolor (Aiton) leaf extract in Wistar rats

Sub-acute toxicity of Caladium bicolor (Aiton) leaf extract in Wistar rats

Use of dietary rosemary ( Rosmarinus officinalis L.) extract as a growth promotor and immunostimulant in common carp

Aromaterapia de Rosmarinus officinalis L. (Lamiaceae) em testes in vivo: revisão sistemática

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