Hypolipidemic effects ofSolidago chilensishydroalcoholic extract and its major isolated constituent quercetrin in cholesterol-fed rats

Abstract

(2015) Hypolipidemic effects of Solidagochilensis hydroalcoholic extract and its major isolated constituent quercetrin in cholesterol-fed rats, Pharmaceutical Biology, 53:10, 1488-1495, DOI: 10.3109/13880209.2014 Objective: This study evaluates the hypolipidemic and antioxidant effects of hydroalcoholic extract (HE) and quercetrin from S. chilensis aerial parts in cholesterol-fed rats. Materials and methods: The HE was analyzed by high-performance liquid chromatography, followed by quercetrin isolation. Hypercholesterolemic rats (1% cholesterol and 0.5% cholic acid for 15 d) were treated with HE (150, 300, and 600 mg/kg p.o.; n ¼ 6), simvastatin (4 mg/kg p.o.; n ¼ 6), or quercetrin (10 mg/kg p.o.; n ¼ 6) once a day for 30 d. During this period, a highcholesterol diet was maintained until the 30th day of treatment.Results: Rats treated with HE (150, 300, and 600 mg/kg) and quercetrin showed decreased serum levels of total cholesterol (À19.9, À27.5, À31.0, and À39.4%), lipoprotein-cholesterol (À36.0, À37.5, À43.3, and À59.4%), and triacylglycerides (À15.6, À23.5, À29.8, and À27.2%) when compared with the control group similar to simvastatin. Moreover, treatment with HE and quercetrin decreased hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity (35.1% on average) and increased fecal cholesterol levels (38.2% on average). Discussion and conclusions: Our results suggest that hypolipidemic effects of HE are associated with it modulating the activity of HMG-CoA reductase and its interference in the reabsorption and/or excretion of intestinal lipids. Solidago chilensis and its main constituent, quercetrin, may thus be effective as cholesterol-lowering agents and in preventing atherosclerosis.

Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats

“…We cannot discount the possibility that HE also interferes with cholesterol's metabolic cycle at other points, such as intestinal uptake, endogenous metabolism, and transport by lipoproteins (Bei et al, 2012;Roman-Junior et al, 2015), which were not assessed in this study.…”

Quercitrin Ameliorates Hyperlipidemia and Hepatic Steatosis in Ovariectomized Mice

“…Quercetin is the most common flavonoid in nature, and it is mainly present in glycosylated forms such as Quer [ 12 ]. Quer has several biological activities, such as anti-inflammatory, antioxidant, and hypolipidemic effects [ 12 , 13 , 14 ]. In order to explain the dosage used at the beginning, daily flavonoid intake (typically present in onion, apple, grape, wine, herbs and spices) in human diet is highly variable, with estimations ranging from 23 mg/day [ 32 ] to more than 500 mg/day [ 33 ].…”

“…Quercitrin (3,5,7,3 ,Quer), a glycosylated form of quercetin, is a naturally available type of flavonoid used in dietary supplements and as a dietary ingredient. Quer has several pharmacological activities, including antimicrobial, anti-inflammatory, and hypolipidemic effects [12][13][14]. However, numerous studies have focused on the aglycone (quercetin) form, and limited information is available regarding the biological effects of glycoside forms, such as the potential of flavonoids in the treatment of NAFLD [15].…”

Hypocholesterolemic efficacy of royal jelly in healthy mild hypercholesterolemic adults

“…Cholesterol is an essential substance with several physiological functions; however when its level elevates substantially in the blood (hypercholesterolemia) that leads to various deleterious conditions such as atherosclerosis and related cardiovascular diseases (CVD) (Roman et al. 2015 ). Hypercholesterolemia is considered as a major culprit for CVD, which contributes about one-third of total deaths globally (Katz et al.…”