Hypolipidemic effects of macadamia oil are related to AMPK activation and oxidative stress relief: In vitro and in vivo studies

Shuai, Xixiang; Dai, Taotao; McClements, David Julian; Ruan, Roger; Du, Liqing; Liu, Yuhuan

doi:10.1016/j.foodres.2023.112772

Cited by 14 publications

(5 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An increasing number of studies have shown that lipid metabolic processes are associated with the activation of the AMPK signaling pathway. 63,64 Combining the above information and based on the ameliorative effect of Ace Pg3G on lipid deposition and promotion of autophagy process, we hypothesized that this positive effect might be related to the activation of AMPK signaling pathway. It was reported that maintaining AMPK phosphorylation could lead to increased AMP/ATP and ADP/ATP ratios, thus activating AMPK pathway.…”

Section: Resultsmentioning

confidence: 99%

Acetylated pelargonidin-3-O-glucoside alleviates hepatocyte lipid deposition through activating the AMPK-mediated lysosome-autophagy pathway and redox state

Xie,

Hao,

Xie

et al. 2024

Food Funct.

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Acetylated pelargonidin-3-O-glucoside alleviates hepatocyte lipid deposition through activating the AMPK-mediated lysosome-autophagy pathway and redox state

Xie,

Hao,

Xie

et al. 2024

Food Funct.

View full text Add to dashboard Cite

show abstract

“…Therefore, de novo lipogenesis has been increasingly viewed as a target for the treatment of metabolic diseases (Ameer et al, 2014). Macadamia oil has been shown to activate AMPK and inhibit de novo lipogenesis both in vitro and in vivo, thereby improving lipid metabolism and alleviating oxidative stress (Shuai et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

Baicalein, a dietary flavonoid, enhances the insulin‐sensitizing effect of metformin to prevent type 2 diabetes via the regulation of lipid metabolism and gut microenvironment

Xing,

Liu,

Zhang

et al. 2024

Food Frontiers

View full text Add to dashboard Cite

Baicalein is a natural flavonoid abundant in various foods and dietary plants, including Tuber aestivum and Oroxylum indicum. In this study, we investigated the role of baicalein in enhancing the insulin‐sensitizing effect of metformin in mice with prediabetes. Baicalein, when combined with 25% of normal‐dose metformin, achieved a diabetes‐reversion rate of 80%, which was 1.86‐fold that of normal‐dose metformin. Mechanistically, baicalein enhanced the insulin‐sensitizing effect of metformin on lipid metabolism by inhibiting de novo lipogenesis through the AMP‐activated protein kinase/SREBP‐1c/FASN pathway and by inducing fatty‐acid β‐oxidation through the upregulation of ACSL1, CPT1A, EHHADH, and acyl‐CoA dehydrogenases (ACADL/ACADM/ACADS). Meanwhile, baicalein enhanced the insulin‐sensitizing effect of metformin via the modulation of the gut microenvironment by enriching probiotics, especially Akkermansia by 53.4‐fold, depleting opportunistic pathogens, and strengthening the intestinal barrier. The improved gut microenvironment led to the alleviation of chronic endotoxemia, as evidenced by decreased levels of lipopolysaccharide and proinflammatory cytokines. Furthermore, baicalein enhanced the effect of metformin on decreasing the circulating level of branched‐chain amino acids (BCAAs), which further improved insulin sensitivity by normalizing the mTORC1/p70S6K/IRS1 signaling pathway and de novo lipogenesis. Moreover, the role of baicalein in enhancing the insulin‐sensitizing effect of metformin was verified by an oleic acid‐induced steatosis model and a BCAA‐induced insulin resistance model in hepatocytes. Our study laid a theoretical foundation for developing baicalein into a dietary supplement for diabetes prevention. The diverse mechanisms of food‐derived flavonoids can be applied in the development of dietary supplements to enhance the efficacy of oral hyperglycemic agents currently used in clinics.

show abstract

“…Hirako et al 38) found that fish oil can prevent excessive lipid accumulation in the liver while also preventing oxidative stress. Shuai and Dai 39) found that macadamia oil can lower blood lipids and alleviate oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Lipid Composition between Quasipaa spinosa Oil and Rana catesbeiana Oil and Its Effect on Lipid Accumulation in Caenorhabditis elegans

He,

Wu,

Liu

et al. 2024

J. Oleo Sci.

View full text Add to dashboard Cite

Frog oil has been recognized for its nutritional and medicinal value. However, there is limited research on the role of frog oil in preventing obesity. In this study, we aimed to investigate the lipid composition of Quasipaa spinosa oil (QSO) and Rana catesbeiana oil (RCO) using lipidomics analysis. We compared the lipid accumulation effects of these two kinds of frog oils and soybean oil (SO) in Caenorhabditis elegans (C. elegans). Additionally, we determined the gene expression related to lipid metabolism and used the nhr-49 mutant (RB1716) and sir-2.1 mutant (VC199) for validation experiments. The results showed that the lipid composition of QSO and RCO was significantly different (p < 0.05), and QSO was rich in more polyunsaturated fatty acids (PUFAs). After feeding C. elegans, the lipid accumulation of the QSO group was the lowest among the three dietary oil groups. In addition, compared with RCO and SO, QSO significantly inhibited the production of malondialdehyde (MDA) and increased the activity of superoxide dismutase (SOD). The effects of three kinds of dietary oils on the fatty acid composition of C. elegans were significantly different. Compared with SO and RCO, QSO significantly up-regulated (p < 0.05) the expression of sir-2.1 and ech-1 genes. The results showed that QSO might reduce lipid accumulation through the SIRT1 and nuclear hormone signaling pathways. Such a situation was verified experimentally by the nhr-49 mutant (RB1716) and sir-2.1 mutant (VC199). This study proposed a new functional oil, laying the groundwork for developing functional foods from Quasipaa spinosa.

show abstract

Hypolipidemic effects of macadamia oil are related to AMPK activation and oxidative stress relief: In vitro and in vivo studies

Cited by 14 publications

References 42 publications

Acetylated pelargonidin-3-O-glucoside alleviates hepatocyte lipid deposition through activating the AMPK-mediated lysosome-autophagy pathway and redox state

Acetylated pelargonidin-3-O-glucoside alleviates hepatocyte lipid deposition through activating the AMPK-mediated lysosome-autophagy pathway and redox state

Baicalein, a dietary flavonoid, enhances the insulin‐sensitizing effect of metformin to prevent type 2 diabetes via the regulation of lipid metabolism and gut microenvironment

Comparison of Lipid Composition between <i>Quasipaa spinosa</i> Oil and <i>Rana catesbeiana</i> Oil and Its Effect on Lipid Accumulation in <i>Caenorhabditis elegans</i>

Contact Info

Product

Resources

About