Hypomagnesemia Is a Common Complication of Aminoglycoside Therapy

Zalonga, G. P.; Chernow, Bart; Pock, Arnyce; Wood, Blair P.; Zaritsky, Arno; Zucker, Amanda

doi:10.1097/00132586-198502000-00039

Cited by 15 publications

(22 citation statements)

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“…The literature supports hypocalcemia is one of the frequently associated electrolyte abnormalities as magnesium deficiency impairs parathyroid glandular function and may lower serum concentrations of vitamin D, leading to hypocalcemia. [17][18] Like Sheehan et al, 19 Zaloga et al, 20 in the present study it was found that the hypomagnesemic group received diuretics and aminoglycosides more often than normo-magnesemic group. Diuretic use both loop and thiazide diuretics can inhibit net magnesium reabsorption and causing hypomagnesemia.…”

Section: Discussionsupporting

confidence: 66%

On admission hypomagnesemia in critically ill children: Risk factors and outcome

Saleem

Haque

2009

Indian J Pediatr

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Section: Discussionsupporting

confidence: 66%

On admission hypomagnesemia in critically ill children: Risk factors and outcome

Saleem

Haque

2009

Indian J Pediatr

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“…Those results suggest that, in addition to the proximal tubular nephrotoxicity described above, a different mechanism for gentamicininduced hypercalciuria may also play a role. Furthermore, hypomagnesemia due to renal Mg wasting can occur early in gentamicin therapy and may result in hypocalcemia through decreased parathyroid hormone (PTH) secretion and/or decreased PTH action on kidney and bone [10]. Another possible mechanism implicated in gentamicin-induced hypercalciuria and hypocalcemia includes alteration of the activity of the calcium-sensing receptor (CaR).…”

Section: Discussionmentioning

confidence: 99%

“…Parsons et al demonstrated in the rat that the effect of gentamicin on calcium transport in the renal tubules is dose-related [9]. In addition, an association between aminoglycoside therapy and hypomagnesemia due to urinary magnesium losses has been reported, and this effect may influence serum calcium values [10]. However, the cause(s) of hypocalcemia is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Serum calcium values in term and late-preterm neonates receiving gentamicin

et al. 2008

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Since noting an apparent increase in hypocalcemia in neonates receiving gentamicin every 24 h (q 24 h) for > or = 4 days, we have prospectively monitored serum calcium (Ca) values in these patients receiving prolonged gentamicin therapy. This study is a retrospective analysis of those values measured during gentamicin treatment. The study included neonates with gestational age > or = 35 weeks who received > or = 4 days of gentamicin therapy and in whom at least one serum Ca value was measured > or = 47 h after initiation of therapy. Hypocalcemia was defined as a serum Ca level < 8 mg/dl (2 mmol/l). Data were analyzed by Student t-test, chi-square test, and Pearson product moment correlation. There were 1,624 neonates that met the study criteria. Ca was < 8 mg/dl in 241 (15%). Ca < 8 mg/dl was more likely in boys than in girls (16.4% vs 11.8%, P = 0.01) and in neonates < 37 weeks gestational age (GA) than in those > or = 37 weeks GA (23.9% vs 14.1%, P = 0.01). A second Ca value was obtained in 883 neonates (54%); 23.2% of neonates with initial Ca < 8 mg/dl remained hypocalcemic, and 30% of these were receiving oral Ca supplementation. The second Ca value was < 8 mg/dl in eight neonates in whom initial Ca was > or = 8 mg/dl. Hypocalcemia is not uncommon in neonates receiving gentamicin therapy, and it may occur more frequently in boys and late-preterm infants. These data suggest that the monitoring of serum Ca levels should be considered when gentamicin is given > or = 4 days.

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“…The mechanisms postulated for hypocalcemia include irregular parathyroid secretion, end-organ resistance to parathyroid hormone, and resistance to Vitamin D. (28) However, hypomagnesemia can cause hypocalcemia. (29) Chronic respiratory insufficiency combined with hypoxemia has been described as a cause of Mg depletion and hypomagnesemia. (8) However, we did not manage to confirm this association in the present study.…”

Section: Discussionmentioning

confidence: 99%

Freqüência relativa de hipomagnesemia em pacientes com limitação crônica do fluxo aéreo atendidos em ambulatório de referência do norte do Paraná

2006

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Objective: To determine the relative frequency of hypomagnesemia among patients with chronic airflow limitation treated as outpatients at a referral center in the northern part of the state of Paraná between 2000 and 2001, as well as to determine whether hypomagnesemia correlates with hypoxia, with other electrolyte disturbances and with the severity of airflow limitation. Methods: This was a descriptive study of the relative frequency of hypomagnesemia in 72 patients with chronic airflow limitation. All of the patients were submitted to blood tests to determine serum levels of magnesium and other electrolytes, as well as to staging of the underlying disease. Results: The prevalence of hypomagnesemia was 27.8%. The mean age was 65 ± 9.9 years, and there was a predominance of males. The mean forced expiratory volume in one second was 1.31 ± 0.52 L. Most of the patients (68.1%) were found to be in the advanced stages of the disease. Hypomagnesemia was not found to correlate with other electrolyte disturbances, hypoxemia or disease stage. Conclusion:The high frequency of patients in the advanced stages is likely attributable to the fact that the outpatient facility is a referral center for the region. Further studies should be conducted in order to determine the probable causes of this high prevalence of hypomagnesemia.

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Hypomagnesemia Is a Common Complication of Aminoglycoside Therapy

Cited by 15 publications

References 0 publications

On admission hypomagnesemia in critically ill children: Risk factors and outcome

On admission hypomagnesemia in critically ill children: Risk factors and outcome

Serum calcium values in term and late-preterm neonates receiving gentamicin

Freqüência relativa de hipomagnesemia em pacientes com limitação crônica do fluxo aéreo atendidos em ambulatório de referência do norte do Paraná

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