Hypomethylation of the rat aryl sulfotransferase IV gene and amplification of a DNA sequence during multistage 2-acetylaminofluorene hepatocarcinogenesis

Taurine supplementation improves the utilization of sulfur-containing amino acids in rats continually administrated alcohol

“…Research showed that DNA hypomethylation was involved in animal model of hepatic carcinogenesis [5,6]. Alcohol dehydrogenase localized not only in liver but also in kidney.…”

Cellular Proliferation, Cell Death, and Liver Histology in Gambusia affinis After Dietary Exposure to Benzidine and 2-Aminofluorene

“…59 Several investigations with liver have taken place to determine whether focal proliferation of oval cells are the preneoplastic origin of subsequent neoplasms that are consistently observed during exposures to azo-based dyes and 2AAF. 14,21,46,51,[54][55][56]60,61 A large array of antibodies to hepatocytes, oval cells/bile duct, shared-hepatocytes, and neoplastic antigens in F-344 rats were assayed in primary hepatocellular carcinomas induced by exposure to a single dose of N-nitrosodiethylamine followed by 14 days of 2.5-mg 2AAF exposure. 45,46,51,54 These results indicate that the antigenic phenotype expressed in 20% of the primary hepatocellular carcinomas (PHCs) contained both oval cell-and hepatocyteassociated antigens.…”