Hypomyelination, memory impairment, and blood–brain barrier permeability in a model of sleep apnea

Kim, Lenise Jihe; Martinez, Dênis; Fiori, Cíntia Zappe; Baronio, Diego; Filho, Nélson Alexandre Kretzmann; Barros, Helena Maria Tannhauser

doi:10.1016/j.brainres.2014.11.052

Cited by 30 publications

(25 citation statements)

References 40 publications

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“…A few hours after infection, neutrophils and monocytes infiltrate CNS, and neutrophils seem to be crucial in disruption of BBB permeability [64][65][66] The postmortem study documented a massive infiltration of the brain by immune cells, which was associated with neuronal edema and the scattered red degeneration [42] Noteworthy, activated macrophages and microglia have been present in areas of demyelination and play a critical role in myelin destruction [66]. The hypomyelinated axons were found in experimental animals with short-and long-term memory deficit, and the degree of myelin disorders was associated with memory dysfunction and short-and long-term cognitive dysfunction [67,68]. A large amount of damaged myelin following neuroinflammation is potentially immunogenic and activates macrophages again, which initiate a vicious cycle sustaining further inflammation.…”

Section: Covid-19: Potential Factors Contributing To Icu Deliriummentioning

confidence: 99%

COVID-19: ICU delirium management during SARS-CoV-2 pandemic

et al. 2020

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The novel coronavirus, SARS-CoV-2-causing Coronavirus Disease 19 , emerged as a public health threat in December 2019 and was declared a pandemic by the World Health Organization in March 2020. Delirium, a dangerous untoward prognostic development, serves as a barometer of systemic injury in critical illness. The early reports of 25% encephalopathy from China are likely a gross underestimation, which we know occurs whenever delirium is not monitored with a valid tool. Indeed, patients with COVID-19 are at accelerated risk for delirium due to at least seven factors including (1) direct central nervous system (CNS) invasion, (2) induction of CNS inflammatory mediators, (3) secondary effect of other organ system failure, (4) effect of sedative strategies, (5) prolonged mechanical ventilation time, (6) immobilization, and (7) other needed but unfortunate environmental factors including social isolation and quarantine without family. Given early insights into the pathobiology of the virus, as well as the emerging interventions utilized to treat the critically ill patients, delirium prevention and management will prove exceedingly challenging, especially in the intensive care unit (ICU). The main focus during the COVID-19 pandemic lies within organizational issues, i.e., lack of ventilators, shortage of personal protection equipment, resource allocation, prioritization of limited mechanical ventilation options, and end-of-life care. However, the standard of care for ICU patients, including delirium management, must remain the highest quality possible with an eye towards long-term survival and minimization of issues related to post-intensive care syndrome (PICS). This article discusses how ICU professionals (e.g., physicians, nurses, physiotherapists, pharmacologists) can use our knowledge and resources to limit the burden of delirium on patients by reducing modifiable risk factors despite the imposed heavy workload and difficult clinical challenges posed by the pandemic.

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Section: Covid-19: Potential Factors Contributing To Icu Deliriummentioning

confidence: 99%

COVID-19: ICU delirium management during SARS-CoV-2 pandemic

et al. 2020

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“…An extensive body of work using rodent models has demonstrated that chronic exposures to intermittent hypoxia during the rest period, in the absence of significant sleep fragmentation, is accompanied by neurodegenerative changes, increased oxidative stress and inflammation, and impaired spatial learning in the Morris water maze [15][16][17][18][19][20][21][22][23][24], and that genetic or pharmacological manipulations of oxidative stress pathways attenuated intermittent hypoxia-induced deficits [25][26][27]. However, the recovery from such intermittent hypoxia-induced central nervous system structural and functional alterations has not been systematically investigated.…”

Section: Introductionmentioning

confidence: 99%

Temporal trajectories of novel object recognition performance in mice exposed to intermittent hypoxia

et al. 2017

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Intermittent hypoxia is one of the major perturbations of sleep-disordered breathing and has been causally implicated in neurocognitive deficits. However, the reversibility of such deficits is unclear.Male C57BL/6J mice were exposed to either intermittent hypoxia or room air for 3-240 days, and then half were randomly selected and allowed to recover in normoxic conditions for the same duration of the previous exposure. A novel object recognition (NOR) test was performed.NOR performance was stable over time in room air. Intermittent hypoxia induced significant reductions in recognition index that progressed over the first 45 days and stabilised thereafter. Normoxic recovery of recognition index was essentially complete and indistinguishable from room air in mice exposed to shorter intermittent hypoxia times (<90 days). However, significant residual deficits emerged after normoxic recovery following prolonged intermittent hypoxia exposures (p<0.01). In addition, gradual attenuation of the magnitude of recovery in recognition index occurred with increasingly longer intermittent hypoxia exposures (MANOVA p<0.0001).Intermittent hypoxia during the resting period reduces NOR performance in a time-dependent fashion. Reversal of NOR performance deficits is unlikely after prolonged intermittent hypoxia duration. These findings suggest that early recognition of sleep apnoea and effective treatment are critical for restoration of the adverse cognitive effects of the disease.

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“…Sleep apnea defined as the disruption of breathing for more than 10 s in adults [2]. Daytime sleepiness, impaired concentration, depression, memory loss, tiredness and early morning headaches can be observed in SAS patients [3][4][5][6]. Besides, untreated and undiagnosed sleep apnea can relate to heart disease like hypertension, myocardial infarction and stroke [7][8][9].Sleep disorders have become important factors that adversely affect individuals' quality of life and society as a whole [10].…”

Section: Introductionmentioning

confidence: 99%

Sleep apnea classification based on respiration signals by using ensemble methods

Avci

Akbaş

2015

BME

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Abstract. In this study, an efficient and robust method classifying the minute based occurrence of sleep apnea is aimed. Three respiration signals obtained from abdominal, chest and nasal way extracted from polysomnography recordings. Wavelet transform based on feature extraction methods are applied on the 1 minute length respiration signals. Dimension reduction process is facilitated by using principal component analysis. The features obtained from 8 recordings are used for the classification sleep apnea by using three ensemble classifiers. According to the results, the classification accuracies have been obtained between 92.07-98.43%, 92.75-98.68% and 92.42-98.61% by using three different ensemble classifier based on abdominal, chest and nasal based analysis, respectively for AdaBoost, Random Forest and Random Subspace. However the best result is obtained analyzing nasal based respiratory signal by using Random Forest method. In this case accuracy is 98.68%.

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Hypomyelination, memory impairment, and blood–brain barrier permeability in a model of sleep apnea

Cited by 30 publications

References 40 publications

COVID-19: ICU delirium management during SARS-CoV-2 pandemic

COVID-19: ICU delirium management during SARS-CoV-2 pandemic

Temporal trajectories of novel object recognition performance in mice exposed to intermittent hypoxia

Sleep apnea classification based on respiration signals by using ensemble methods

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