Hyponatraemia in imported malaria: the pathophysiological role of vasopressin

Hoorn, Ewout J.; Wolfswinkel, Marlies E van; Hesselink, Dennis A.; Rijke, Yolanda B. de; Koelewijn, Rob; Hellemond, Jaap J. van; Genderen, Perry J.J. van

doi:10.1186/1475-2875-11-26

Cited by 11 publications

(5 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Normal values of copeptin in healthy volunteers range between 1.70–11.25 pmol/L ( 6 , 9 , 10 ). Copeptin also shows minimal intra-individual variations ( 11 ).…”

Section: Copeptin In Circulationmentioning

confidence: 99%

Copeptin and its potential role in diagnosis and prognosis of various diseases

2013

View full text Add to dashboard Cite

The need for faster diagnosis, more accurate prognostic assessment and treatment decisions in various diseases has lead to the investigations of new biomarkers. The hope is that this new biomarkers will enable early decision making in clinical practice. Arginine vasopressin (AVP) is one of the main hormones of the hypothalamic-pituitary-adrenal axis. Its main stimulus for secretion is hyperosmolarity, but AVP system is also stimulated by exposure of the body to endogenous stress. Reliable measurement of AVP concentration is difficult because it is subject to preanalytical and analytical errors. It is therefore not used in clinical practice. Copeptin, a 39-aminoacid glycopeptide, is a C-terminal part of the precursor pre-provasopressin (pre-proAVP). Activation of AVP system stimulates copeptin secretion into the circulation from the posterior pituitary gland in equimolar amounts with AVP. Therefore, copeptin directly reflects AVP concentration and can be used as surrogate biomarker of AVP secretion. Even mild to moderate stress situations contribute to release of copeptin. These reasons have lead to a handful of research on copeptin in various diseases. This review summarizes the current achievements in the research of copeptin as a diagnostic and prognostic marker and also discusses its association in different disease processes.

show abstract

“…Normal values of copeptin in healthy volunteers range between 1.70–11.25 pmol/L ( 6 , 9 , 10 ). Copeptin also shows minimal intra-individual variations ( 11 ).…”

Section: Copeptin In Circulationmentioning

confidence: 99%

Copeptin and its potential role in diagnosis and prognosis of various diseases

2013

View full text Add to dashboard Cite

show abstract

“…In a study by Ewout J Hoorn, Malaria was an important cause of SIADH. 14,15 Among respiratory causes, pneumonia was the predominant (40.2%) followed by lung carcinoma (4.9%) and pulmonary tuberculosis (2.4%). Two subjects of retroviral illness in this study had hyponatremia (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Clinical and biochemical profile of hyponatremia and the role of vaptans in comparison to other standard modalities of therapy

Ahmed,

Khan,

Umakanth

et al. 2023

Int J Res Med Sci

View full text Add to dashboard Cite

Background: This study, conducted from August 2014 to August 2015, investigated hyponatremia in 228 in-hospital patients, aiming to discern its clinical and biochemical features and compare the efficacy of vaptans against standard treatments. The null hypothesis assumed no significant disparity in outcomes, while the alternate hypothesis posited otherwise. Methods: Using an open-label, non-blinded, observational, prospective comparative design, we assessed 228 hyponatremia patients. We scrutinized their clinical and biochemical profiles and made comparisons between moderate and profound hyponatremia cases, along with different treatment approaches. Results: Our findings revealed that patients aged 61-80, primarily females, dominated the cohort. Moderate hyponatremia occurred in 56.6% of cases, with severe hyponatremia in 43.4%. Common symptoms included drowsiness, nausea, and vomiting. Euvolemic hyponatremia was predominantly due to SIADH, while heart failure led to most hypervolemic cases. Various treatments were employed, with fluid restriction and normal saline being common. Tolvaptan and 1.6% hypertonic saline significantly increased serum sodium levels at 24 and 48 hours. Hospital stay duration didn’t significantly differ, and no osmotic demyelination cases emerged. Mortality stood at 10.5%, notably higher in profound hyponatremia cases. Conclusions: This study provides insights into hyponatremia’s clinical and biochemical aspects and compares vaptans to standard treatments. Tolvaptan and hypertonic saline displayed promise in raising serum sodium levels. Nevertheless, further research is warranted to validate these findings and explore additional factors impacting hyponatremia treatment outcomes.

show abstract

“…Decreased venous return, hypoxemia, and hypercapnia that occasionally accompany lung infections are proposed to induce a non-osmotic ADH release [ [18] , [19] , [20] , [21] , [22] ]. Regulation of serum sodium levels assuming at newer lower target (e.g., 125–135 mmol/L), also known as reset osmostat, was described in malaria and tuberculosis cases [ 23 , 24 ]. Proinflammatory cytokines, namely interleukin-6, can lead to ADH stimulation [ 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%