Hyponatremia and cerebrovascular spasm in aneurysmal subarachnoid hemorrhage

Chandy, Dipak; Sy, Roger; Aronow, Wilbert S.; Lee, Wei-Nchih; Maguire, George P.; Murali, Raj

doi:10.4103/0028-3886.27151

Cited by 45 publications

(34 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The proportion of SAH patients with hyponatremia in this study is similar to data presented by Qureshi et al and Chandy et al (2,3). The presence of a higher WFNS score as a known predictor of disease severity in the hyponatremia group was not a surprise for us.…”

Section: Discussionsupporting

confidence: 79%

“…The predictive value of hyponatremia on clinical outcome and correlations between DCI and hyponatremia was a subject of some studies but the results were inconsistent (2,3,(15)(16)(17). These results did not confirm or negate a possible connection, and our study is an attempt to provide a new contribution in resolving this potentially very interesting matter.…”

Section: Introductionmentioning

confidence: 48%

“…Hyponatremia prevalence rates are approximately 30-55% (1)(2)(3). The etiology of hyponatremia is still unclear but it is probably mediated by hypothalamic injury secondary to SAH.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical and Predictive Significance of Hyponatremia After Aneurysmal Subarachnoid Hemorrhage

Vrsajkov¹,

Javanović²,

Stanisavljević³

et al. 2012

Balkan Med J

View full text Add to dashboard Cite

Objective: Hyponatremia after SAH was the object of several studies with conflicting results. The aim of this study was to determine a predictive correlation of hyponatremia with delayed cerebral ischemia (DCI) and poor clinical outcome. Material and Methods:We have used a retrospective hospital chart review of 82 patients with SAH treated from August 2008 to August 2010. Patients were divided into hyponatremia and normonatremia groups. Hyponatremia was defined as serum sodium level <135 mmol/l. Information compared and analyzed included demographics, preoperative neurological status, aneurysm characteristics, postoperative intensive care, duration of stay, DCI and clinical outcome at hospital discharge. P<0.05 was considered significant.Results: Thirty-two patients with SAH (39%) developed hyponatremia. In that group we had a significantly higher WFNS score at admission (p=0.03) and longer duration of stay in intensive care (p=0.001). DCI with transit or definitive deficit included 20 patients (62%) in the hyponatremia group, and 19 patients (38%) in the normonatremia group (p=0.03). Binary enter logistic regression revealed a significant correlation of hyponatremia with DCI (p=0.03) and poor clinical outcome (p=0.001). Conclusion:This result revealed a possible use of hyponatremia as an additional predictor of developing DCI and poor clinical outcome.

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 48%

See 1 more Smart Citation

Clinical and Predictive Significance of Hyponatremia After Aneurysmal Subarachnoid Hemorrhage

Vrsajkov¹,

Javanović²,

Stanisavljević³

et al. 2012

Balkan Med J

View full text Add to dashboard Cite

show abstract

“…Hyponatremia has been chronologically associated with the onset of sonographic and clinical vasospasm. 295,296 Hyponatremia can develop from different mechanisms after aSAH. The syndrome cerebral salt wasting is produced by excessive secretion of natriuretic peptides and causes hyponatremia from excessive natriuresis, which may also provoke volume contraction.…”

Section: Management Of Medical Complications Associated With Asahmentioning

confidence: 99%

Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage

Connolly¹,

Rabinstein²,

Carhuapoma³

et al. 2012

Stroke

2,957

1,375

View full text Add to dashboard Cite

Purpose— The aim of this guideline is to present current and comprehensive recommendations for the diagnosis and treatment of aneurysmal subarachnoid hemorrhage (aSAH). Methods— A formal literature search of MEDLINE (November 1, 2006, through May 1, 2010) was performed. Data were synthesized with the use of evidence tables. Writing group members met by teleconference to discuss data-derived recommendations. The American Heart Association Stroke Council's Levels of Evidence grading algorithm was used to grade each recommendation. The guideline draft was reviewed by 7 expert peer reviewers and by the members of the Stroke Council Leadership and Manuscript Oversight Committees. It is intended that this guideline be fully updated every 3 years. Results— Evidence-based guidelines are presented for the care of patients presenting with aSAH. The focus of the guideline was subdivided into incidence, risk factors, prevention, natural history and outcome, diagnosis, prevention of rebleeding, surgical and endovascular repair of ruptured aneurysms, systems of care, anesthetic management during repair, management of vasospasm and delayed cerebral ischemia, management of hydrocephalus, management of seizures, and management of medical complications. Conclusions— aSAH is a serious medical condition in which outcome can be dramatically impacted by early, aggressive, expert care. The guidelines offer a framework for goal-directed treatment of the patient with aSAH.

show abstract

“…However, the majority of patients in their studies were in good condition on admission. Other studies have shown that the factors associated with hyponatremia are predictors for poor outcome in aSAH patients,12 13 In addition, Chandy et al suggested that hyponatremia was related with cerebral vasospasm, an independent predictor of poor outcome 14. Since there is a different prognosis between low-grade and high-grade aSAH patients, and a correct understanding of the predictive value of hyponatremia may influence clinical management decisions in the different aSAH patients, we try to explain this uncertainty about the role of hyponatremia within the different subgroups by hypothesising that hyponatremia is a predictor for bad outcome only in high-grade aSAH patients (the World Federation of Neurological Surgeons Scale (WFNS) grade 4 or 5).…”

mentioning

confidence: 99%

A predictive value of hyponatremia for poor outcome and cerebral infarction in high-grade aneurysmal subarachnoid haemorrhage patients

Zheng

Qiu

Jin

et al. 2010

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

show abstract

Hyponatremia and cerebrovascular spasm in aneurysmal subarachnoid hemorrhage

Abstract: In patients with SAH, hyponatremia is associated with a significantly greater risk of developing CVS and may precede CVS by at least one day.

Cited by 45 publications

References 16 publications

Clinical and Predictive Significance of Hyponatremia After Aneurysmal Subarachnoid Hemorrhage

Clinical and Predictive Significance of Hyponatremia After Aneurysmal Subarachnoid Hemorrhage

Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage

A predictive value of hyponatremia for poor outcome and cerebral infarction in high-grade aneurysmal subarachnoid haemorrhage patients

Contact Info

Product

Resources

About