Hyponatremia and In-Hospital Mortality in Patients Admitted for Heart Failure (from the ATTEND Registry)

Sato, Naoki; Gheorghiade, Mihai; Kajimoto, Katsuya; Munakata, Ryo; Minami, Yuichiro; Mizuno, Masayuki; Aokage, Toshiyuki; Asai, Kuniya; Sakata, Yasushi; Yumino, Dai; Mizuno, Kyoichi; Takano, Teruo

doi:10.1016/j.amjcard.2012.12.019

Cited by 79 publications

(68 citation statements)

References 15 publications

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“…In addition, serum sodium levels must be cautiously monitored because TLV was developed as a medication to treat hyponatremia (14). That said, hyponatremia has been reported to worsen the prognosis for ADHF (15,16). The use of TLV might have a renal protective effect and elevate serum sodium levels, but long-term use of TLV did not alleviate renal dysfunction or reduce serum sodium levels in the current study.…”

Section: The Severity Of Heart Failure In Subjectsmentioning

confidence: 39%

Experience with long-term administration of tolvaptan to patients with acute decompensated heart failure

Kiuchi

Fujii

Hisatake

et al. 2017

DD&T

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Section: The Severity Of Heart Failure In Subjectsmentioning

confidence: 39%

Experience with long-term administration of tolvaptan to patients with acute decompensated heart failure

Kiuchi

Fujii

Hisatake

et al. 2017

DD&T

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“…In observational studies, registries and post-hoc analyses of randomized clinical trials, it was reported to correlate with all-cause and cardiac mortality (both in-hospital and long-term) as well as with the risk of re-hospitalization for HF [12,[15][16][17][18][19][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

“…Hyponatremia is frequently observed in patients with severe HF. Data from registries and randomized controlled trials indicate that 12-27% of patients admitted to hospital for HF are hyponatremic [15][16][17][18][19]. In HF, hyponateremia is believed to result from increased concentrations of antidiuretic hormone (ADH, vasopressin), the secretion of which is stimulated by reduced systemic arterial blood pressure due to a low cardiac output, even in patients with volume overload and fluid retention.…”

Section: Discussionmentioning

confidence: 99%

Resting heart rate at hospital admission and its relation to hospital outcome in patients with heart failure

et al. 2014

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Background: Resting heart rate (HR) has been proven to influence long-term prognosis in patients with chronic heart failure (HF). (OR 1.594 [per 10 bpm]; p = 0.0248) and lower natrium concentration at admission (OR 0.767 [per 1 mmol/L]; p = 0.0162) were the only independent predictors of in-hospital mortality. Conclusions: In patients with HF, higher resting HR at hospital admission is associated with increased in-hospital mortality. (Cardiol J 2014; 21, 4: 425-433)

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“…Moreover, hospital‐acquired hyponatremia has been reported to occur in approximately 15–25% ADHF patients as a result of decongestive treatment 5, 6. Whatever the aetiology, hyponatremia has been suggested as a predictor of short‐term outcomes in hospitalized patients with worsening HF 7, 8, 9…”

Section: Introductionmentioning

confidence: 99%

On admission serum sodium and uric acid levels predict 30 day rehospitalization or death in patients with acute decompensated heart failure

et al. 2017

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AimsA considerable proportion of hospitalized patients for acute decompensated heart failure will be readmitted or die in short‐term follow‐up. In the present study, we aimed to assess the role of admission sodium (Na) and uric acid (UA) levels in the prediction of 30 day post‐discharge heart failure readmission or all‐cause mortality in advanced heart failure patients admitted with acute decompensation.Methods and resultsOne hundred and forty consecutive advanced heart failure patients who were admitted for a recent cardiac decompensation were enrolled in this prospective study. Serum Na and UA levels remained statistically unchanged during index admission (P = 0. 54 and 0.19, respectively). Within 30 days post‐discharge, composite end point of heart failure rehospitalization or all‐cause death occurred in 62 (44.3%) patients (event group). Length of stay was statistically similar between patients in the event and non‐event groups (P = 0.38). No correlations were also found between length of stay and left ventricular ejection fraction, serum Na, UA, erythrocyte sedimentation rate (ESR), high‐sensitivity C‐reactive protein (hs‐CRP), creatinine, and N‐terminal pro b‐type natriuretic peptide (NT‐proBNP) levels (all P > 0.05). Lower left ventricular ejection fraction and Na and higher UA on admission were significantly associated with 30 day event both in univariate and multivariate analyses.ConclusionsGiven the predictive role of baseline Na and UA for early post‐discharge outcome and the absence of significant changes in their levels during initial hospitalization, admission Na and UA can be considered as prognosticators of acute decompensated heart failure, which their prognostic significance cannot be affected by routine acute heart failure therapy.

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Hyponatremia and In-Hospital Mortality in Patients Admitted for Heart Failure (from the ATTEND Registry)

Cited by 79 publications

References 15 publications

Experience with long-term administration of tolvaptan to patients with acute decompensated heart failure

Experience with long-term administration of tolvaptan to patients with acute decompensated heart failure

Resting heart rate at hospital admission and its relation to hospital outcome in patients with heart failure

On admission serum sodium and uric acid levels predict 30 day rehospitalization or death in patients with acute decompensated heart failure

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