Hyponatremia at admission is associated with in-hospital death in patients with hip fracture

Hagino, Tetsuo; Ochiai, Satoshi; Watanabe, Yoshiyuki; Senga, Shinya; Saito, Masanori; Takayama, Yoshihiro; Wako, Masanori; Ando, Takashi; Satô, Eiichi; Haro, Hirotaka

doi:10.1007/s00402-013-1693-x

Cited by 36 publications

(25 citation statements)

References 23 publications

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“…Hyponatraemia warrants investigation and assessment as mortality risk increases with even mild derangement and is associated with increased length of hospital stay [13]. Admission hyponatraemia has been associated with increased in hospital death in hip fracture patients with an odds ratio of 3.64 [14].…”

Section: Discussionmentioning

confidence: 99%

Aetiology of hyponatraemia after hip fracture

Grant

Winter

McGlynn

et al. 2015

Eur Orthop Traumatol

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In this study, we report the prevalence and aetiology of hyponatraemia after surgery for hip fracture. We conducted a retrospective analysis of 144 consecutive patients who underwent surgery after sustaining a hip fracture. Data were collected from medical case records, operative notes and electrolyte results. Univariate and logistic regression analysis was conducted in order to identify significant independent risk factors for the development of hyponatraemia. Mild hyponatraemia was relatively common affecting 19 % (28/ 144) of patients pre-operatively and 28 % (40/144) post-operatively. However, moderate/severe hyponatraemia (plasma sodium concentration <130 mmol/l) was uncommon, affecting 1 % (2/144) of patients at the time of admission and 6 % (9/144) of patients post-operatively. Univariate analysis identified: female gender, pre-operative hyponatraemia, hypotonic fluid administration and thiazide diuretic use as being associated with the development of post-operative hyponatraemia. Age had no statistically significant association. Logistic regression analysis identified female gender, pre-operative hyponatraemia and hypotonic fluid administration being significant, independent risk factors for the development of hyponatraemia. Age and thiazide diuretics both had positive risk associations; however, these were not statistically significant. Mild hyponatraemia is a common finding in hip fracture patients; however, more severe cases are relatively rare. Preoperative hyponatraemia and hypotonic fluid administration were the only modifiable risk factors identified.

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Section: Discussionmentioning

confidence: 99%

Aetiology of hyponatraemia after hip fracture

Grant

Winter

McGlynn

et al. 2015

Eur Orthop Traumatol

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show abstract

“…Experimental and clinical evidence have indicated in recent years that hyponatremia may negatively affect bone health [5,6,[8][9][10][11][12][15][16][17]. This study focused on the comprehension of the mechanisms leading to bone frailty in the presence of reduced [Na ? ]…”

Section: Discussionmentioning

confidence: 99%

“…Osteoporotic fractures and their complications are a major cause of death in industrialized countries and represent a risk factor for increased mortality in both sexes [7]. Over the last few years, many studies have confirmed the association between mild chronic hyponatremia and fractures, but neurological alterations involving gait and cognitive functions only partially explain this correlation [5,6,[8][9][10][11]. On the other hand, there is now emerging literature suggesting that chronic hyponatremia represents an independent risk factor for osteoporosis by directly promoting bone loss.…”

Section: Introductionmentioning

confidence: 95%

Low extracellular sodium promotes adipogenic commitment of human mesenchymal stromal cells: a novel mechanism for chronic hyponatremia-induced bone loss

et al. 2015

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Editor-in-Chief: A. Giustina ▶ Covers leading topics in endocrinology ▶ Includes Hormones of reproduction, metabolism, growth, and ion balance ▶ Offers the latest on insulin and diabetes ▶ Presents newly-emerging endocrine-related topics ▶ 94% of authors who answered a survey reported that they would definitely publish or probably publish in the journal againWell-established as a major journal in today's rapidly advancing experimental and clinical research, Endocrine publishes full-length original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical (including proof of concept studies and clinical trials) research in all the different fields of endocrinology and metabolism. Endocrine covers the following leading topics in Endocrinology such as: Neuroendocrinology, Pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, type 1 and type 2 diabetes, hormones of male and female reproduction, and of HPA axis, pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.

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“…Improved survival was noted in patients with a shorter time to surgery and in patients with normal cognitive status. Hyponatraemia on admission has recently been associated with in-hospital death in elderly patients admitted with hip fractures [21].…”

Section: Discussionmentioning

confidence: 99%

Analysis of hyponatraemia associated post-operative mortality in 3897 hip fracture patients

Tinning

Cochrane

Singer

2015

Injury

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Hyponatremia at admission is associated with in-hospital death in patients with hip fracture

Abstract: Hyponatremia at admission is prevalent in old aged patients with fracture, and is related to in-hospital death.

Cited by 36 publications

References 23 publications

Aetiology of hyponatraemia after hip fracture

Aetiology of hyponatraemia after hip fracture

Low extracellular sodium promotes adipogenic commitment of human mesenchymal stromal cells: a novel mechanism for chronic hyponatremia-induced bone loss

Analysis of hyponatraemia associated post-operative mortality in 3897 hip fracture patients

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