Hyponatremia, Hypokalemia, and Fragility Fractures in Old Patients: More than an Association?

Schiara, Laura Anna Maria; Moirano, Giovenale; Grosso, Erica Del; Richiardi, Lorenzo; Tibaldi, Michela; Spertino, Elena; Vezza, Carlotta; Isaia, Giovanni Carlo; Massaia, Massimiliano

doi:10.1007/s00223-020-00675-6

Cited by 13 publications

(19 citation statements)

References 35 publications

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“…In two studies (20,40) no association between hyponatremia and fragility fractures was found. Some differences in comorbidities between hyponatremic and normonatremic subjects may affect results representing a selection bias in (40) as previously discussed.…”

Section: Discussionmentioning

confidence: 92%

“…Three were prospective cohort study (3,20,40,51). The others were retrospective studies (9,18,19,35,36,(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55), and one included both a retrospective and prospective part (20). One study included only men (51) and two only women (18,50) (Table 2).…”

Section: Hyponatremia Osteoporosis and Fracturesmentioning

confidence: 99%

“…Twenty articles published between 2008 and 2020 were included (3,9,(18)(19)(20)35,36,40,(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55). Three were prospective cohort study (3,20,40,51).…”

Section: Hyponatremia Osteoporosis and Fracturesmentioning

confidence: 99%

“…(21). Some studies focused on the association between increased mortality and hyponatremia (3,9,20,22,23), suggesting that, this electrolytic disorder, may be regarded rather as a general marker of poor health status than as a causal factor of unhealthy aging.…”

Section: Introductionmentioning

confidence: 99%

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Hyponatremia and aging-related diseases: key player or innocent bystander? A systematic review.

Fratangelo

Nguyen

2022

Preprint

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Purpose. Hyponatremia is frequent in older age, whether it is a key player, a surrogate marker, or an innocent bystander in age related diseases is still unclear. Method. To further understand the role of hyponatremia in falls, osteoporosis, fractures, and cognitive impairment in old patients, we conducted a systematic literature review. The protocol of this study is available on the International prospective register of systematic reviews (PROSPERO, number CRD42021218389). MEDLINE, EMBASE and PsycINFO database were searched. Three reviewers identified studies meeting inclusion criteria and check decisions. Each study was independently evaluated by two reviewers, discrepancies between the two reviewers were solved by the third. Two hundred and fifteen articles were retrieved. Thirty-two were included in the review. Results. The majority of the studies found a significant association between hyponatremia and falls even after correction for confounding factors. Some studies suggested an association between persistent hyponatremia and increased osteoporosis and fracture risk. On the contrary, the evidence of an association between hyponatremia and cognitive impairment is lacking. Conclusion. Here we suggest that hyponatremia may be regarded as a marker of unhealthy aging and a confounder rather than a causal factor or an innocent bystander for falls and fractures. As regards cognitive impairment, the evidence provided until now, are not sufficient to explain a real role of hyponatremia that may be regarded rather as an innocent bystander in neurodegeneration.

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Section: Discussionmentioning

confidence: 92%

Section: Hyponatremia Osteoporosis and Fracturesmentioning

confidence: 99%

“…Twenty articles published between 2008 and 2020 were included (3,9,(18)(19)(20)35,36,40,(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55). Three were prospective cohort study (3,20,40,51).…”

Section: Hyponatremia Osteoporosis and Fracturesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hyponatremia and aging-related diseases: key player or innocent bystander? A systematic review.

Fratangelo

Nguyen

2022

Preprint

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“…Similarly, electrolyte disturbances are also highly prevalent in this population. This situation may be exacerbated by prescribed drugs or intravenous infusions, and may potentially interact with other factors contributing to the occurrence of adverse events [139,140]. Additionally, coagulation screening through prothrombin time and activated partial thromboplastin time is necessary to determine anaesthesiologic and surgical eligibility.…”

Section: Perioperative Blood Testsmentioning

confidence: 99%

Orthogeriatric co-management for the care of older subjects with hip fracture: recommendations from an Italian intersociety consensus

Vincentis

Behr²,

Bellelli

et al. 2021

Aging Clin Exp Res

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Background Health outcomes of older subjects with hip fracture (HF) may be negatively influenced by multiple comorbidities and frailty. An integrated multidisciplinary approach (i.e. the orthogeriatric model) is, therefore, highly recommended, but its implementation in clinical practice suffers from the lack of shared management protocols and poor awareness of the problem. The present consensus document has been implemented to address these issues. Aim To develop evidence-based recommendations for the orthogeriatric co-management of older subjects with HF. Methods A 20-member Expert Task Force of geriatricians, orthopaedics, anaesthesiologists, physiatrists, physiotherapists and general practitioners was established to develop evidence-based recommendations for the pre-, peri-, intra-and postoperative care of older in-patients (≥ 65 years) with HF. A modified Delphi approach was used to achieve consensus, and the U.S. Preventive Services Task Force system was used to rate the strength of recommendations and the quality of evidence. Results A total of 120 recommendations were proposed, covering 32 clinical topics and concerning preoperative evaluation (11 topics), perioperative (8 topics) and intraoperative (3 topics) management, and postoperative care (10 topics). Conclusion These recommendations should ease and promote the multidisciplinary management of older subjects with HF by integrating the expertise of different specialists. By providing a convenient list of topics of interest, they might assist in identifying unmet needs and research priorities.

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Minerals and Sarcopenia in Older Adults: An Updated Systematic Review

van Dronkelaar,

Fultinga,

Hummel

et al. 2023

Journal of the American Medical Directors Association

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Hyponatremia, Hypokalemia, and Fragility Fractures in Old Patients: More than an Association?

Cited by 13 publications

References 35 publications

Hyponatremia and aging-related diseases: key player or innocent bystander? A systematic review.

Hyponatremia and aging-related diseases: key player or innocent bystander? A systematic review.

Orthogeriatric co-management for the care of older subjects with hip fracture: recommendations from an Italian intersociety consensus

Minerals and Sarcopenia in Older Adults: An Updated Systematic Review

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