Hyponatremia in Critically Ill Patients

Vachharajani, Tushar J.; Zaman, Forhad Akhtar; Abreo, Kenneth

doi:10.1177/0885066602239119

Cited by 39 publications

(19 citation statements)

References 43 publications

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“…Intravenous infusion of a slow 3 % hypertonic sodium chloride infusion (typically 1–2 mmol/L/h to prevent pontine myelinolysis) is indicated until serum sodium rises to 125 mmol/ [2, 18, 22, 23] correcting any cerebral oedema and reducing the risk of systemic complications. Acute hyponatraemia below 120 mm/l and/or acute symptomatic hyponatraemia should be treated with a 100 ml bolus of 3 % saline over 10 min and this can be repeated up to three times, followed by an infusion as described above.…”

Section: Complications Of Distending Mediamentioning

confidence: 99%

BSGE/ESGE guideline on management of fluid distension media in operative hysteroscopy

et al. 2016

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Section: Complications Of Distending Mediamentioning

confidence: 99%

BSGE/ESGE guideline on management of fluid distension media in operative hysteroscopy

et al. 2016

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“…Hyponatremia is common in the ED, but the diagnostic approach is often challenging [29]. In the differential diagnosis of the syndrome of inappropriate antidiuretic hormone hypersecretion and sodium depletion, copeptin showed promising results [30].…”

Section: Introductionmentioning

confidence: 99%

The role of copeptin as a diagnostic and prognostic biomarker for risk stratification in the emergency department

Nickel

Bingisser

Morgenthaler

2012

BMC Med

138

111

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The hypothalamic-pituitary-adrenal axis is activated in response to stress. One of the activated hypothalamic hormones is arginine vasopressin, a hormone involved in hemodynamics and osmoregulation. Copeptin, the C-terminal part of the arginine vasopressin precursor peptide, is a sensitive and stable surrogate marker for arginine vasopressin release. Measurement of copeptin levels has been shown to be useful in a variety of clinical scenarios, particularly as a prognostic marker in patients with acute diseases such as lower respiratory tract infection, heart disease and stroke. The measurement of copeptin levels may provide crucial information for risk stratification in a variety of clinical situations. As such, the emergency department appears to be the ideal setting for its potential use. This review summarizes the recent progress towards determining the prognostic and diagnostic value of copeptin in the emergency department.

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“…Severe hyponatremia (typically defined as serum sodium G125 mmol/L) can cause confusion, seizures, hallucinations, coma, and respiratory arrest. 1 Mild-to-moderate hyponatremia causes milder symptoms including headache, difficulty concentrating, impaired memory, muscle cramps, and weakness. 3 Therefore, the available treatment options for SIADH aim at correcting the serum sodium.…”

Section: Casementioning

confidence: 99%

Use of Conivaptan for Refractory Syndrome of Inappropriate Secretion of Antidiuretic Hormone in a Pediatric Patient

Peters

Kuhn²,

Gardner³

et al. 2013

Pediatric Emergency Care

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The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is the most common form of hyponatremia in hospitalized patients. The available treatment options for SIADH are limited and not completely effective. A more recent and specific option for treatment of hyponatremia secondary to SIADH are the vasopressin-receptor antagonists. Conivaptan, an intravenous vasopressin-receptor antagonist, is Food and Drug Administration approved for the treatment of euvolemic and hypervolemic hyponatremia in adults; however, data regarding its use in pediatric patients are extremely limited. Conivaptan played an integral role in the treatment of hyponatremia in this situation when conventional treatment modalities were ineffective. This patient did not experience any adverse effects, and his sodium level corrected slowly over a 24-hour period, avoiding complications of rapid sodium correction.

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Hyponatremia in Critically Ill Patients

Cited by 39 publications

References 43 publications

BSGE/ESGE guideline on management of fluid distension media in operative hysteroscopy

BSGE/ESGE guideline on management of fluid distension media in operative hysteroscopy

The role of copeptin as a diagnostic and prognostic biomarker for risk stratification in the emergency department

Use of Conivaptan for Refractory Syndrome of Inappropriate Secretion of Antidiuretic Hormone in a Pediatric Patient

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