Hyponatremia in elderly patients with fragility fractures of the proximal femur: a cross-sectional study

Rocha, Aída Fernanda Batista; Sá, Marcus Villander Barros de Oliveira; Júnior, Ubiraçé Fernando Elihimas

doi:10.1590/2175-8239-jbn-2019-0019

Cited by 5 publications

(5 citation statements)

References 40 publications

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“…In our study, it was determined that there was no statistically significant difference between in-hospital mortality and one-year survival results between hyponatremic and normonatremic patient groups. Studies previously reported in the literature reveal that chronic hyponatremia is an independent factor that increases the incidence of femoral fracture 15,16 . In recent years, more studies have listed hyponatremia among the pathogenic factors of osteoporosis 17,18 .…”

Section: Discussionmentioning

confidence: 87%

The incidence of hyponatremia in hospitalized patients due to hip fracture and its effect on mortality

Kayaokay

Yurtlu

2023

Cukurova Medical Journal

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Purpose: Hyponatremia is associated with high morbidity and mortality in elderly patients. This study aimed to investigate the incidence of hyponatremia and its effects on the duration of hospitalization, in-hospital and 1-year mortality in elderly patients admitted to the hospital due to hip fracture. Materials and Methods: After the approval of the ethics committee, patients over the age 65 and had hip surgery between January-December 2020 were retrospectively analyzed. The age, gender, fracture type, current comorbidities, and American Society of Anesthesiology physical status scores of the patients were recorded. Plasma Na, K, and Ca values in admission to hospital were recorded. Patients with hyponatremia and normonatremia were compared in terms of demographic data, comorbidities, duration of hospitalization, in-hospital, and 1-year mortality rates. Results: Of the total 253 patients, 52(%20.5) had hyponatremia at hospital admission. Demographic data were similar in hyponatremic and normonatremic patients. In hyponatremia group mean Na values were 131.13±3.96 mmol/L and significantly lower than normonatremia group (138.73±2.27). In the hyponatremic group, diabetes mellitus was observed in 23 (44%) patients, and congestive heart failure was observed in 9 (17%) patients, which was higher than the normonatremic group. The preoperative and total duration of hospitalization was 5.21±2.68 and 9.92±4.49 days respectively and higher in patients with hyponatremia. In-hospital and 1-year mortality rates were similar between the groups. Conclusion: The incidence of hyponatremia was found to be 20.5% in patients with hip fractures, and both the preoperative and total hospital stays were prolonged in these patients. Although mortality rates were similar in this study, hyponatremia requires careful follow-up and early treatment in these patients, since it is known that the length of hospital stay increases mortality.

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Section: Discussionmentioning

confidence: 87%

The incidence of hyponatremia in hospitalized patients due to hip fracture and its effect on mortality

Kayaokay

Yurtlu

2023

Cukurova Medical Journal

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“…Moreover, many drug groups such as thiazide diuretics, Renin-Angiotensin-Aldosterone system inhibitors, antidepressants, PPIs, and antipsychotics may cause inappropriate ADH syndrome and hyponatremia in this age group [19,20]. Several studies have shown that loop diuretics are linked to osteoporosis and fracture risk [5,16]. Diuretics eliminate sodium and calcium either indirectly via renal excretion or directly via bone resorption from hyponatremia [14,21].…”

Section: Discussionmentioning

confidence: 99%

“…A fragility fracture is a fracture resulting from a fall from standing height or less. These fractures, which most commonly occur in the hip, spine, or wrist, are an indication that the bones of the body have been weakened by underlying conditions [4,5]. The risk factors for hip fragility fractures are advanced age, sex, race, weight loss, lack of exercise, nutritional disorders, metabolic disorders, smoking, and alcohol use.…”

Section: Introductionmentioning

confidence: 99%

“…Less commonly, other metabolic disorders such as osteomalacia and renal osteodystrophy, oncological diseases, and endocrinological disorders like diabetes mellitus (DM) and hyperthyroidism are also related to hip fractures. In addition to changes in bone mass, falls secondary to muscle strength and coordination problems, as well as inadequate absorption of fall energy play role in developing fall-associated fractures in the elderly [5]. Additionally, hyponatremia and hyponatremiainduced imbalance may be exemplified as metabolic disorders predisposing to falls [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Etiology and prevalence of hyponatremia in geriatric patients with fragility hip fractures

Emektar,

Dagar,

Uzunosmanoğlu

et al. 2021

Ann Clin Anal Med

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“…We excluded 94 articles for violation of eligibility criteria; hence, 41 full text articles were reviewed as previously described. After reading the full text article, nine articles (25)(26)(27)(28)(29)(30)(31)(32)(33) were excluded as non-relevant for the research question (Fig. 1).…”

Section: Data Extraction and Analysismentioning

confidence: 99%

Hyponatremia and aging-related diseases: key player or innocent bystander? A systematic review.

Fratangelo

Nguyen

2022

Preprint

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Purpose. Hyponatremia is frequent in older age, whether it is a key player, a surrogate marker, or an innocent bystander in age related diseases is still unclear. Method. To further understand the role of hyponatremia in falls, osteoporosis, fractures, and cognitive impairment in old patients, we conducted a systematic literature review. The protocol of this study is available on the International prospective register of systematic reviews (PROSPERO, number CRD42021218389). MEDLINE, EMBASE and PsycINFO database were searched. Three reviewers identified studies meeting inclusion criteria and check decisions. Each study was independently evaluated by two reviewers, discrepancies between the two reviewers were solved by the third. Two hundred and fifteen articles were retrieved. Thirty-two were included in the review. Results. The majority of the studies found a significant association between hyponatremia and falls even after correction for confounding factors. Some studies suggested an association between persistent hyponatremia and increased osteoporosis and fracture risk. On the contrary, the evidence of an association between hyponatremia and cognitive impairment is lacking. Conclusion. Here we suggest that hyponatremia may be regarded as a marker of unhealthy aging and a confounder rather than a causal factor or an innocent bystander for falls and fractures. As regards cognitive impairment, the evidence provided until now, are not sufficient to explain a real role of hyponatremia that may be regarded rather as an innocent bystander in neurodegeneration.

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Hyponatremia in elderly patients with fragility fractures of the proximal femur: a cross-sectional study

Cited by 5 publications

References 40 publications

The incidence of hyponatremia in hospitalized patients due to hip fracture and its effect on mortality

The incidence of hyponatremia in hospitalized patients due to hip fracture and its effect on mortality

Etiology and prevalence of hyponatremia in geriatric patients with fragility hip fractures

Hyponatremia and aging-related diseases: key player or innocent bystander? A systematic review.

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