2021
DOI: 10.1186/s41016-021-00231-7
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Hypoperfusion assessed by pressure reactivity index is associated with delayed cerebral ischemia after subarachnoid hemorrhage: an observational study

Abstract: Background Dysfunction of cerebral autoregulation is one of the pathophysiological mechanisms that causes delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). Pressure reactivity index (PRx) have been confirmed to reflect the level of cerebral autoregulation and used to derive optimal cerebral perfusion pressure (CPPopt). The goal of this study is to explore the associations between autoregulation, CPPopt, PRx, and DCI. Methods Cont… Show more

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Cited by 6 publications
(3 citation statements)
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“…As such, knowledge of CPPopt (trends) could help to individualize CPP targets and recognize individual cerebral ‘hypoperfusion’ before symptom development. Fan et al [20] reported a similar finding, wherein patients with DCI had longer episodes of cerebral ‘hypoperfusion’ than patients without DCI [20]. There are currently few studies in aSAH suggesting an association of deviation from CPPopt with poor clinical outcome [20,21].…”
Section: Recent Developments In Aneurysmal Subarachnoid Hemorrhagementioning
confidence: 86%
See 1 more Smart Citation
“…As such, knowledge of CPPopt (trends) could help to individualize CPP targets and recognize individual cerebral ‘hypoperfusion’ before symptom development. Fan et al [20] reported a similar finding, wherein patients with DCI had longer episodes of cerebral ‘hypoperfusion’ than patients without DCI [20]. There are currently few studies in aSAH suggesting an association of deviation from CPPopt with poor clinical outcome [20,21].…”
Section: Recent Developments In Aneurysmal Subarachnoid Hemorrhagementioning
confidence: 86%
“…Fan et al [20] reported a similar finding, wherein patients with DCI had longer episodes of cerebral ‘hypoperfusion’ than patients without DCI [20]. There are currently few studies in aSAH suggesting an association of deviation from CPPopt with poor clinical outcome [20,21]. The largest retrospective study up to date could not confirm this relationship [22 ▪ ].…”
Section: Recent Developments In Aneurysmal Subarachnoid Hemorrhagementioning
confidence: 93%
“…Several CA indices for continuous monitoring of CA, such as the mean velocity index, have been evaluated as tools for continuous assessment of CA during the acute management of patients with aSAH in clinical practice [ 13 ]. The PRx was applied in this study to ascertain CA capacity and is often used for this purpose [ 14 16 ]. Hence, the results of this study provide first evidence as a foundation for further prospective evaluation but do not allow for generalization.…”
Section: Discussionmentioning
confidence: 99%