Hypoperfusion in the supplementary motor area, dorsolateral prefrontal cortex and insular cortex in Parkinson's disease

Kikuchi, Akio; Takeda, Atsushi; Kimpara, Teiko; Nakagawa, Manabu; Kawashima, Ryuta; Sugiura, Motoaki; Kinomura, Shigeo; Fukuda, Hiroshi; Chida, Keiji; Okita, Naoshi; Takase, Sadao; Itoyama, Yasuto

doi:10.1016/s0022-510x(01)00641-4

Cited by 78 publications

(52 citation statements)

References 47 publications

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“…Various authors have reported normal flow or only a localized reduction in cerebral perfusion in nondemented patients with PD, and our present results for nondemented PD patients appear consistent with those of previous reports [4,5,23,28,29] in which rCBF was reduced in the parietal or frontal cortex, or the thalamus. Although some investigators have reported that intravenous bolus administration of L-DOPA increases CBF [30], we suspect that our results were little affected by L-DOPA, dopamine agonist, and anticholinergic therapy, since many authors [28,31,32] have reported that cortical blood flow in PD is not affected by the long-term oral administration of these drugs. Perfusion deficits in PDD, DLB, and AD, comparing 3D-SSP of Z-score maps constructed using values normalized to cerebellar perfusion between PDD, DLB, and AD patients and to normal controls.…”

Section: Discussionsupporting

confidence: 93%

Cerebral Blood Flow in Parkinson’s Disease, Dementia with Lewy Bodies, and Alzheimer’s Disease according to Three-Dimensional Stereotactic Surface Projection Imaging

Kasama¹,

Tachibana²,

Kawabata³

et al. 2005

Dement Geriatr Cogn Disord

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Regional brain perfusion was analyzed using single-photon emission computed tomography with three-dimensional stereotactic surface projections (3D-SSP) in 69 patients with Parkinson’s disease (PD), 16 patients with dementia with Lewy bodies (DLB) and 15 patients with Alzheimer’s disease (AD), and compared with that in 24 age-equivalent normal subjects. Nondemented PD patients revealed less parietal and frontal flow than controls. With mental impairment, flow reduction extended to other areas including occipital regions. PD with dementia and DLB showed similar reduction patterns, although frontal flow showed a greater reduction in DLB. AD showed little occipital reduction, but a severe parieto-temporal reduction. Thus, 3D-SSP appears to be useful in the detection of cortical lesions and the differential diagnosis of patients with cognitive impairment.

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Section: Discussionsupporting

confidence: 93%

Cerebral Blood Flow in Parkinson’s Disease, Dementia with Lewy Bodies, and Alzheimer’s Disease according to Three-Dimensional Stereotactic Surface Projection Imaging

Kasama¹,

Tachibana²,

Kawabata³

et al. 2005

Dement Geriatr Cogn Disord

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“…For example, the performance of novelty seeking in patients with PD correlated with the insular cortical dopamine D2 receptor availability [Kaasinen et al, 2004]. In addition, the regional cerebral blood flow (rCBF) in the insula decreases in PD [Hsu et al, 2007;Kikuchi et al, 2001], and is negatively correlated with the motor UPDRS [Hsu et al, 2007]. It has been suggested that the insular hypoperfusion has a relation with disease severity and participates in motor performance, and is consistent with the extended predictions of the basal ganglia circuit model [Hsu et al, 2007].…”

Section: Cmentioning

confidence: 58%

Functional connectivity of cortical motor areas in the resting state in Parkinson's disease

Wu¹,

Long

Wang

et al. 2010

Human Brain Mapping

185

147

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Parkinson's disease (PD) patients have difficulty in initiating movements. Previous studies have suggested that the abnormal brain activity may happen not only during performance of self-initiated movements but also in the before movement (baseline or resting) state. In the current study, we investigated the functional connectivity of brain networks in the resting state in PD. We chose the rostral supplementary motor area (pre-SMA) and bilateral primary motor cortex (M1) as "seed" regions, because the pre-SMA is important in motor preparation, whereas the M1 is critical in motor execution. FMRIs were acquired in 18 patients and 18 matched controls. We found that in the resting state, the pattern of connectivity with both the pre-SMA or the M1 was changed in PD. Connectivity with the pre-SMA in patients with PD compared to normal subjects was increased connectivity to the right M1 and decreased to the left putamen, right insula, right premotor cortex, and left inferior parietal lobule. We only found stronger connectivity in the M1 with its own local region in patients with PD compared to controls. Our findings demonstrate that the interactions of brain networks are abnormal in PD in the resting state. There are more connectivity changes of networks related to motor preparation and initiation than to networks of motor execution in PD. We postulate that these disrupted connections indicate a lack of readiness for movement and may be partly responsible for difficulty in initiating movements in PD.

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“…[23][24][25][26][27][28][29] Dysfunction of medial frontal areas, which presumably results from altered basal ganglia interactions due to nigrostriatal dopaminergic loss, plays a role in impaired motor performance (ie, hypokinesia). 1,30 This type of functional cortical deafferentation is supported by brain imaging studies showing diminished regional blood flow in the supplementary motor area 24 and the prefrontal region. 23 Morphologic longitudinal imaging studies have shown significant annual brain volume loss in patients with PD without dementia compared with control subjects.…”

Section: Discussionmentioning

confidence: 88%

Altered Diffusion in the Frontal Lobe in Parkinson Disease

Kendi¹,

Lehericy²,

Luciana³

et al. 2008

AJNR Am J Neuroradiol

176

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Hypoperfusion in the supplementary motor area, dorsolateral prefrontal cortex and insular cortex in Parkinson's disease

Cited by 78 publications

References 47 publications

Cerebral Blood Flow in Parkinson’s Disease, Dementia with Lewy Bodies, and Alzheimer’s Disease according to Three-Dimensional Stereotactic Surface Projection Imaging

Cerebral Blood Flow in Parkinson’s Disease, Dementia with Lewy Bodies, and Alzheimer’s Disease according to Three-Dimensional Stereotactic Surface Projection Imaging

Functional connectivity of cortical motor areas in the resting state in Parkinson's disease

Altered Diffusion in the Frontal Lobe in Parkinson Disease

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