Hypophosphatemia and Rhabdomyolysis

Knöchel, James P.; Barcenas, Camilo G.; Cotton, James R.; Fuller, Thomas W.; Haller, Ronald G.; Carter, N. W.

doi:10.1172/jci109244

Cited by 150 publications

(71 citation statements)

References 9 publications

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“…In experimental studies, hypophosphataemia was shown to cause rhabdomyolysis. 203 Hypophosphataemia-induced rhabdomyolyis is usually reported in patients with alcoholism, anorexia nervosa, theophylline toxicity, acute barium poisoning, toluene sniffing and after gastric surgery. 204,205 In one study, increased CK was reported in 36% of hypophosphataemic patients.…”

Section: Consequences Of Hypophosphataemiamentioning

confidence: 99%

Phosphate homeostasis and disorders

2014

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Recent studies of inherited disorders of phosphate metabolism have shed new light on the understanding of phosphate metabolism. Phosphate has important functions in the body and several mechanisms have evolved to regulate phosphate balance including vitamin D, parathyroid hormone and phosphatonins such as fibroblast growth factor-23 (FGF23). Disorders of phosphate homeostasis leading to hypo-and hyperphosphataemia are common and have clinical and biochemical consequences. Notably, recent studies have linked hyperphosphataemia with an increased risk of cardiovascular disease. This review outlines the recent advances in the understanding of phosphate homeostasis and describes the causes, investigation and management of hypo-and hyperphosphataemia.

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Section: Consequences Of Hypophosphataemiamentioning

confidence: 99%

Phosphate homeostasis and disorders

2014

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“…These changes are associated with increased Na+-K+-ATPase activity suggesting that ethanol directly injures sarcolemma allowing for increased Na+ entry (7,8). Hypophosphatemia and hypokalemia are frequent co-existent risk factors for alcohol induced rhabdomyolysis (9).…”

Section: Discussionmentioning

confidence: 99%

Non-Traumatic Rhabdomyolysis With Acute Renal Failure

et al. 2000

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“…Rhabdomyolysis accompanied by anorexia nervosa is very rare (3)(4)(5), and no patient with anorexia nervosa has been reported to manifest hypophosphatemia-induced rhabdomyolysis. However, hypophosphatemia and/or phosphate depletion are common among the causes of rhabdomyolysis reported in cases other than anorexia nervosa (6)(7)(8). Here, we report the first case of anorexia nervosa with acute renal failure resulting from rhabdomyolysis induced by hypophosphatemia and/or phosphate depletion.…”

Section: Introductionmentioning

confidence: 86%

A Case of Anorexia Nervosa with Acute Renal Failure Induced by Rhabdomyolysis; Possible Involvement of Hypophosphatemia or Phosphate Depletion.

et al. 1992

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A 16-year-old girl with anorexia nervosa first presented with malnutrition, liver dys function, and rhabdomyolysis. Administration of fluid and nutrition saved her from the initial critical state, but acute renal failure followed. Laboratory examination revealed intrinsic renal failure induced by rhabdomyolysis. Latent phosphate depletion and refeeding-induced hypo phosphatemia was implicated as the cause of rhabdomyolysis; however coexisting hypotension, dehydration, and liver dysfunction may have contributed to the renal failure. The patient recovered from azotemia by hemodialysis. This is the first reported case of anorexia nervosa with acute renal failure resulting from rhabdomyolysis induced by hypophosphatemia or phosphate depletion. (Internal Medicine 31: 478-482, 1992)

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Hypophosphatemia and Rhabdomyolysis

Cited by 150 publications

References 9 publications

Phosphate homeostasis and disorders

Phosphate homeostasis and disorders

Non-Traumatic Rhabdomyolysis With Acute Renal Failure

A Case of Anorexia Nervosa with Acute Renal Failure Induced by Rhabdomyolysis; Possible Involvement of Hypophosphatemia or Phosphate Depletion.

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