Hypophysectomy in Man: Experiences in Severe Diabetes Mellitus*

Luft, Rolf; Olivecrona, Herbert; Sjögren, Benita

doi:10.1210/jcem-15-4-391

Cited by 77 publications

(25 citation statements)

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“…The treatment of tumours of the ifypophysis has for long been surgical and during the last ten years hypophysectomy has been introduced as a method of dealing with metastases from carcinoma of the breast and for diabetes mellitus associated with angiopathy (LUFT, OLIVECRONA andSJOGREN 1952, 1953). …”

Section: The Sphenoidal Sinusmentioning

confidence: 99%

The Sphenoidal Sinus

Hammer¹,

Rådberg²

1961

Acta Radiologica

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Section: The Sphenoidal Sinusmentioning

confidence: 99%

The Sphenoidal Sinus

Hammer¹,

Rådberg²

1961

Acta Radiologica

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“…The observation that pituitary ablation may reverse or slow the progression of PDR, first made >35 years ago, has raised the question of a role for a pituitary-derived or -dependent factor in this disease process (4)(5)(6)(7)(8). As a consequence of this and of abnormalities in both the quantity and pattern of secretion of growth hormone (GH) in poorly controlled diabetes (9)(10)(11)(12), GH has been suggested as a possible mediator of the effect of pituitary ablation on PDR, potentially via insulin-like growth factors (IGFs) (2,13).…”

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confidence: 99%

Human growth hormone stimulates proliferation of human retinal microvascular endothelial cells in vitro.

Rymaszewski

Cohen

Chomczyński

1991

Proc. Natl. Acad. Sci. U.S.A.

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Growth hormone (GH) has been implicated in the pathogenesis of proliferative diabetic retinopathy. We sought to determine whether this could be mediated by an effect of GH on proliferation of endothelial cells, and, for this purpose, established long-term cultures of human retinal microvascular endothelial cells (hREC) from normal postmortem human eyes. High-purity (>95%) hREC preparations were selected for experiments, based on immunofluorescence with acetylated low density lipoprotein (LDL) and anti-factor VIIIrelated antigen. Growth requirements for these cells were complex, including serum for maintenance at slow growth rates and additional mitogens for more rapid proliferation. Exposure ofhREC to physiologic doses ofhuman GH (hGH) resulted in 100% greater cell number vs. control (P < 0.01) but could be elicited only in the presence of serum. When differing serum conditions were compared, hGH stimulated [3H]thymidine incorporation up to 1.6-to 2.2-fold under each condition and increased DNA content significantly in the presence of human, horse, and fetal calf serum. Depending on the culture conditions used, the threshold hGH concentration for significant stimulation of hREC proliferation was 0.4-4 pg/liter. In contrast, proliferation of human umbilical vein endothelial cells was not significantly altered by hGH added to concentrations as high as 200 pzg/liter. In summary, hREC respond to physiologic concentrations of hGH in vitro with enhanced proliferation. This specific effect of GH on retinal microvascular endothelial cells supports the hypothesis of a role for GH in endothelial cell biology.

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“…These data demonstrated the direct and specific effect of HGH on CBMT diabetic microangiopathy ; basement membrane thickness ; growth hormone Although the multiple factors have been recognized in the genesis of diabetic microangiopathy, a specific role of growth hormone in the progression of the microangiopathy has been emphasized by colleagues (1970, 1971). In fact, a remission of diabetic retinopathy was observed after hypophysectomy (Luft et al 1955) and diabetic microangiopathy could not be demonstrated in pituitary dwarfs with grossly abnormal glucose tolerance (Merimee et al 1970).…”

mentioning

confidence: 99%

“…In fact, a remission of diabetic retinopathy was observed after hypophysectomy (Luft et al 1955) and diabetic microangiopathy could not be demonstrated in pituitary dwarfs with grossly abnormal glucose tolerance (Merimee et al 1970).…”

mentioning

confidence: 99%

Evidence for direct effect of growth hormone on capillary basement membrane thickness.

Oikawa

Maruhama

Gotō

1985

Tohoku J. Exp. Med.

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In order to investigate the direct effect of growth hormone on the capillary basement membrane thickness (CBMT), we performed, in normal and diabetic rats, ultrastructural morphometric studies on the capillaries of the skin loci where the intracutaneous injections of physiologic saline and human growth hormone (HGH) in various concentrations had been repeated daily for 28 days. In the normal group, the injection (0.1 ml daily) of HGH solutions in concentrations of 0.5 ,u g/ml and 2 ,u g/ml did not significantly alter the CBMT, and only at the concentration of 10,ug/ml, HGH significantly (p <0.001) increased the CBMT. In the diabetic group, however, the injection of any of the HGH solutions significantly (p <0.001 0.05) increased the CBMT. In another diabetic rat series, HGH, human albumin, humam menopausal gonadotropin and human globulin (each in a concentration of 10 pg/ml) were repeatedly injected into four separate skin portions for 28 days, and it was found that the net increase in CBMT was most striking in the HGH-treated portion. These data demonstrated the direct and specific effect of HGH on CBMT diabetic microangiopathy ; basement membrane thickness ; growth hormone Although the multiple factors have been recognized in the genesis of diabetic microangiopathy, a specific role of growth hormone in the progression of the microangiopathy has been emphasized by colleagues (1970, 1971). In fact, a remission of diabetic retinopathy was observed after hypophysectomy (Luft et al. 1955) and diabetic microangiopathy could not be demonstrated in pituitary dwarfs with grossly abnormal glucose tolerance (Merimee et al. 1970).Recently, (~sterby et al. (1978) reported that porcine growth hormone administered intramuscularly for 20-40 days increased significantly the glomerular basement membrane thickness in diabetic rats, though they could not clarify

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Hypophysectomy in Man: Experiences in Severe Diabetes Mellitus*

Cited by 77 publications

References 0 publications

The Sphenoidal Sinus

The Sphenoidal Sinus

Human growth hormone stimulates proliferation of human retinal microvascular endothelial cells in vitro.

Evidence for direct effect of growth hormone on capillary basement membrane thickness.

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