Hypopigmented mycosis fungoides: a 20‐case retrospective series

Amorim, Gustavo Moreira; Niemeyer‐Corbellini, João Paulo; Quintella, Danielle Carvalho; Cuzzi, Tullia; Ramos‐e‐Silva, Márcia

doi:10.1111/ijd.13855

Cited by 25 publications

(40 citation statements)

References 29 publications

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“…Another reason is the higher prevalence of hypopigmented MF in South‐East Asians which has a predilection for younger people . It is known that hypopigmented MF occurs more commonly in patients of darker skin type, and this is corroborated in our study where it too was found with increased frequency in Indian patients. In our cohort, 21.8% (17/78 cases) of hypopigmented MF occurred in Indians and 54.8% (17/31 cases) of all MF diagnoses in Indians were hypopigmented MF (Tables and ).…”

Section: Discussionsupporting

confidence: 91%

Epidemiology and prognostic factors for mycosis fungoides and Sézary syndrome in a multi‐ethnic Asian cohort: a 12‐year review

Lim

Tan

Tee

et al. 2019

Acad Dermatol Venereol

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Background Limited information exists regarding survival of Asian patients with mycosis fungoides (MF) and Sézary syndrome (SS). Objective To evaluate the epidemiology, outcome and prognostic factors of these patients. Methods A retrospective review of MF/SS cases diagnosed from 2000 to 2011 at a tertiary referral dermatology centre in Singapore was performed. Results Of 246 patients, 63% were male and the median age at diagnosis was 49 years. 73.2% were Chinese, 12.6% Indian, 6.9% Malay and 7.3% Caucasian. A total of 239 patients (97.2%) had MF and seven had SS. Median follow‐up duration was 6.3 years, and median duration of symptoms at diagnosis was 13 months. For patients with MF, the majority had early disease (92.8% stage IA–IIA). 3.8% were stage IIB, 1.7% stage III and 1.7% stage IV. Complete response to treatment occurred in 78.2%, partial response in 9.6%, persistent but non‐progressive disease in 10.0% and disease progression in 4.1% of patients. Large cell transformation occurred in 4.1% of patients. Mean overall survival during this study was 12.7 years, with death occurring in 2.5% of patients (all ≥stage IIB at diagnosis). For patients with SS, 71.4% presented with stage IVA disease, 28.6% stage IVB. Complete response to treatment occurred in 14.2%, persistent but non‐progressive disease in 28.6% and disease progression in 57.2% of patients. Mean overall survival was 3.3 years within this study, with death occurring in 42.9% of SS patients. Prognostic factors associated with favourable recurrence‐free survival were male gender (P = 0.008), early disease stage (T1) at diagnosis (P < 0.001) and absence of maintenance treatment after remission (P = 0.01). Conclusion Compared to Caucasian and East Asian cohorts, MF in South‐East Asians was diagnosed at a younger age and associated with lower mortality, largely due to greater prevalence of hypopigmented MF.

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Section: Discussionsupporting

confidence: 91%

Epidemiology and prognostic factors for mycosis fungoides and Sézary syndrome in a multi‐ethnic Asian cohort: a 12‐year review

Lim

Tan

Tee

et al. 2019

Acad Dermatol Venereol

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“…It most commonly affects patients in childhood and adolescence. According to the recent study from Brazil24 , the average age of 20 hMF patients was 43.85 years. Rodney analyzed 20 hMF patients with an average age of 32.2 years 3 .…”

mentioning

confidence: 99%

Mycosis Fungoides and Variants of Mycosis Fungoides: A Retrospective Study of 93 Patients in a Chinese Population at a Single Center

Luo

Liu

et al. 2020

Ann Dermatol

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Background: Mycosis fungoides (MF) is the most common types of cutaneous T cell lymphoma. It typically presents with erythematous patches and plaques in the early stage and tumors and extracutaneous involvement with possibly fatal outcomes in the late stage. To facilitate early and accurate diagnosis of MF, it is essential to be knowledgeable of classic and variants of this disease. However, there is limited published data in the Chinese population. Objective: To characterize our patient group and to provide additional insight into these malignancies. Methods: Patients diagnosed with mycosis fungoides and its variants from October 2012 to January 2018 were retrospectively analyzed. Disease-specific survival (DSS) rate and curve according to early and advanced stages were also calculated. Results: The mean age at diagnosis of ninety-three MF patients was 38.9±1.73 years (range: 6∼77). Forty-five males (48.4%) and 48 females (51.6 %) were included in this study. The DSS rate of early-stage MF was 98.6%, while that of advanced stage MF was 88.9%. There was a significant difference in DSS rate between early stage and advanced stage MF (p=0.042, logrank test). The median age of 10 patients with hypopigmented MF (hMF) was 10.5 years (range: 6∼28). The age of hMF was younger than that of classical MF patients (p ＜0.05). Conclusion: Early-stage MF has a better prognosis than advanced stage and hMF affects younger people than classic MF among Chinese. This study provides an insight into mycosis fungoides and its variants in a Chinese population. (Ann Dermatol 32(1) 14∼20, 2020

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“…Lesions are occasionally accompanied by pruritus, sensitivity, telangiectasia, and/or atrophy. In rare cases, systemic signs, such as lymphadenopathy, are present [ 8 , 9 , 15 ]. In this review, we classified case reports/case series of HMF cases based on whether they took the Fitzpatrick skin phototype classification into account ( Supplementary Materials Table S1 ) or not ( Supplementary Materials Table S2 ).…”

Section: Characteristics Of Hypopigmented Mycosis Fungoidesmentioning

confidence: 99%

Hypopigmented Mycosis Fungoides: Loss of Pigmentation Reflects Antitumor Immune Response in Young Patients

Villarreal

Gantchev

Lagacé

et al. 2020

Cancers

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Hypopigmented mycosis fungoides (HMF) is a form of cutaneous T-cell lymphoma (CTCL), a heterogeneous group of extranodal non-Hodgkin’s lymphomas. HMF has a unique set of defining features that include light colored to achromic lesions, a predilection for darker skin phototypes, an early onset of disease, and predominance of CD8+ T-cells, among others. In the current review, we detail the known pathways of molecular pathogenesis for this lymphoma and posit that an active Th1/cytotoxic antitumor immune response in part explains why this variant is primarily seen in children/adolescents and young adults, who do not exhibit signs of immunosenescence. As a result of this potent cytotoxic response, HMF patients experience mostly favorable overall prognosis, while hypopigmentation may in fact represent a useful surrogate marker of cytotoxic immunity targeting the malignant cells. Understanding the molecular processes behind the specific features that define HMF may lead to improved diagnostic accuracy, personalized prognosis by risk stratification, and improved management of HMF. Moreover, improving our knowledge of HMF may aid our further understanding of other cutaneous lymphomas.

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Hypopigmented mycosis fungoides: a 20‐case retrospective series

Cited by 25 publications

References 29 publications

Epidemiology and prognostic factors for mycosis fungoides and Sézary syndrome in a multi‐ethnic Asian cohort: a 12‐year review

Epidemiology and prognostic factors for mycosis fungoides and Sézary syndrome in a multi‐ethnic Asian cohort: a 12‐year review

Mycosis Fungoides and Variants of Mycosis Fungoides: A Retrospective Study of 93 Patients in a Chinese Population at a Single Center

Hypopigmented Mycosis Fungoides: Loss of Pigmentation Reflects Antitumor Immune Response in Young Patients

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