Hypopigmented mycosis fungoides in Caucasian patients: A clinicopathologic study of 7 cases

Ardigò, Marco; Borroni, G.; Muscardin, Luca; Kerl, Helmut; Cerroni, Lorenzo

doi:10.1067/s0190-9622(03)00907-1

Cited by 99 publications

(125 citation statements)

References 40 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…A decrease or absence of melanocytes within lesions of hypopigmented mycosis fungoides, akin to melanocyte loss in vitiligo, has been noted leading to speculation on a cytotoxic effect of CD8 þ T cells on melanocytes. 1 In this context, hypopigmentation during flares of erythrodermic cutaneous T-cell lymphoma has been purported to result from reaction of cytotoxic T-cells. 12 On ultrastructural examination, damaged melanosomes 10 and a decreased number of melanosomes 11 have been observed in the lesional skin.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] The natural history of hypopigmented mycosis fungoides is similar to that of conventional mycosis fungoides, although the disease onset in hypopigmented cases is usually in childhood or adolescence; indeed, hypopigmented mycosis fungoides comprises 17% of all cases of mycosis fungoides in childhood. In contrast to conventional mycosis fungoides, in which the neoplastic cells are CD4 þ in the vast majority of cases, 5 the neoplastic cells in hypopigmented mycosis fungoides have a CD8 þ T-cell phenotype.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Decreased CD117 expression in hypopigmented mycosis fungoides correlates with hypomelanosis: lessons learned from vitiligo

et al. 2006

View full text Add to dashboard Cite

Hypopigmented mycosis fungoides is an uncommon clinical variant of cutaneous T-cell lymphoma. We hypothesized that hypomelanosis in hypopigmented mycosis fungoides may have a similar mechanism as in vitiligo, a condition in which it is believed that alterations in expression of CD117 (stem cell factor receptor/KIT protein) on epidermal melanocytes and abnormal interactions between melanocytes and surrounding keratinocytes may play a pathogenic role. To test the hypothesis that similar mechanisms might also explain hypopigmentation in hypopigmented mycosis fungoides, skin specimens from five cases each of hypopigmented mycosis fungoides and vitiligo were studied immunohistochemically for immunophenotype of the infiltrating cells, CD117 (expressed by epidermal melanocytes), and pan melanoma cocktail of antigens (gp100, tyrosinase, and MART-1) expression; cases of conventional mycosis fungoides and normal skin were studied in parallel as controls. Our findings confirm a predominance of CD8 þ neoplastic T cells in hypopigmented mycosis fungoides. Similarly, the epidermal lymphocytic infiltrate in vitiligo was also composed of CD8 þ cytotoxic T cells, in contrast to an epidermal infiltrate composed of CD4 þ T cells in conventional mycosis fungoides. The average number of epidermal CD117 expressing cells followed the same pattern of decreased expression in hypopigmented mycosis fungoides as in vitiligo, whereas the levels in conventional mycosis fungoides were higher, and similar to that observed in normal skin. Furthermore, a decreased number of melanocytes per high-power field of the length of the biopsy was present in hypopigmented mycosis fungoides and vitiligo, as compared with either conventional mycosis fungoides or normal skin, suggesting a correlation between decreased expression of CD117 and decreased number of melanocytes. We propose that decreased expression of CD117 and its downstream events in melanocytes may be initiated by cytotoxic effects of melanosomal-antigen-specific CD8 þ neoplastic T lymphocytes, resulting in destabilization of CD117 and leading to dysfunction and/or loss of melanocytes in the epidermis of hypopigmented mycosis fungoides.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Decreased CD117 expression in hypopigmented mycosis fungoides correlates with hypomelanosis: lessons learned from vitiligo

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Hipopigmente MF, klinik olarak daha çok gövde ve ekstremitelerin proksimali özellikle gluteal bölge gibi geniş alanlara dağılan, değişik çaplarda ve değişen derecelerde Hipopigmente lezyonlar MF'nin tek bulgusu olabileceği gibi eritemli yama, plak ve tümörlerle birlikte de görülebilir (6). Bu mikst klinik tip daha çok hastalığın nadir görüldüğü beyaz ırkta bildirilmiştir (1).…”

Section: Discussionunclassified

Hypopigmented Mycosis Fungoides: Case Report

Kurmuş¹,

Keseroglu²,

Gönül³

et al. 2018

tdd

View full text Add to dashboard Cite

Mikozis fungoides (MF) primer kutanöz T hücreli lenfomaların en sık görülen tipidir. Hipopigmente MF nadir görülen atipik bir klinik varyant olup daha çok Afrika, Hindistan, Latin Amerika ve Asya kökenli koyu tenli bireylerde, özellikle çocuk ve genç erişkinlerde görülmektedir. Beyaz ırkta çok nadir görülmekle birlikte hastalar genellikle gövde ve proksimal ekstremitelere dağılan asemptomatik, düzensiz sınırlı, skuamsız hipopigmente yamalar ile başvurmaktadırlar. Gövde ve üst ekstremitelere dağılan yaygın beyaz lekeler şikayeti ile başvuran, klinik ve histopatolojik olarak hipopigmente MF tanısı konan yirmi beş yaşında kadın olgu nadir görülmesi nedeniyle sunulmuştur. Öz AbstractMycosis fungoides (MF) is the most common type of primary cutaneous T-cell lymphoma. Hypopigmented MF is a rare atypical clinical variant and is mostly seen in dark-skinned individuals of Africa, India, Latin America and Asian origin, especially in children and young adults. As well as it is seen very rare in Caucasians, patients usually consult with asymptomatic, irregular, non-squamous hypopigmented patches which distributed in the trunk and proximal extremities. A 25-year-old female patient clinically and histopathologically hypopigmented MF who presented with diffuse white stains on the trunk and upper extremities was presented because of its rarity.

show abstract

“…Apart from the classic Alibert-Bazin type, MF has many clinical and histologic subtypes, viz verrucous, vesicular, pustular, granulomatous, poikilodermatous, ichthyosiform and hypopigmented [10]. Though MF is primarily a disease of adults/elderly and comparatively rare in Asians, the hypopigmented variant is commoner in children and in dark skinned Asians vis-à-vis Caucasians [11]. The predominant location on the buttocks and other unexposed body areas is an important feature and clue to the diagnosis [1].…”

Section: Discussionmentioning

confidence: 99%