Hypoplasia of the inferior vena cava in a young man presenting with extensive deep venous thrombosis

Alderman, Bryony Eloise Pfyffer; Boisanger, James de; Bottomley, Thomas

doi:10.1136/bcr-2015-211849

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…PCDT, compared to systemic anticoagulation alone, significantly decreases the thrombus burden and incidence of recurrent DVT in patients with extensive iliofemoral DVT [ 18 ]. PCDT could be a treatment option in patients with symptomatic iliofemoral DVT, good functional status, life expectancy of 1 year or more, and low risk of bleeding [ 19 ]. However, studies focusing on the long-term outcomes following PPCDT are desperately needed as evidence is lacking.…”

Section: Discussionmentioning

confidence: 99%

The Typical Presentation Spectrum of Deep Vein Thrombosis Associated with Inferior Vena Cava Malformations

et al. 2016

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Congenital malformations of the inferior vena cava (IVC) are rare and underreported. They can be a risk factor for deep venous thrombosis (DVT) as a result of inadequate venous drainage of the lower extremities through collateral circulation. The significant number of cases reported in the literature highlights their importance, warranting investigating their existence in younger individuals with idiopathic DVT of the lower extremities and pelvic veins. In this systematic review, we depict the typical presentation of IVC malformations, their management, and the management of their associated DVT.

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Section: Discussionmentioning

confidence: 99%

The Typical Presentation Spectrum of Deep Vein Thrombosis Associated with Inferior Vena Cava Malformations

et al. 2016

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“…Following the detachment of thrombi, patients may experience pulmonary embolism and respiratory distress (5,6). Furthermore, DVT may progress to post-thrombotic syndrome, which seriously affects patient quality of life and may cause pain (7).…”

Section: Introductionmentioning

confidence: 99%

Role of microRNA‑26a in the diagnosis of lower extremity deep vein thrombosis in patients with bone trauma

2017

Exp Ther Med

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Abstract. The present study aimed to investigate the role and mechanism of action of microRNA (miR)-26a in deep vein thrombosis (DVT). Peripheral blood was collected from 45 patients with DVT and 40 healthy controls. Levels of miR-26a, chemokine C-C motif ligand (CCL)2 mRNA and CCL7 mRNA were detected using reverse transcription-quantitative polymerase chain reaction and the value of miR-26a in the clinical diagnosis of DVT was assessed using receiver operating characteristic curve analysis. The correlation of miR-26a with CCL2 and CCL7 levels was analyzed using Spearman's rank correlation. In addition, miR-26a and protein kinase C δ (PRKCD) were overexpressed in human umbilical vein endothelial cells (HUVECs) and PRKCD expression was knocked down by small interfering (si)RNA. Western blotting was conducted to detect the expression of PRKCD and p65. Furthermore, a dual-luciferase reporter gene assay was performed. The results of the current study demonstrated that the expression of miR-26a was significantly downregulated in the peripheral blood of patients with DVT compared with healthy controls (P<0.05) and negatively correlated with CCL2 and CCL7 levels (P<0.05). Furthermore, it was demonstrated that miR-26a markedly inhibited the expression of PRKCD, significantly decreased levels of CCL2 and CCL7 mRNA (P<0.05) and inhibited activation of the NF-κB signaling pathway. Overexpression of PRKCD in HUVECs inhibited the effects of miR-26a and markedly upregulated the phosphorylation of p65. The present study indicated that miR-26a directly targets PRKCD mRNA and that miR-26a may be a useful biomarker in the clinical diagnosis of DVT. Thus, the present findings suggest that miR-26a regulates the NF-κB signaling pathway by binding to PRKCD mRNA, inhibits the expression of CCL2 and CCL7 and reduces the risk of DVT.

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Conservative treatment vs thrombus removal for Iliofemoral vein thrombosis in patients with congenital abnormalities of the inferior vena cava: a case report and systematic review of the literature

Alexiou

Ntanika

Pappas

et al. 2022

J Thromb Thrombolysis

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Hypoplasia of the inferior vena cava in a young man presenting with extensive deep venous thrombosis

Cited by 4 publications

References 9 publications

The Typical Presentation Spectrum of Deep Vein Thrombosis Associated with Inferior Vena Cava Malformations

The Typical Presentation Spectrum of Deep Vein Thrombosis Associated with Inferior Vena Cava Malformations

Role of microRNA‑26a in the diagnosis of lower extremity deep vein thrombosis in patients with bone trauma

Conservative treatment vs thrombus removal for Iliofemoral vein thrombosis in patients with congenital abnormalities of the inferior vena cava: a case report and systematic review of the literature

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