Hypoprolactinemia as Related to Seminal Quality and Serum Testosterone

Gonzales, Gustavo F.; Velásquez, Guzmán; García-Hjarles, Marco Antonio

doi:10.3109/01485018908986849

Cited by 32 publications

(17 citation statements)

References 23 publications

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“…Men with hypoprolactinemia have low sperm motility and hyperviscosity of the semen samples [5]. Since prolactin is a product of secretion of the seminal vesicles [ 151, and its seminal level is reduced by hypofunction of the seminal vesicles [4], then it is feasible that hyperviscosity may be associated to hypofunction of the seminal vesicles, as it has been demonstrated in the present study.…”

Section: Discussionmentioning

confidence: 78%

Hyperviscosity and Hypofunction of the Seminal Vesicles

Gonzales

Kortebani

Mazzolli

1993

Archives of Andrology

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The study was designed to determine whether hyperviscosity of the semen sample is related to dysfunction of the male accessory glands. It was carried out on men who consecutively attended an infertility clinic between June 1989 and June 1991, and the men were grouped according to viscosity of semen samples (normal viscosity or higher viscosity). Semen samples from 229 infertility patients were studied. From these, 155 had normal viscosity and 74 showed hyperviscosity. The effect of hyperviscosity of semen samples on seminal quality and the function of the prostate was evaluated by acid phosphatase measurement, and the seminal vesicles by measurement of corrected fructose. Sperm motility (grades II-III), sperm vitality, and corrected fructose were significantly reduced in samples with high viscosity (p < .05). A high prevalence of hyperviscosity in semen samples was associated with only hypofunction of the seminal vesicles. In fact, 36.5% of subjects with hyperviscosity showed reduced levels of corrected fructose. The same association with hyperviscosity was not observed when only hypofunction of the prostate was present, or when hypofunction of both prostate and seminal vesicles was present (P:NS). Further analysis showed that high viscosity is observed mainly when corrected seminal fructose levels were below 1.5 mg/mL x 10(6) spz/mL. It would appear that hyperviscosity affects sperm motility and is associated with hypofunction of the seminal vesicles.

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Section: Discussionmentioning

confidence: 78%

Hyperviscosity and Hypofunction of the Seminal Vesicles

Gonzales

Kortebani

Mazzolli

1993

Archives of Andrology

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“…This is thought to be mediated by the suppression of testosterone secretion (Suescun et al 1985;Gonzales et al 1989). Interestingly, this effect may be reversed, at least partially, by the administration of a dopamine antagonist (Ufearo and Orisakwe 1995).…”

Section: Introductionmentioning

confidence: 99%

Prolactin Serum Concentrations During Aripiprazole Treatment in Youth

Safer

Calarge

Safer

2013

Journal of Child and Adolescent Psychopharmacology

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Objective: This study aimed to: document the extent of the reduction of serum prolactin (PRL) levels induced by aripiprazole (ARI) treatment in children and adolescents, compare this effect by age group, and shed light on this phenomenon. Methods: PRL serum levels in unmedicated subjects were compared to those in subjects treated with aripiprazole to calculate the rate of subnormal PRL levels during aripiprazole treatment. Next, a literature search was performed to better understand the effects of dopaminergic drugs on PRL levels by age group. Results: Sixty percent of those treated with aripiprazole exhibited subnormal PRL serum levels versus 8% of unmedicated subjects. The rate of PRL subnormality in response to aripiprazole was half as frequent in adolescents and was minimal in adults. The drug-induced reduction of PRL serum levels became more prominent with increasing doses of aripiprazole and with an increased treatment duration. Conclusions: With the increasing use of aripiprazole in the United States population, it is important that future research be conducted to explore the potential sequelae of subnormal PRL serum levels in children and adolescents.

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“…Hypoprolactinemia induced by high doses of PFOS could have a very important pathophysiological significance because of the multiple functions exerted by prolactin (Fitzgerald and Dinan, 2008). Low serum prolactin levels are associated mainly with several reproductive diseases (Fitzgerald and Dinan, 2008;Egli et al, 2010) such as a low seminal quality, poor sperm motility and different testicular disorders like oligozoospermia, asthenospermia, hypofunction of seminal vesicles and hypoandrogenism (Gonzales et al, 1989). Moreover, hypoprolactinemia reduces basal testosterone secretion and its response to hCG stimulation (Oseko et al, 1991).…”

Section: Discussionmentioning

confidence: 98%