Hypoprothrombinemia in patients with cancer receiving cefoperazone and mezlocillin

Jones, Paula G.; Strother, S. Vance; Rolston, Kenneth V. I.; Fainstein, Victor; Bodey, Gerald P.

doi:10.1001/archinte.146.7.1397

Archives of Internal Medicine

1986

DOI: 10.1001/archinte.146.7.1397

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Hypoprothrombinemia in patients with cancer receiving cefoperazone and mezlocillin

Paula G. Jones

S. Vance Strother

Kenneth V. I. Rolston³

et al.

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1987

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Cited by 5 publications

References 16 publications

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Coagulopathy Caused by Vitamin K Deficiency in Critically III, Hospitalized Patients

Alperin¹

1987

JAMA

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A coagulopathy due to vitamin K deficiency was discovered in 42 hospitalized patients, most of whom had been misdiagnosed as having disseminated intravascular coagulation. Factors contributing to vitamin deficiency included inadequate diet, malabsorption, failure of physicians to prescribe vitamin K supplements, antibiotic therapy, renal insufficiency, hepatic dysfunction, recent major surgery, and possibly pregnancy. Sixteen patients (34%) bled sufficiently to need red blood cell transfusions and ten patients (24%) ultimately died. Of 18 patients who also had thrombocytopenia, three did have disseminated intravascular coagulation. The deficiency, a contributor to morbidity and mortality, can be prevented by prophylactic administration of vitamin K to severely ill patients who are eating inadequately and receiving antibiotics.

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Coagulopathy Caused by Vitamin K Deficiency in Critically III, Hospitalized Patients

Alperin¹

1987

JAMA

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Single agent therapy for infections in cancer patients: A prospective randomized trial comparing three extended-spectrum cephalosporins

Rolston

Jones

Fainstein

et al. 1991

Eur. J. Clin. Microbiol. Infect. Dis.

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Three hundred and twenty patients were enrolled in a prospective randomized trial comparing cefoperazone, ceftizoxime and ceftriaxone for initial therapy of infectious episodes in cancer patients. Patients with neutropenia were excluded. In 286 evaluable episodes, the response rates associated with the three agents were 77% for cefoperazone, 70% for ceftizoxime and 72% for ceftriaxone, with no statistically significant differences between the three treatment groups. The overall response rate for all episodes of pneumonia (64%) was significantly lower than the response rate for all other infections (81%; p = 0.002), and the mortality associated with pneumonia (9%) was higher than that associated with all other episodes (2%; p = 0.01). Patients with infections due to gram-negative organisms responded well to all three agents, whereas patients with gram-positive infections responded more favorably to cefoperazone. Two different schedules of ceftriaxone were used. The clinical response did not differ significantly between patients receiving ceftriaxone once daily and those receiving it twice daily. The incidence of superinfection and relapse was extremely low and all three agents were well tolerated. It is concluded that extended spectrum cephalosporins are effective as single agents for the treatment of infections in cancer patients with adequate neutrophil counts.

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Cefoperazone/Sulbactam-Induced Abdominal Wall Hematoma and Upper Gastrointestinal Bleeding: A Case Report and Review of the Literature

Cai

Yang

et al. 2016

Drug Saf - Case Rep

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An 87-year-old woman developed abdominal wall hematoma and upper gastrointestinal bleeding during treatment with cefoperazone/sulbactam for pneumonia. The woman received cefoperazone/sulbactam at 4.5 g twice daily for intravenous infusion. After 7 days, she developed sudden onset of left lower abdominal pain, associated with subcutaneous mass, and vomited a coffee-colored liquid. Investigations revealed a coagulation index abnormality and activated partial thromboplastin time and prothrombin time increased obviously. She was diagnosed with cefoperazone-induced hemorrhage. Cefoperazone/sulbactam was discontinued and the patient received vitamin K1. The blood coagulation function improved and hematoma disappeared after 3 days. A Naranjo assessment score of 6 was obtained, indicating a probable relationship between the patient’s coagulation function disorder and her use of the suspect drug.

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Hypoprothrombinemia in patients with cancer receiving cefoperazone and mezlocillin

Cited by 5 publications

References 16 publications

Coagulopathy Caused by Vitamin K Deficiency in Critically III, Hospitalized Patients

Coagulopathy Caused by Vitamin K Deficiency in Critically III, Hospitalized Patients

Single agent therapy for infections in cancer patients: A prospective randomized trial comparing three extended-spectrum cephalosporins

Cefoperazone/Sulbactam-Induced Abdominal Wall Hematoma and Upper Gastrointestinal Bleeding: A Case Report and Review of the Literature

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