Hypotensive 1,2,4-Benzothiadiazines

Abstract

3,4-dimethyl-5-phenyloxazolidine (X).41-A 7.0 g. sample (0.0425 mole) of tff-ephedrine30 was cyclized with cyanogen bromide using Method A. After recrystallization from etherpetroleum ether, 4.77 g. (50.5%) of pure 2-imino-3,4-dimethyl-5phenvl-2-oxazolidine (X) was obtained, m.p. 67-71 °. Literature41' m.p.'71-73°: )£% 3

First Generation Light-Harvesting Dendrimers with a [Ru(bpy)3]2+ Core and Aryl Ether Ligands Functionalized with Coumarin 450

“…3,5-Bis(N-(4,6-dimethyl-7-ethylaminocoumarin)methyl)phenol, 5, was synthesized as described. [10] Commercially available [Ru-(bpy) 3 ]Cl 2´6 H 2 O (Aldrich) was converted into the corresponding PF 6 À salt by metathesis with NH 4 PF 6 (Aldrich) in water. Reversed-phase HPLC (C18, semi-preparative) was performed with a Waters HPLC system equipped with a diode array absorption detector.…”

“…WILEY states are especially intriguing because of their outstanding photochemical, photophysical, and electrochemical properties. [6] In this regard, many large polynuclear dendritic arrays of MLCT complexes have been synthesized and their photophysical and electrochemical properties generally display novel characteristics. [7] Very recently, it has been reported that a single [Ru(bpy) 3 ] 2 core (bpy 2,2'-bipyridine) can be tethered to a well defined array of benzyl, 4'-tert-butylphenyloxy, or naphthyl peripheral units.…”

“…The long lifetimes associated with these new structures permit bimolecular solution chemistry commonly associated with [Ru(bpy) 3 ] 2 , such as electron transfer reactions. [6,9] The current approach could potentially be extended to other donor ± acceptor organic ± inorganic pairs to harvest visible light and exhibit sensitized long lifetime emission in the red to near IR range.…”

Thin-layer Chromatography of Cardiac Glycosides

“…Zinc-Sodium Hydroxide Method (6).--In this method thc organic iodine is replaced with hydrogen generated iii the nascent form by the reaction of zinc and sodium hydroxide.…”

Saccharin Derivatives VIII. Hypotensive Agents

“…Cer-tain of them also show hypotensive activity and are used clinically in the treatment of mild hypertension (2). Several recent papers describe closely related substatices lacking the sulfamoyl group, exemplified by 7-chloro-3-methyl-1,2,4-benzothiadiazine 1,ldioxide (diazoxide) (11), as possessing antihypertensive but not diuretic activity (3)(4)(5)(6).…”