Hypotensive activity of ovatodiolides isolated from a Chinese crude drug ‘Fáng Féng Cáo’

Abstract

antagonistic effect on Ca2+ current. These results suggest that the hypotensive activity by ovatodiolides at least, partly, may be due to inhibition of myocardial contraction.

Bioactive Cembrane Diterpenoids of Anisomeles indica

“…In previous studies, many chemical constituents were identified from this plant, including terpenoids, [3][4][5][6][7][8][9] flavonoids, 6,10-13 steroids, 7 and some miscellaneous substances. 5,7 Of these, ovatodiolide (7), the major component of A. indica, 8,9 belonging to the cembrane class of diterpenoids, has exhibited several biological activities, such as cytotoxicity 8,9 and antihypertensive 14 and anti-HIV effects. 15 In addition, an ethanolic extract of A. indica showed an inhibitory effect on the growth of Helicobacter pylori.…”

“…According to the Dictionary of Chinese Crude Drugs “Zhong-yao-da-ci-dian”, the dried whole plant of A. indica has been used for the treatment of gastrointestinal disease and hypertension in mainland China. In previous studies, many chemical constituents were identified from this plant, including terpenoids, – flavonoids, ,– steroids, and some miscellaneous substances. , Of these, ovatodiolide ( 7 ), the major component of A. indica, , belonging to the cembrane class of diterpenoids, has exhibited several biological activities, such as cytotoxicity , and antihypertensive and anti-HIV effects . In addition, an ethanolic extract of A. indica showed an inhibitory effect on the growth of Helicobacter pylori…”

Ovatodiolide Targetsβ-Catenin Signaling in Suppressing Tumorigenesis and Overcoming Drug Resistance in Renal Cell Carcinoma

“…Ovatodiolide is a cemsbrane-type diterpenoid and one of the major components of A. indica L. It can reduce lipopolysaccharide-induced nitric oxide and cytokine levels in macrophages [44] and blood pressure in anaesthetized dogs [45] and is responsible for the anti-inflammatory and antihypotensive effects of A. indica . Ovatodiolide also has cytotoxic effects in some human cancer cell lines by inducing apoptotic pathways [46, 47] and has antimetastatic effects by downregulating c-Jun N-terminal kinase, p38 mitogen-activated protein kinase, and PI3K/AKT signaling pathways, therefore inhibiting NF κ B-MMP-9 axis activation [48].…”

The natural diterpenoid ovatodiolide induces cell cycle arrest and apoptosis in human oral squamous cell carcinoma Ca9-22 cells

“…This plant has been traditionally used for treatment of gastric dysfunction, inflammatory disorders, and hypertension in China and India (Arisawa et al 1986a). It has been reported that ovatodiolide prevented LPS-stimulated NO and cytokines in macrophages (Rao et al 2009) and decreased the blood pressure in anaesthetized dogs (Momose et al 1994), indicating that ovatodiolide is responsible for the anti-inflammatory and hypotensive effects of A. indica. In addition, ovatodiolide was shown to display cytotoxicity against the OSCC cell line KB (Arisawa et al 1986b).…”