Hypotensive and Bradycardic Effects of Quinovic Acid Glycosides <i>from Aspidosperma fendleri</i> in Spontaneously Hypertensive Rats

Estrada, Omar; González-Guzmán, Juan M.; Salazar-Bookman, María M.; Cardozo, Alfonso; Lucena, Eva; Alvarado-Castillo, Claudia

doi:10.1177/1934578x1501000216

Cited by 5 publications

(6 citation statements)

References 21 publications

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“…In the present study, Aspidocarpine showed a similar antihypertensive response, but in lower concentrations. In addition, extracts of A. subincanum [ 15 ], A. pyrifolium [ 14 ], A. fendleri [ 13 ], and A. macrocarpum [ 12 ] showed significant hypotensive effects, consistent with the results presented by Aspidocarpine. These reports confirm that the genus Aspidosperma is an important source of alkaloids with cardiovascular activity.…”

Section: Resultssupporting

confidence: 74%

“…Many of this species are used in folk medicine for the treatment of malaria [ 8 ], fever [ 9 ], inflammation, diabetes, high blood pressure [ 10 ], and cardiovascular diseases [ 11 ]. In addition, studies carried out with extracts from several species of Aspidosperma showed important antihypertensive effects [ 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats

Monteiro

Nogueira

et al. 2022

Molecules

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The alkaloid Aspidocarpine was isolated from the bark of Aspidosperma desmanthum. Its structure was elucidated by the spectral data of 1H and 13C-NMR (1D and 2D) and high-resolution mass spectrometry (HRESIMS). The antihypertensive activity was investigated by intravenous infusion in Wistar rats. This alkaloid significantly reduced (p < 0.05) the systolic, median, and diastolic blood pressures of rodents, without causing motor incoordination and imbalance in the rotarod test. The results indicate that the alkaloid Aspidocarpine exerts its antihypertensive activity without causing sedation or the impairment of motor functions.

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Section: Resultssupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats

Monteiro

Nogueira

et al. 2022

Molecules

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“…quinovic acid 3-O-β-rhamnopyranoside (9) and quinovic acid 3-O-βfucopyranoside (10) were isolated. These saponins showed hypotensive and bradycardic activity (Estrada et al, 2015). The species Aspidosperma subincanum and Aspidosperma tomentosum are used by the population in Brazil to treat diseases.…”

Section: -Introductionmentioning

confidence: 99%

Aspidosperma species: A review of their chemistry and biological activities

Almeida

Silva

et al. 2019

Journal of Ethnopharmacology

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Ethnopharmacological relevanceSpecies of Aspidosperma are known popularly as "peroba, guatambu, carapanaúba, pau-pereiro" and "quina". The genus can be found in the Americas, mainly between Mexico and Argentina. Many species of Aspidosperma are used by the population in treating cardiovascular diseases, malaria, fever, diabetes and rheumatism. The phytochemical aspects of the species of the genus Aspidosperma have been studied extensively. The monoterpene indole alkaloids are the main secondary metabolites in Aspidosperma species, and about 250 of them have been isolated showing a considerable structural diversity. Several of them have showed some important pharmacological activities. Aspidosperma subincanum Mart. and Aspidosperma tomentosum Mart. (Apocynaceae) are Brazilian species widely used by the population to treat diabetes mellitus, hypercholesterolemia. The pharmacological activities of both species have been investigated and the biological properties described can be related to their isolated indole alkaloids. However, more pharmacological studies are needed in order to justify the use of these species in folk medicine. In this review, we present reports mainly focused on chemical and biological studies and their relationship with the ethnopharmacological use of both Aspidosperma species. Aim of the studyThe aim of this review is to present their ethnopharmacological use as correlated to their biological activities as described for the extracts and isolated compounds from Aspidosperma subincanum Mart. and Aspidosperma tomentosum Mart. In addition, some aspects related to the biosynthetic pathways are discussed, also NMR assignments and some synthesis information about indole alkaloids from both Aspidosperma species are included. Material and methodsThe bibliographic search was made in theses and dissertations using some databases such as NDLTD (Networked Digital Library of Theses and Dissertations), OATD (Open Access Theses and Dissertations) and 3 Google Scholar. More data were gathered from books, Brazilian journals and articles available on electronic databases such as, Google Scholar, PubChem, Scifinder, Web of Science, SciELO, PubMed and Science Direct.Additionally, the Google Patents and Espacenet Patent Search (EPO) were also consulted. The keywords Aspidosperma, Aspidosperma subincanum, Aspidosperma tomentosum, indole alkaloids were used in the research. The languages were restricted to Portuguese, English and Spanish and references were selected according to their relevance. Results Aspidosperma subincanumMart. and Aspidosperma tomentosum Mart. (Apocynaceae) are Brazilian species widely used by the population to treat a few diseases. Extracts and isolated compounds of both species have shown antitumor and antimalarial activities.The antitumor activity of isolated compounds has been extensively studied. However, the antiplasmodial activity needs to be investigated further as well as the antiflamatory, anti-hyperlipidemic and anorexigenic activities. From A. subincanum twenty-one indole alkaloids ...

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“…The genus Aspidosperma is a source of biologically active indole alkaloids (Pereira et al, ) even though other classes of secondary metabolites have been reported (Estrada et al, ). The species A. subincanum Mart.…”

Section: Resultsmentioning

confidence: 99%

Biological activities of extracts from Aspidosperma subincanum Mart. and in silico prediction for inhibition of acetylcholinesterase

Rocha

Campana

Scoaris

et al. 2018

Phytotherapy Research

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Species of Aspidosperma are traditionally used to treat malaria, leishmaniasis, microbial, and inflammatory diseases. Aspidosperma subincanum Mart. known as "guatambu" is used in Brazilian traditional medicine to treat diabetes, hypercholesterolemia, and digestive diseases. Its tonic properties have been employed by the indigenous populations to stimulate the circulatory and genitourinary tracts and to improve respiratory function as well as to relieve spasms and to reduce fever. The species is known to contain antitumoural and antimalarial indole alkaloids. In the present study, various less explored biological activities of extracts from leaves and branches of A. subincanum were investigated, that is, inhibition of acetylcholinesterase as well as antioxidant and antibacterial activity. Twenty-one known indole alkaloids from this species were targeted for predicting the inhibition of acetylcholinesterase, and their biological activities were collected from the literature. Through in silico the prediction, the indole alkaloids uleine and derivatives demonstrated a strong probability of being able to inhibit the acetylcholinesterase enzyme, as well as the olivacine derivatives 3,4-dihydroolivacine and N-methyl-tetrahydro-olivacine (guatambuine), and the subincanadines C and E. Indeed, the extracts of A. subincanum showed acetylcholinesterase inhibitory activity, antioxidant activity in the lipid peroxidation assay, and antimicrobial activity against Staphylococcus aureus ATCC 25923, and their pharmacological properties should be explored further.

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Hypotensive and Bradycardic Effects of Quinovic Acid Glycosides from Aspidosperma fendleri in Spontaneously Hypertensive Rats

Cited by 5 publications

References 21 publications

Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats

Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats

Aspidosperma species: A review of their chemistry and biological activities

Biological activities of extracts from Aspidosperma subincanum Mart. and in silico prediction for inhibition of acetylcholinesterase

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