Hypotensive and vasorelaxant effects of the procyanidin fraction from Guazuma ulmifolia bark in normotensive and hypertensive rats

Antihypertensive and Vasorelaxant Effects of Water-Soluble Proanthocyanidins from Persimmon Leaf Tea in Spontaneously Hypertensive Rats

“…9,10) PAs are structurally diverse flavanol polymers present in a wide variety of dietary products. In fact, cacao, 11) apple, 12) and grape seeds 13) have all been found to contain PAs with endothelium-dependent vasorelaxant activity and the ability to lower blood pressure.…”

Medicinal Plants that can Cause Changes in Blood Pressure and Interactions with Antihypertensive Agents

“…However, fructosans, through their diuretic effect, may act as adjuvants [20][21][22][23][24]. Oligomeric flavonoids, as procyanidins, present in plants such as Crataegus laevigata, exert vasodilatory effect with consequent reduction in blood pressure [25,26]. Crataegus laevigata also has its hypotensive activity justified by the presence of amines in their fresh flowers, as tyramine [20] and by angiotensin converting enzyme inhibition [27].…”

Modulation of adipogenesis-related gene expression by ethanol extracts of Detam 1 soybean and Jati belanda leaf in 3T3-L1 cells

“…Several soy isoflavonesin from soybean revealed to inhibit adipogenesis through down -regulation of adiponectin expression in 3T3-L1 adipocytes (Zhang et al, 2009;Yanagisawa et al, 2012). Guazuma ulmifolia Lam., known as "Jati belanda" in Indonesia has been popularly used as therapeutics for hypercholesterolemic, gastro-intestinal disorder, diabetes mellitus, and to reduce weight in some parts of the world (Feltrin et al, 2012;Magos et al, 2008). Our previous study demonstrated that ethanol extract of Detam 1 soybean seeds and ethanol extract of Jati belanda leaves have potential as anti-obesity, it inhibited weight gain in male Wistar rat and possessed inhibitory activities toward glucose-6-phosphate dehydrogenase (G6PD), triglyceride (TG) and cholesterol (CHOL) in 3T3-L1 cell line (Hidayat et al, 2015a;Hidayat et al, 2015b).…”