Hypotensive drugs

Tester-Dalderup, C.B.M.

doi:10.1016/s0378-6080(79)80024-0

Side Effects of Drugs Annual

1979

DOI: 10.1016/s0378-6080(79)80024-0

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Hypotensive drugs

C.B.M. Tester-Dalderup¹

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1989

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Delayed postoperative neurological deterioration from prolonged sodium nitroprusside administration

Ram¹,

Spiegelman²,

Findler³

et al. 1989

Journal of Neurosurgery

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Sodium nitroprusside is commonly used for the induction of hypotension during neurosurgical procedures. Its toxicity stems from hemodynamic compromise as well as from its metabolites, especially the formation of cyanide. A patient is described who underwent craniotomy for hypertensive intracerebral hemorrhage. He gradually recovered following the operation, but needed continued administration of sodium nitroprusside for control of hypertension. On the 7th postoperative day, he deteriorated into coma with evidence of severe edema and herniation on the computerized tomography scan. Cessation of sodium nitroprusside and treatment for cyanide poisoning resulted in resolution of his symptoms within hours. The potential toxicity of sodium nitroprusside, measures to prevent toxicity, and therapeutic steps are discussed.

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Delayed postoperative neurological deterioration from prolonged sodium nitroprusside administration

Ram¹,

Spiegelman²,

Findler³

et al. 1989

Journal of Neurosurgery

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show abstract

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Hypotensive drugs

Cited by 1 publication

References 63 publications

Delayed postoperative neurological deterioration from prolonged sodium nitroprusside administration

Delayed postoperative neurological deterioration from prolonged sodium nitroprusside administration

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