Hypotensive effect of crude extract &lt;i&gt;Olea. africana (Oleaceae)&lt;/i&gt; in normo and hypertensive rats

Osim, E. E.; Mbajiorgu, E F; Mukarati, G; Vaz, Raquel Ferreira; Makufa, B; Munjeri, O.; Musabayane, C T

doi:10.4314/cajm.v45i10.8498

Cited by 2 publications

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“…Animal studies demonstrated that the aqueous and ethanolic olive leaves extract (OLE) given to hypertensive rats at dosages ranging from 100 to 1000 mg/kg for 2-6 weeks significantly lowered mean arterial pressure and heart rate (Osim et al, 1999;Khayyal et al, 2002). Another animal study showed methanolic OLE (consists oleuropein) given to salt-sensitive, genetically hypertensive rats at 60 mg/kg body weight for 6 weeks prevented the development of severe hypertension and atherosclerosis and improved insulin resistance (Somova et al, 2003).…”

Section: Anti-hypertensive Effectmentioning

confidence: 97%

Cardioprotective and neuroprotective roles of oleuropein in olive

Omar

2010

Saudi Pharmaceutical Journal

123

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Traditional diets of people living in the Mediterranean basin are, among other components, very rich in extra-virgin olive oil, the most typical source of visible fat. Olive is a priceless source of monounsaturated and di-unsaturated fatty acids, polyphenolic antioxidants and vitamins. Oleuropein is the main glycoside in olives and is responsible for the bitter taste of immature and unprocessed olives. Chemically, oleuropein is the ester of elenolic acid and 3,4-dihydroxyphenyl ethanol, which possesses beneficial effects on human health, such as antioxidant, antiatherogenic, anti-cancer, anti-inflammatory and antimicrobial properties. The phenolic fraction extracted from the leaves of the olive tree, which contains significant amounts of oleuropein, prevents lipoprotein oxidation. In addition, oleuropein has shown cardioprotective effect against acute adriamycin cardiotoxicity and an anti-ischemic and hypolipidemic activities. Recently, oleuropein has shown neuroprotection by forming a non-covalent complex with the Aβ peptide, which is a key hallmark of several degenerative diseases like Alzheimer and Parkinson. Thus, a large mass of research has been accumulating in the area of olive oil, in the attempt to provide evidence for the health benefits of olive oil consumption and to scientifically support the widespread adoption of traditional Mediterranean diet as a model of healthy eating. These results provide a molecular basis for some of the benefits potentially coming from oleuropein consumption and pave the way to further studies on the possible pharmacological use of oleuropein to prevent or to slow down the cardiovascular and neurodegenerative diseases.

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Section: Anti-hypertensive Effectmentioning

confidence: 97%

Cardioprotective and neuroprotective roles of oleuropein in olive

Omar

2010

Saudi Pharmaceutical Journal

123

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“…Several plant extracts with potential therapeutic properties for the treatment of hypertension and complications such as coronary heart disease, angina, arrhythmias and congestive heart failure have been identified 33-36. Traditional medicinal healers in southern Africa have used Helichrysum ceres S Moore [Asteraceae] to treat kidney and cardio-respiratory disorders 37.…”

Section: Natural Plants For Cardiovascular Diseasementioning

confidence: 99%

The effects of medicinal plants on renal function and blood pressure in diabetes mellitus : review article

Musabayane¹

2012

CVJA

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Diabetes mellitus is one of the most common chronic global diseases affecting children and adolescents in both the developed and developing nations. The major types of diabetes mellitus are type 1 and type 2, the former arising from inadequate production of insulin due to pancreatic β-cell dysfunction, and the latter from reduced sensitivity to insulin in the target tissues and/or inadequate insulin secretion. Sustained hyperglycaemia is a common result of uncontrolled diabetes and, over time, can damage the heart, eyes, kidneys and nerves, mainly through deteriorating blood vessels supplying the organs. Microvascular (retinopathy and nephropathy) and macrovascular (atherosclerotic) disorders are the leading causes of morbidity and mortality in diabetic patients. Therefore, emphasis on diabetes care and management is on optimal blood glucose control to avert these adverse outcomes.Studies have demonstrated that diabetic nephropathy is associated with increased cardiovascular mortality. In general, about one in three patients with diabetes develops end-stage renal disease (ESRD) which proceeds to diabetic nephropathy (DN), the principal cause of significant morbidity and mortality in diabetes. Hypertension, a well-established major risk factor for cardiovascular disease contributes to ESRD in diabetes. Clinical evidence suggests that there is no effective treatment for diabetic nephropathy and prevention of the progression of diabetic nephropathy. However, biomedical evidence indicates that some plant extracts have beneficial effects on certain processes associated with reduced renal function in diabetes mellitus. On the other hand, other plant extracts may be hazardous in diabetes, as reports indicate impairment of renal function. This article outlines therapeutic and pharmacological evidence supporting the potential of some medicinal plants to control or compensate for diabetes-associated complications, with particular emphasis on kidney function and hypertension.

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Hypotensive effect of crude extract <i>Olea. africana (Oleaceae)</i> in normo and hypertensive rats

Cited by 2 publications

References 0 publications

Cardioprotective and neuroprotective roles of oleuropein in olive

Cardioprotective and neuroprotective roles of oleuropein in olive

The effects of medicinal plants on renal function and blood pressure in diabetes mellitus : review article

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