Hypoth�ses sur la g�n�tique formelle du syst�me Gm chez les caucasiens

The Influence of the Anti-Rh Coat and Red Cells on the Manifestation of the Gm(b) Phenotype

“…Though such anomalies are excessively rare among Caucasians, it is common among certain yellow-skinned peoples, particularly the Japanese and the American Indians, in whom we have demonstrated the mosaic form of the Gm(b) factor [2,3]. Table III shows examples which emphasize the amplitude of the variations in phenotype frequency in these races according to the anti-Rh used with a single agglutinating serum.…”

Genes and Immunoglobulins

“…Similar considerations led STEINBERG [70] to reject a 2-locus 1 hypothesis and conclude 'that it seems wise to retain the simple assumption that a series of alleles a t a single locus determine the Gm factors'. Of the 8 conceivable gametic combinations of the 3 specificities Gm(a), (f) and (bl), at least 6 have already been observed; abl i s predominant in Negroes, and afb1 in some Chinese populations; j7P and a are the most common ones in Caucasians, f and b1 have been seen in some families [43, 481 and a statistical analysis by ROPARTZ et al [65] suggests the existence of afil or ab1 in Europeans, too. Economy of thought demands that Gm(a), (f) and (b1) be regarded as separate elements not only in serological description, but also in the genetic STEINBERC made the following definition in the paper referred to: u.. .…”

QUANTITATIVE STUDIES OF Gm ALLOTYPES II. G1m(1), G3m(5) AND G3m(21) IN SERA FROM HEALTHY CAUCASOID BLOOD DONORS, AND IN A FAMILY WITH THE INHERITANCE OF A GENE RESPONSIBLE FOR A WEAK Gm1, 17, 21, HAPLOTYPE

“…Thus, according to the observed phenotype, I V , could possess a Grn1i5 gene, and therefore an illegitimacy might be inferred because neither of the parents had this haplotype. But the GrnIi5 haplotype is rare in Caucasoid populations without negroid admixture (Ropartz et al, 1965;Steinberg, 1969). Furthermore, this child possesses the irregular expression of the Gm'*17 gene noticed in other members of the family.…”