2010
DOI: 10.2337/db10-0145
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Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight

Abstract: OBJECTIVEThe angiopoietin-like protein 4 (Angptl4)/fasting-induced adipose factor (Fiaf) is known as a regulator of peripheral lipid and glucose metabolism. In the present study, we investigated the physiological role of Angptl4 in central regulation of body weight homeostasis.RESEARCH DESIGN AND METHODSHypothalamic Angptl4 expression levels were measured using immunoblot assay during feeding manipulation or after administration of leptin, insulin, and nutrients. The effects of Angptl4 on food intake, body wei… Show more

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Cited by 105 publications
(89 citation statements)
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“…Indeed, the array of signals that modulate Angptl4 expression is likely to be diverse and tissue-specific. In the hypothalamus, for example, it was recently shown that Angptl4 levels in mice are increased by the CNS administration of leptin or insulin or the intake of dietary macronutrients (36). On the other hand, both leptin and insulin may signal to repress Angptl4 expression in peripheral tissues (37).…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, the array of signals that modulate Angptl4 expression is likely to be diverse and tissue-specific. In the hypothalamus, for example, it was recently shown that Angptl4 levels in mice are increased by the CNS administration of leptin or insulin or the intake of dietary macronutrients (36). On the other hand, both leptin and insulin may signal to repress Angptl4 expression in peripheral tissues (37).…”
Section: Discussionmentioning
confidence: 99%
“…It has further been suggested that Angptl4 has an important role in central regulation of energy metabolism ( 3 ). Intracerebroventricular administration of Angptl4 suppressed food intake and body weight gain, and enhanced energy expenditure, whereas Angptl4-null mice displayed increased body weight, but reduced energy expenditure ( 3 ).…”
Section: Statistical Analysesmentioning
confidence: 92%
“…Hypothalamic Fiaf expression is regulated by physiological appetite regulators and mediates their anorexigenic effects via inhibition of hypothalamic AMPK activity. Therefore, Fiaf appears to have an important role in central regulation of energy metabolism (63). Manipulation of Fiaf by the microflora seems to be a prototypic model of its remote control of host physiology (Figure 1).…”
Section: Gut Microbiota Regulate Host Genes That Control Metabolic Prmentioning
confidence: 99%