Objective: Optimizing reproductive efficiency in terms of estrus induction and production performance using simplified hormonal intervention using GnRH, gonadotropins and progesterone at farmers field conditions to bred animals with superior quality semen and also to reduce the maintenance cost. Method: The present study was planned for optimizing reproductive efficiency using four different easily available hormonal agents with simplified protocols at farmers field. A total of 126 females were used in the study. Hormonal protocols I, II, III and IV using GnRH + (PMSG+ hCG), (PMSG+ hCG), PMSG alone and prepared progesterone gel respectively were used for estrus induction in gilts and sows. Results: The estrus induction/rate was (77.77%, 81.36%, 78.57% and 50% respectively. The corresponding figures for interval (hrs) of heat exhibition from hormonal administration (121.33&4.93, 121.54&3.60, 78.52&4.52 and 192&24), conception rate (%) (72.22%, 81.25%, 68.18% and 33.33%) farrowing rate (55.55%, 68.29%, 68.18% and 33.33 %), total litter size at birth (7.2&0.64, 7.90&0.47, 8.90&0.47 and 7.00&0) and hormonal cost (Rs.) per animal (570, 335, 280 and 250 Rs.) were respectively. The easier to use protocol was III followed by II, I and IV. Conclusion: It was found that protocol II and III are effective and easier so can be used for optimizing reproductive efficiency in pigs at farmers field.