Hypothalamic dopamine and serotonin in the regulation of food intake

Meguid, Michael M.; Fetissov, Sergueı̈ O.; Varma, Madhu; Sato, Tomoi; Zhang, Lihua; Laviano, Alessandro; Fanelli, Filippo Rossi

doi:10.1016/s0899-9007(00)00449-4

Cited by 374 publications

(228 citation statements)

References 108 publications

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“…These monoamines and peptides include serotonin, norepinephrine, dopamine, neuropeptide Y, and corticotropin-releasing hormone. 35,36 With respect to metabolic processes, both obesity and depression have been associated with glucose intolerance, insulin resistance, and diabetes. 37 As a result, associations between depression and body weight are not surprising.…”

Section: Discussionmentioning

confidence: 99%

Depressive symptoms during childhood and adult obesity: the Zurich Cohort Study

et al. 2005

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Depression and obesity have become major health problems with increasing prevalence. Given the limited effectiveness of treatment for weight problems, the identification of novel, potentially modifiable risk factors may provide insights on new preventive approaches to obesity. The purpose of this study was to test the hypothesis that depressive symptoms during childhood are associated with weight gain and obesity during young adulthood. Participants were from a prospective community-based cohort study of young adults (N ¼ 591) followed between ages 19 and 40 years. The sample was stratified to increase the probability of somatic and psychological syndromes. Information was derived from six subsequent semistructured diagnostic interviews conducted by professionals over 20 years. The outcome measures were body mass index (BMI) and obesity (BMI430). Among women, depressive symptoms before age 17 years were associated with increased weight gain (4.8 vs 2.6% BMI increase per 10 years) representing greater risk for adult obesity (hazard ratio ¼ 11.52, Po0.05). Among men, only after controlling for confounders, depressive symptoms before age 17 years were associated with increased weight gain (6.6 vs 5.2% BMI increase per 10 years) in adulthood but not with occurrence of obesity. These associations between childhood depressive symptoms and adult body weight were adjusted for baseline body weight, a family history of weight problems, levels of physical activity, consumption of alcohol and nicotine, and demographic variables. As the magnitude of the associations was high, and depression during childhood is a prevalent and treatable condition, this finding may have important clinical implications for the prevention and treatment of obesity. Whether the results of this study are limited to populations with elevated levels of psychopathology remains to be tested. Molecular Psychiatry (2005) 10, 842-850.

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Section: Discussionmentioning

confidence: 99%

Depressive symptoms during childhood and adult obesity: the Zurich Cohort Study

et al. 2005

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“…Evidence for heritability and familial association comes from studies in identical twins showing that melancholic and atypical depressive subtypes independently aggregate in families and are at least in part genetically determined, and that these subtypes are most clearly distinguished by a different pattern of appetite and weight change (Kendler et al, 1996). Finally, appetite-associated endophenotypes for depression seem to be biologically plausible given that brain monoamines and peptides that play major roles in major depression, such as serotonin, norepinephrine, dopamine, neuropeptide Y, and corticotropin-releasing hormone, also play important roles in the regulation of food intake and body weight (Gillard et al, 1993;Meguid et al, 2000;Wang et al, 2001).…”

Section: Neurovegetative Signsmentioning

confidence: 99%

Discovering Endophenotypes for Major Depression

Hasler

Drevets

Manji

et al. 2004

Neuropsychopharmacol

1,026

739

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The limited success of genetic studies of major depression has raised questions concerning the definition of genetically relevant phenotypes. This paper presents strategies to improve the phenotypic definition of major depression by proposing endophenotypes at two levels: First, dissecting the depressive phenotype into key components results in narrow definitions of putative psychopathological endophenotypes: mood bias toward negative emotions, impaired reward function, impaired learning and memory, neurovegetative signs, impaired diurnal variation, impaired executive cognitive function, psychomotor change, and increased stress sensitivity. A review of the recent literature on neurobiological and genetic findings associated with these components is given. Second, the most consistent heritable biological markers of major depression are proposed as biological endophenotypes for genetic studies: REM sleep abnormalities, functional and structural brain abnormalities, dysfunctions in serotonergic, catecholaminergic, hypothalamic-pituitary-adrenocortical axis, and CRH systems, and intracellular signal transduction endophenotypes. The associations among the psychopathological and biological endophenotypes are discussed with respect to specificity, temporal stability, heritability, familiality, and clinical and biological plausibility. Finally, the case is made for the development of a new classification system in order to reduce the heterogeneity of depression representing a major impediment to elucidating the genetic and neurobiological basis of this common, severe, and often life-threatening illness.

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“…4 Hypothalamic DA has an important role in neuroendocrine functions, particularly prolactin secretion, 5 and is known to regulate food intake. 6,7 The nigrostriatal pathway (damaged in Parkinson's disease) is critical for the generation of movement. There are currently five known DA receptors, all of which are G-protein-coupled receptors.…”

Section: Reward Circuitrymentioning

confidence: 99%

High-fat diet alters the dopamine and opioid systems: effects across development

Reyes

2012

Int J Obes Supp

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Consumption of a high-fat diet has been linked to obesity, dyslipidemia and cardiovascular disease. Less well appreciated are adverse effects on the brain and behavior. Recent research has shown that consumption of a high-fat diet can alter gene expression within the brain, and the dopamine and opioid neurotransmitter systems appear to be vulnerable to dysregulation. This review will focus on recent reports in both humans and animal models that describe adverse effects of high-fat diet consumption on the central reward circuitry. In addition, the importance of different development windows will be discussed, with effects observed in both the prenatal/perinatal time period and with chronic high-fat diet consumption in adulthood.

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Hypothalamic dopamine and serotonin in the regulation of food intake

Cited by 374 publications

References 108 publications

Depressive symptoms during childhood and adult obesity: the Zurich Cohort Study

Depressive symptoms during childhood and adult obesity: the Zurich Cohort Study

Discovering Endophenotypes for Major Depression

High-fat diet alters the dopamine and opioid systems: effects across development

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