Hypothalamic‐pituitary‐adrenal and ‐thyroid axis dysfunctions and decrements in the availability of L‐tryptophan as biological markers of suicidal ideation in major depressed females

Maes, Michaël; Vandewoude, M.; Schotte, Christiaan; Martin, M.; Blockx, P.; Cosyns, Paul

doi:10.1111/j.1600-0447.1989.tb01294.x

Cited by 27 publications

(19 citation statements)

References 25 publications

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“…In other disasters, such as, earthquakes and storms, there is a gradient of destruction from the epicenter. The Enschede fireworks factory disaster affected people who came from a defined geographical region [21, 22]. In these circumstances, disaster services should be carefully integrated with the existing primary and secondary health care networks that particular people use at such times.…”

Section: Types Of Disastersmentioning

confidence: 99%

Mental Health Services Required after Disasters: Learning from the Lasting Effects of Disasters

McFarlane

Williams

2012

Depression Research and Treatment

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Disasters test civil administrations’ and health services’ capacity to act in a flexible but well-coordinated manner because each disaster is unique and poses unusual challenges. The health services required differ markedly according to the nature of the disaster and the geographical spread of those affected. Epidemiology has shown that services need to be equipped to deal with major depressive disorder and grief, not just posttraumatic stress disorder, and not only for victims of the disaster itself but also the emergency service workers. The challenge is for specialist advisers to respect and understand the existing health care and support networks of those affected while also recognizing their limitations. In the initial aftermath of these events, a great deal of effort goes into the development of early support systems but the longer term needs of these populations are often underestimated. These services need to be structured, taking into account the pre-existing psychiatric morbidity within the community. Disasters are an opportunity for improving services for patients with posttraumatic psychopathology in general but can later be utilized for improving services for victims of more common traumas in modern society, such as accidents and interpersonal violence.

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Section: Types Of Disastersmentioning

confidence: 99%

Mental Health Services Required after Disasters: Learning from the Lasting Effects of Disasters

McFarlane

Williams

2012

Depression Research and Treatment

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“…Based on the included studies, there may be associations between neuropeptides and suicidal behavior but this does not imply the existence of a causal link. Most studies (thirtheen) [33, 34, 83–85, 89, 90, 92–96, 101] included in our review found an association between neuropeptides and suicidal behavior; however, there are also six studies [86, 91, 98–100, 102] that did not confirm this association. Moreover, there are other studies suggesting that neuropeptides abnormalities may be found in subjects with MDD but not suicidal behavior [87, 88, 97].…”

Section: Discussionmentioning

confidence: 88%

“…Also, Ordway et al [99] found no significant differences in NPY concentrations between suicide victims with MDD (with comorbid alcohol dependence) and age-matched control subjects. Finally, Maes et al [102] reported no significant differences in TSH, FT4, ACTH, and total L-TRP levels between patients with suicidal ideation and those without.…”

Section: Resultsmentioning

confidence: 99%

The Role of Neuropeptides in Suicidal Behavior: A Systematic Review

Serafini

Pompili

Lindqvist

et al. 2013

BioMed Research International

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There is a growing evidence that neuropeptides may be involved in the pathophysiology of suicidal behavior. A critical review of the literature was conducted to investigate the association between neuropeptides and suicidal behavior. Only articles from peer-reviewed journals were selected for the inclusion in the present review. Twenty-six articles were assessed for eligibility but only 22 studies were included. Most studies have documented an association between suicidality and some neuropeptides such as corticotropin-releasing factor (CRF), VGF, cholecystokinin, substance P, and neuropeptide Y (NPY), which have been demonstrated to act as key neuromodulators of emotional processing. Significant differences in neuropeptides levels have been found in those who have attempted or completed suicide compared with healthy controls or those dying from other causes. Despite cross-sectional associations between neuropeptides levels and suicidal behavior, causality may not be inferred. The implications of the mentioned studies were discussed in this review paper.

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“…PTSS-10 is a 10-item scale, which measures posttraumatic stress symptoms including hyperarousal on a Likert scale where 1 represents "never/seldom" and 7 represents "very often", with scores ranging from 10 to 70 [5,18,19]. …”

Section: Methodsmentioning

confidence: 99%

The casualty chain inventory: a new scale for measuring peritraumatic responses: a cross-sectional study

et al. 2011

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BackgroundPeritraumatic psychological- and sensory impressions in victims of civilian accidents are only partly understood. This study scrutinizes the level and duration of perceived psychological threat at scene of injury as well as in hospital (the casualty chain) measured by the Casualty Chain Inventory (CCI). The purpose of the study was to assess and validate the CCI, and to examine the correlations between the new instrument and stress responses measured by the Impact of Event Scale (IES) and the Post-traumatic Stress Scale-10 (PTSS-10)MethodsThree hundred and fifteen injured, conscious, hospitalised patients were assessed with a self-report questionnaire. The CCI consists of eight items including sensory impressions and well-known psychological responses to trauma.ResultsThe internal consistency of the CCI was solid (Cronbach's alpha: .83-.85). A factor analysis revealed two components, "perception" and "dissociation". The instrument correlates significantly with the Impact of Event Scale (r = 0.47 - 0.54) and the Posttraumatic Stress Scale-10 (r = 0.32 - 0.50). The explained variance is high both at the scene of injury (61%) and in the hospital (65%). Dissociation and perception either used as a two-factor solution or as a sum score measured in the hospital, gave the strongest prediction for later psychological distress.ConclusionsThe CCI appears to be a useful screening instrument for, at an early state, identifying patients hospitalized after a physical incident at risk for subsequent psychological distress.

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Hypothalamic‐pituitary‐adrenal and ‐thyroid axis dysfunctions and decrements in the availability of L‐tryptophan as biological markers of suicidal ideation in major depressed females

Cited by 27 publications

References 25 publications

Mental Health Services Required after Disasters: Learning from the Lasting Effects of Disasters

Mental Health Services Required after Disasters: Learning from the Lasting Effects of Disasters

The Role of Neuropeptides in Suicidal Behavior: A Systematic Review

The casualty chain inventory: a new scale for measuring peritraumatic responses: a cross-sectional study

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