2003
DOI: 10.1016/s0165-1781(03)00175-6
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Hypothalamic–pituitary–adrenal axis responses to stress in subjects with 3,4-methylenedioxy-methamphetamine (‘ecstasy’) use history: correlation with dopamine receptor sensitivity

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Cited by 58 publications
(54 citation statements)
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References 29 publications
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“…Furthermore, cortisol was elevated in the afternoon sample which was obtained in the laboratory immediately prior to an acutely stressful cognitive challenge. This finding is analogous to previous observations of elevated cortisol immediately prior to a laboratory stressor (Gerra et al, 2003) and suggests that users may have a greater negative perception of the forthcoming challenge (Gerra et al, 1998). Although activation of cortisol in anticipation of and in response to stress is adaptive, allowing the host to mobilise the resources necessary to deal with threat, excessive or inappropriate responding increases allostatic load (McEwen 1998) and the risk of deleterious consequences for ill-health.…”
Section: Diurnal Cortisolsupporting
confidence: 83%
See 1 more Smart Citation
“…Furthermore, cortisol was elevated in the afternoon sample which was obtained in the laboratory immediately prior to an acutely stressful cognitive challenge. This finding is analogous to previous observations of elevated cortisol immediately prior to a laboratory stressor (Gerra et al, 2003) and suggests that users may have a greater negative perception of the forthcoming challenge (Gerra et al, 1998). Although activation of cortisol in anticipation of and in response to stress is adaptive, allowing the host to mobilise the resources necessary to deal with threat, excessive or inappropriate responding increases allostatic load (McEwen 1998) and the risk of deleterious consequences for ill-health.…”
Section: Diurnal Cortisolsupporting
confidence: 83%
“…These pre-drug elevations could be attributed to the frequency of clubbing and ecstasy consumption, for example the majority of the sample described themselves as regular clubbers (Wolff et al, 2012) and have taken ecstasy up to 150 times (Parrott et al, 2008), and subsequent ecstasy-induced elevations of cortisol. Further evidence for a potential alteration in basal HPA activity is offered by Gerra et al (2003) who assessed levels of cortisol immediately before and after an acute laboratory stressor in recreational users of ecstasy and non-drug using controls.…”
Section: Introductionmentioning
confidence: 99%
“…Given the well-known role of DA in modulating activity, it is possible that the reduced ambulation and rearing observed in the MDMA-treated animals was due to abnormalities in the dopaminergic system. In addition to the previously mentioned ability of high MDMA doses to acutely release catecholamines, longer lasting alterations in catecholaminergic function have been reported not only in mice (which are known to exhibit dopamine neurotoxicity following MDMA), but also in rats, monkeys, and humans exposed to this compound (Commins et al, 1987;Gerra et al, 2002Gerra et al, , 2003Mayerhofer et al, 2001;McCann et al, 1994;Ricaurte et al, 1992). Moreover, we recently found that the same MDMA binge regimen used in the present study (ie with a 1-h interdose interval) significantly reduced DA transporter binding in the striatum .…”
Section: Discussionmentioning
confidence: 95%
“…Other clinical and physiological abnormalities that have been reported in MDMA users include impulsivity (Morgan et al, 2006;Quednow et al, 2007), neuroendocrine dysfunction (Gerra et al, 1998(Gerra et al, , 2000(Gerra et al, , 2003McCann et al, 2000;Verkes et al, 2001), alterations in pain modulation (O'Regan and Clow, 2004), sleep architecture (Allen et al, 1993;Ricaurte and McCann, 2001), visual-evoked potentials (Casco et al, 2005), and event-related potentials (Mejias et al, 2005). Like cognitive function, all of these behavioral spheres are known to be influenced, in part, by brain 5-HT systems.…”
Section: Introductionmentioning
confidence: 99%