Hypothalamic-Pituitary-Adrenal (HPA) Axis Functioning among Patients with Schizophrenia: A Cross Sectional Comparative Study

Singh, Mamta; Rk, Solanki; Bagaria, Bhawna; K, Mukesh Swami

doi:10.4172/psychiatry.1000211

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…Thus, the HPA axis has been one of the most attractive research targets to understand the pathophysiology of schizophrenia for decades. Increased cortisol levels have been determined in patients with schizophrenia and even in individuals at high risk for schizophrenia compared with controls (Mittal and Walker, 2011;Carol and Mittal, 2015;Singh et al, 2015). However, mean baseline cortisol level measurements in schizophrenia are not consistent in the literature (Bradley and Dinan, 2010).…”

Section: Schizophreniamentioning

confidence: 99%

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Kırlıoğlu

Balcıoğlu

2019

Preprint

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Several lines of evidence support a relationship between circadian disruption in the onset, course, and maintenance of mental disorders. Despite the study of circadian phenotypes promising a decent understanding of the pathophysiologic or etiologic mechanisms of psychiatric entities, several questions still need to be addressed. In this review, we aimed to synthesize the literature investigating chronobiologic theories and their associations with psychiatric entities. We first introduced molecular elements and mechanisms of the circadian system to promote a better understanding of the chronobiologic implications of mental disorders. Then, we comprehensively and systematically reviewed circadian system studies in mood disorders, schizophrenia, and anxiety disorders. Current research has demonstrated that circadian pathologies, including genetic and neurohumoral alterations, represent the neural substrates of the pathophysiology of many psychiatric disorders. However, much more work is needed to identify the causal relationship between circadian physiology abnormalities and mental disorders, and to develop sound pharmacologic interventions.

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Section: Schizophreniamentioning

confidence: 99%

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Kırlıoğlu

Balcıoğlu

2019

Preprint

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Correlation Between the Different Types of Antipsychotics and Serum Cortisol, Dehidroepiandrosterone Sulfat and their Ratio in Schizophrenia

Babinkostova

Manuseva

Marković

2022

Prilozi

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Background: Evidence for disturbances in HPA activation and abnormal HPA regulatory mechanisms in schizophrenia is accumulating. Aim: To compare serum levels of cortisol, DHEA-S and their ratio between patients with schizophrenia and healthy controls and among patients before and after treatment with different types of antipsychotics. Material and methods: In this clinical prospective study, 60 patients with schizophrenia and 40 healthy age and sex matched control subjects were included. All patients experienced an acute exacerbation of the illness (PANSS: P1 and P3 ≥ 4). Clinical evaluation of patients was performed using the Positive and Negative Symptom Scale. A questionnaire for socio-demographic and clinical data collection was used. Serum levels of cortisol, DHEA-S and their ratio were measured at baseline in all participants and after 3 and 6 weeks, respectively, of the antipsychotic treatment with different types of antipsychotics in patients with schizophrenia. Results: Patients with schizophrenia had significantly higher serum cortisol and DHEA-S levels in comparison to the control group. There was no significant difference in serum levels of cortisol, DHEA-S and their ratio between patients treated with different types of antipsychotics (typical/atypical). Serum levels of the analyzed hormones significantly reduce during the 6-week period of examination in both subgroups treated with different types of antipsychotics. Conclusion: Elevated serum cortisol and DHEA-S in schizophrenic patients might be associated with their role in the pathophysiology of the disorder. There is no significant difference in serum levels of cortisol, DHEA-S and their ratio among the patients treated with different types of antipsychotics.

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Hypothalamic-Pituitary-Adrenal (HPA) Axis Functioning among Patients with Schizophrenia: A Cross Sectional Comparative Study

Cited by 2 publications

References 48 publications

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Correlation Between the Different Types of Antipsychotics and Serum Cortisol, Dehidroepiandrosterone Sulfat and their Ratio in Schizophrenia

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