Hypothalamic Projections to the Optic Tectum in Larval Zebrafish

Heap, Lucy A.; Vanwalleghem, Gilles; Thompson, Andrew W.; Favre‐Bulle, Itia A.; Rubinsztein‐Dunlop, Halina; Scott, Ethan K.

doi:10.3389/fnana.2017.00135

Cited by 33 publications

(34 citation statements)

References 96 publications

(131 reference statements)

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“…Therefore, it seems that zebrafish type X cells probably receive direct retinal information, among other types of inputs. Results in zebrafish larva have shown afferents to the optic tectum from fifteen different areas (Kunst et al, the dorsal raphe (Yokogawa et al, 2012;Filosa et al, 2016), hypothalamus (Heap et al, 2018a) and thalamus (Heap et al, 2018b), among other areas (Kunst et al, 2019). As a result, this and other areas could modulate the toro-tectal circuit in zebrafish (see "Anatomical and Functional Considerations of the OT-TL Circuit: Possible Relationship With Other Circuits" below).…”

Section: Reciprocal Toro-tectal Connectionsmentioning

confidence: 99%

“…Larval zebrafish are nowadays a prime vertebrate model to dissect the anatomy and function of neural circuits using neurogenetic and optogenetic methods (Wyatt et al, 2015;White, 2016;Förster et al, 2017;Robles, 2017;Vanwalleghem et al, 2018). Although a number of studies have analyzed the anatomical organization, cell types, connectivity and function of the optic tectum in zebrafish larvae Nevin et al, 2010;Robles et al, 2011Robles et al, , 2013Robles et al, , 2014Corbo et al, 2012;Yokogawa et al, 2012;Heap et al, 2013Heap et al, , 2018aPortugues et al, 2014;Temizer et al, 2015;Bianco and Engert, 2015;Dunn et al, 2016;Filosa et al, 2016;; Helmbrecht et al, 2018;Kunst et al, 2019), little is known about TL. To our knowledge, only two studies have described aspects of the toro-tectal circuit in zebrafish larva.…”

Section: Introductionmentioning

confidence: 99%

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Anatomy and Connectivity of the Torus Longitudinalis of the Adult Zebrafish

Folgueira

Riva-Mendoza

Ferreño-Galmán

et al. 2020

Front. Neural Circuits

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This study describes the cytoarchitecture of the torus longitudinalis (TL) in adult zebrafish by using light and electron microscopy, as well as its main connections as revealed by DiI tract tracing. In addition, by using high resolution confocal imaging followed by digital tracing, we describe the morphology of tectal pyramidal cells (type I cells) that are GFP positive in the transgenic line Tg(1.4dlx5a-dlx6a:GFP) ot1 . The TL consists of numerous small and medium-sized neurons located in a longitudinal eminence attached to the medial optic tectum. A small proportion of these neurons are GABAergic. The neuropil shows three types of synaptic terminals and numerous dendrites. Tracing experiments revealed that the main efference of the TL is formed of parallel-like fibers that course within the marginal layer of the optic tectum. A toral projection to the thalamic nucleus rostrolateralis is also observed. Afferents to the TL come from visual and cerebellum-related nuclei in the pretectum, namely the central, intercalated and the paracommissural pretectal nuclei, as well as from the subvalvular nucleus in the isthmus. Additional afferents to the TL may come from the cerebellum but their origins could not be confirmed. The tectal afferent projection to the TL originates from cells similar to the type X cells described in other cyprinids. Tectal pyramidal neurons show round or piriform cell bodies, with spiny apical dendritic trees in the marginal layer. This anatomical study provides a basis for future functional and developmental studies focused on this cerebellum-like circuit in zebrafish.

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Section: Reciprocal Toro-tectal Connectionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anatomy and Connectivity of the Torus Longitudinalis of the Adult Zebrafish

Folgueira

Riva-Mendoza

Ferreño-Galmán

et al. 2020

Front. Neural Circuits

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“…Projections from the posterior tuberculum (PT) to the habenula have been previously reported (Hendricks & Jesuthasan, 2007;Turner et al, 2016). However, neurons in the posterior tuberculum have been characterized as largely non-GABAergic (Filippi et al, 2014;Heap et al, 2017). The nucleus adjacent to the posterior tuberculum is likely to be the M2 migrated nuclei of the posterior tuberculum, which is a part of the preglomerular complex that receives sensory information from various sensory systems,…”

Section: Discussionmentioning

confidence: 99%

“…Retrogradely labelled neurons in the entopeduncular nucleus were DsRed-negative ( Fig 2C). Injection into either left or right lateral habenula also retrogradely labelled cells lateral to the posterior tuberculum ( Figure. 2D, E; n = 9 fish imaged), which is likely to be the migrated M2 nucleus of the preglomerular complex (Heap et al, 2017). Label was bilateral, and a small number of the neurons were positive for DsRed, indicating that this nucleus sends GABAergic projections to the lateral habenula.…”

Section: Neuronal Tracing Identifies Source Of Gabaergic Afferentsmentioning

confidence: 98%

Identification of GABAergic neurons innervating the zebrafish lateral habenula

Ramaswamy

Cheng

Jesuthasan

2019

Preprint

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Equations: 0 Total number of words: 5191 Number of words in abstract: 177 2 Abstract Habenula neurons are constantly active. The level of activity affects mood and behaviour, with increased activity in the lateral habenula reflecting exposure to punishment and a switch to passive coping and depression. Here, we identify GABAergic neurons that could influence activity in the lateral habenula of larval zebrafish. GAD65/67 immunohistochemistry and imaging of gad1b:DsRed transgenic fish suggest the presence of GABAergic terminals in the lateral habenula. Retrograde tracing with the lipophilic dye DiD indicates that this GABAergic innervation derives from the thalamus and a nucleus lateral to the posterior tuberculum, the putative M2 nucleus. Two-photon calcium imaging indicates that blue light causes excitation of thalamic GABAergic neurons and concomitant inhibition of a subpopulation neurons in the lateral habenula. Whole-cell recording confirmed that blue-light induced hyperpolarization of lateral habenula neurons. No response to blue light was detected in the putative M2 neurons. These observations suggest that GABAergic input from the thalamus mediates inhibition of the zebrafish lateral habenula, possibly contributing to the beneficial effects of blue light. Stimuli acting via the putative preglomerular complex remain to be defined.

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“…Furthermore, in Polypterus, visual projection to the pallium is mediated via the nucleus medianus of the posterior tuberculum (MTP; Figure 9), which is considered to be uniquely derived in this group and not homologous to any known pathways in tetrapods (Northcutt et al, 2004;Northcutt, 2009). Indeed, there are more than two ascending pathways, with a variable abundance of each pathway depending on species (Riss and Jakway, 1970;Graybiel, 1972;Benevento and Standage, 1983;Gamlin and Cohen, 1986;Albert et al, 1999;Wild and Gaede, 2016;Heap et al, 2017).…”

Section: Evolution Of Ascending Visual Pathwaysmentioning

confidence: 99%

Non-thalamic origin of zebrafish sensory relay nucleus: convergent evolution of visual pathways in amniotes and teleosts

Hagio

Thomas

Heuzé

et al. 2020

Preprint

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Ascending visual projections similar to the mammalian thalamocortical pathway are found in a wide range of vertebrate species, but their homologous relationship is debated. To get better insights into their evolutionary origin, we examined the developmental origin of a visual relay nucleus in zebrafish (a teleost fish). Similarly to the tectofugal visual thalamic nuclei in amniotes, the lateral part of the preglomerular complex (PG) in teleosts receives tectal information and projects to the pallium.However, our cell lineage study reveals that the majority of PG cells are derived from the midbrain, not from the forebrain. We also demonstrate that the PG projection neurons develop gradually until juvenile stage, unlike the thalamic projection neurons.Our data suggest that teleost PG is not homologous to the amniote thalamus and that thalamocortical-like projections can evolve from a non-forebrain cell population. Thus, sensory pathways in vertebrate brains exhibit a surprising degree of variation.ventral telencephalon containing the striatum; Figure 1; amphibians; Th  SPa), with little projections to the pallium (Kicliter, 1979; Neary and Northcutt, 1983; Wilczynski and Northcutt, 1983; Butler, 1994a).Outside of tetrapods, brain structures are highly divergent compared to amniotes, and thus it is even more complicated to draw an evolutionary scenario. Although teleosts also have sensory afferents to the pallium, the morphology of the teleost pallium is very different from that of tetrapods, as the developmental processes are different (evagination in tetrapods versus eversion in teleosts). Different authors have proposed several hypotheses concerning which part of the teleost pallium would correspond to the mammalian neocortex (Braford, 1995; Wullimann and Mueller, 2004;Northcutt, 2006;Yamamoto et al., 2007; Mueller et al., 2011). Recently, cell lineage studies of the zebrafish pallium have modified the classical view of the eversion model (Dirian et al., 2014;Furlan et al., 2017), and we have proposed a new interpretation on the pallial homology .In teleosts, the controversy is not only on the pallial homology. It has also been debated whether or not the structure giving rise to the major pallial projections is homologous to the tetrapod thalamus (Wullimann and Rink, 2002;Northcutt, 2006;Yamamoto and Ito, 2008; Mueller, 2012). This structure is named the preglomerular complex (PG; Figure 1; teleosts; PG  Pal). In order to determine the evolutionary scenario of sensory pathways in bony vertebrates (Osteichthyes), it is important to investigate whether or not the teleost PG is homologous to the amniote thalamus.As for the controversy on the pallial homology, different authors claim different hypotheses. On the one hand, based on descriptive embryology, the teleost PG has been considered to originate from the basal portion of the diencephalon, the posterior tuberculum (Bergquist, 1932; Braford and Northcutt, 1983; Butler and Hodos, 2005; 6

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Hypothalamic Projections to the Optic Tectum in Larval Zebrafish

Cited by 33 publications

References 96 publications

Anatomy and Connectivity of the Torus Longitudinalis of the Adult Zebrafish

Anatomy and Connectivity of the Torus Longitudinalis of the Adult Zebrafish

Identification of GABAergic neurons innervating the zebrafish lateral habenula

Non-thalamic origin of zebrafish sensory relay nucleus: convergent evolution of visual pathways in amniotes and teleosts

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