Hypothalamic substrates for brain stimulation-induced patterns of locomotion and escape jumps in the rat

Lammers, J.H.C.M.; Kruk, Menno R.; Meelis, W.; Poel, A.M. van der

doi:10.1016/0006-8993(88)91045-1

Cited by 117 publications

(61 citation statements)

References 44 publications

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“…11), one hypothesis is that direct excitatory drive to the LHAjd results in increased defensive behavior; this hypothesis is consistent with studies showing that electrical (Kruk et al, 1983;Lammers et al, 1988b) or chemical stimulation with glutamate agonists (Roeling et al, 1990(Roeling et al, , 1991 of the LHAjp/rostral LHAjd region elicits motor responses indicative of defensive behavior. To add further functional perspective to this hypothesis, one region to consider is the hippocampal formation (HPF), specifically the subiculum, which provides a massive input to the LHAjd-clearly any (for example) locational information relayed by hippocampal neurons to the LHAjd could have obvious relevance if the LHAjd is an integral part of a system for the control of defensive behavior.…”

Section: Cerebral Cortexsupporting

confidence: 59%

“…A major theme of the discussion in our previous work on the LHAjp (Hahn and Swanson, 2010) was how its connections indicated a possible role in the control of defensive behavior, a role indicated more demonstrably by defensive responses (attack bites and bouts of jumping) reported to occur following direct electrical stimulation of a region corresponding to the LHAjp (Kruk et al, 1983;Lammers et al, 1988b), and also relatedly by selfgrooming behavior (possibly defensive displacement behavior) following the injection of glutamate agonists into the same region (Roeling et al, 1990(Roeling et al, , 1991. In particular we considered the relation of LHAjp connections to regions that are (on the basis of functional and neuroanatomical studies) indicated to be components of a medial hypothalamic zone defensive behavior system (Canteras, 2002).…”

Section: Discussionmentioning

confidence: 99%

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Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Hahn

Swanson

2012

J of Comparative Neurology

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The connections of the lateral hypothalamic area juxtadorsomedial region (LHAjd) were investigated in a series of pathway-tracing experiments involving iontophoretic co-injection of the tracers Phaseolus vulgaris-leucoagglutinin (PHA-L; for outputs) and cholera toxin B subunit (CTB; for inputs). Results revealed that the LHAjd has connections with some 318 distinct gray matter regions encompassing all four subsystems-motor, sensory, cognitive, and behavioral state -included in a basic structure-function network model of the nervous system. Integration of these subsystems is necessary for the coordination and control of emotion and behavior, and in that regard the connections of the LHAjd indicate that it may have a prominent role. Furthermore, the LHAjd connections, together with the connections of other LHA differentiations studied similarly to date, indicate a distinct topographic organization that suggests each LHA differentiation has specifically differing degrees of involvement in the control of multiple behaviors. For the LHAjd, its involvement to a high degree in the control of defensive behavior, and to a lesser degree in the control of other behaviors, including ingestive and reproductive, is suggested. Moreover, the connections of the LHAjd suggest that its possible role in the control of these behaviors may be very broad in scope because they involve the somatic, neuroendocrine, and autonomic divisions of the nervous system. In addition, we suggest that connections between LHA differentiations may provide, at the level of the hypothalamus, a neuronal substrate for the coordinated control of multiple themes in the behavioral repertoire. INDEXING TERMShypothalamus; periaqueductal gray; hippocampal formation; behavior; motivation An emerging view of the lateral hypothalamic area (LHA) reveals a highly regionally differentiated neuronal architecture with correspondingly differentiated axonal connections characterized by an extensive divergent and convergent topographic organization (Swanson, 2004;Goto et al., 2005;Swanson et al., 2005;Hahn, 2010;Hahn and Swanson, 2010). Such an organization calls for an equivalently extensive comparative analysis of the underlying organization of the severally parceled LHA (16 provisional LHA regions within the hypothalamic lateral zone) (Swanson, 2004). In a previous article (Hahn and Swanson, 2010), we presented the results of a high-resolution analysis of the axonal inputs and outputs of the lateral hypothalamic area (LHA) juxtaparaventricular (LHAjp) and suprafornical (LHAs) regions-two differentiations of the hypothalamic lateral zone middle group within NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript respectively a medial (LHAjp) and perifornical (LHAs) tier of a recently revised parcellation for the LHA (Swanson, 2004;Swanson et al., 2005).The previous work showed that the LHAjp and LHAs have interregional connections with several hundred distinct gray matter regions encompassing all four subsystems (motor, sensory, cognitive, and...

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Section: Cerebral Cortexsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Hahn

Swanson

2012

J of Comparative Neurology

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“…Using electrical stimulation of different parts of the hypothalamus, a large number of behaviors were elicited, such as locomotion, feeding, drinking, aggression, digging and grooming. 34,[46][47][48] Thus, it is conceivable that different types of hypothalamically elicited behaviors require activation of different parts of the brain. 36 Then, in the present study, we investigated if the CeA afferent connections are actually involved in the hypergrooming induced by microinjection of OT in the CeA and we interpreted these results in the context of the pathophysiology of OCD.…”

Section: Introductionmentioning

confidence: 99%

Neuroanatomical and cellular substrates of hypergrooming induced by microinjection of oxytocin in central nucleus of amygdala, an experimental model of compulsive behavior

et al. 2007

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Oxytocin (OT) is a neurosecretory nonapeptide synthesized in hypothalamic cells that project to the neurohypophysis as well as to widely distributed sites in the central nervous system. Central OT microinjections induce a variety of cognitive, sexual, reproductive, grooming and affiliative behaviors in animals. Obsessive-compulsive disorder (OCD) includes a range of cognitive and behavioral symptoms that bear some relationship with OT. Here, we study the neuroanatomical and cellular substrates of the hypergrooming induced by administration of OT in the central nucleus of amygdala (CeA). In this context, this hypergrooming is considered as a model of compulsive behavior. Our data suggest a link between the CeA and the hypothalamic grooming area (HGA). The HGA includes parts of the paraventricular nucleus and the dorsal hypothalamic area. Our data on colocalization of OT (immunohistochemistry for peptide), OT receptor (binding assay) and its retrogradely labeled cells after Fluoro-Gold injection in the CeA suggest that CeA and connections are important substrates of the circuit underlying this OT-dependent compulsive behavioral pattern.

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“…The neural basis for such an anatomical dichotomy does not appear to exist, at least in rats. Electrical stimulation of the PVN does not elicit 'fight' or 'flight' behaviors, while electrical stimulation of the medial basal hypothalamus does elicit 'fight' and 'flight' behaviors (21,23,24).…”

Section: Chronic Impluntsmentioning

confidence: 94%

“…bites and attacks (23), and submissive, i.e. escape jump and flight, behaviors (24). GC receptors (25)(26)(27)(28)(29) and GC-responsive neurons ( I , 3, 30-32) are found throughout the more medial aspects of this 'hypothalamic aggression area' in rats and hamsters.…”

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confidence: 99%

Cortisol Exerts Site‐, Context‐ and Dose‐Dependent Effects on Agonistic Responding in Hamsters

Hayden-Hixson¹,

Ferris²

1991

J Neuroendocrinology

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Site-, context-and dose-dependent actions of intrahypothalamic cortisol administration on the agonistic behaviors of adult male golden hamsters (n = 128 dyads) were examined. W h e n cortisol-treated animals were tested in paired encounters with aggressive cholesterol-treated opponents, chronic ( 2 2 4 h ) cortisol treatment (1 mm implants) induced significant (P < 0.05) submission in three medial hypothalamic a r e a s (anterior hypothalamic area > medial preoptic area > ventromedial hypothalamus), but aggression in t h e paraventricular nucleus or third ventricle. In contrast, chronic cortisol treatment in the anterior hypothalamic area resulted in high levels of aggression during paired encounters with submissive opponents, and during territorial aggression tests with juvenile male intruders. Acute ( 1 2 0 min) cortisol treatment in the anterior hypothalamic area (100 nl injections) induced significant submission after lo-' M, but significant aggression after M microinjections in paired encounters with aggressive vehicleinjected opponents. These findings suggest glucocorticoid-sensitive mechanisms within the anterior hypothalamus modulate aggressive responding during intrasexual social encounters.Glucocorticoids (GC) are released and have profound effects on brain activity during all behaviorally-aroused circumstances whcIc adaptive responses to environmental stimuli occur (1 -4). Howcver, no evidence of a connection between the neurobiological events underlying hypothalamic-pituitary-adrenal (HPA) axis activation and regulation (5-lo), and the central conttol of agonistic responding exists (1 1 -16).Ri-ain stimulation and lesion studies identified an area within the medial and lateral hypothalamus that participates in 'hypothalamic aggression'. This area consists of a continuous and localized band of cells in the medial preoptic area (MPOA), anterior hypothalamic area (AHA), ventromedial hypothalamus (VMH), and lateral/perifornical hypothalamus in most mammalian species examined (17-22). In rats, electrical stimulation in the AHA, caudal MPOA and rostra1 VMH elicits both aggressive, i.e. bites and attacks (23), and submissive, i.e. escape jump and flight, behaviors (24). GC receptors (25-29) and GC-responsive neurons ( I , 3, 30-32) are found throughout the more medial aspects of this 'hypothalamic aggression area' in rats and hamsters. Systemic and direct administration of GC have complex, e 4 . excitatory, inhibitory or biphasic, effects on the spontaneous and evoked electrical activity of neurons in this region in rats and cats (3,7,31,33,34). In rats, sensory neurons within the medial hypothalamus are especially sensitive to the effects of direct GC administration (31).Complex bidirectional effects of GC are also observed in behavioral studies utilizing peripheral GC manipulations to examine the pharmacology of agonistic responding in rats, mice and hamsters (1 I , 16, 35). Systemic GC administration in intact animals, and GC replacement of adrenalectomized animals, can either increase aggressiv...

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Hypothalamic substrates for brain stimulation-induced patterns of locomotion and escape jumps in the rat

Cited by 117 publications

References 44 publications

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Neuroanatomical and cellular substrates of hypergrooming induced by microinjection of oxytocin in central nucleus of amygdala, an experimental model of compulsive behavior

Cortisol Exerts Site‐, Context‐ and Dose‐Dependent Effects on Agonistic Responding in Hamsters

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