Hypothalamic Syndrome. The Role of the Hypothalamus in the Formation of Eating Behavior and Obesity

Nikonova, L. V.; Tishkovskiy, S. V.; Butrim, O. S.; Davydchyk, E. V.

doi:10.25298/2221-8785-2019-17-4-355-360

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…Ожирение с розовыми стриями является ведущим симптомом гипоталамического синдрома пубертатного периода [11,12]. Данная эндокринная патология является следствием первичной незрелости гипоталамических структур [13] или вторичной дисфункции, вызванной структурно-функциональным повреждением гипоталамуса [14,15].…”

Section: обоснованиеunclassified

Markers of endothelial dysfunction in adolescent and young patients with hypothalamic syndrome

et al. 2020

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Background: Endothelial dysfunction is the first but reversible stage of atherosclerosis. A change in the functional state of the vascular endothelium, especially of a growing organism, can be the basis for the development of many diseases in adulthood. The study of the structural and functional state of peripheral vessels of adolescents with hypothalamic syndrome is extremely important for understanding of the mechanisms of formation of cardiometabolic risks.Aims: to compare the structural and functional state of the vascular wall of young men with hypothalamic syndrome and constitutionally exogenous obesity.Methods: During the study 360 males were examined (average age 21.27±2.44 years) and divided into 3 groups: group 1 -with hypothalamic syndrome (n=242); group 2 - with constitutionally exogenous obesity (n=98); control group - practically healthy individuals (n=20). Hypothalamic syndrome was verified in the presence of a symptom complex, including obesity and pink striae. Cross-group comparative analysis of results of clinical, laboratory and instrumental examination was carried out.Results: In the group of patients with hypothalamic syndrome, endothelium-dependent vasodilatation (9.44±1.26 versus 10.37±1.21%; p=0.001) and endothelium-independent vasodilatation (10.29±1.28 versus 11.29±1.14%; p=0.001) is worse than in the group of patients with constitutionally exogenous obesity, and the rate of endothelium-dependent vasodilatation is lower than the generally accepted norm. In addition, among patients with hypothalamic syndrome, the stiffness of the vascular wall is higher than among patients with constitutionally exogenous obesity (15.47±2.58 versus 13.24±3.84%; p=0.001). Statistically significant correlations were revealed between the structural and functional state of peripheral arteries and hemodynamic, hormonal, metabolic changes, and the level of C-reactive protein (p<0.05).Conclusions: The obtained data indicate a deterioration of endothelial function and an increase in vascular wall stiffness in obese patients, regardless of its etiology. The patients with hypothalamic syndrome have more pronounced structural and functional changes in the vascular wall are observed than patients with constitutionally exogenous obesity.

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Section: обоснованиеunclassified

Markers of endothelial dysfunction in adolescent and young patients with hypothalamic syndrome

et al. 2020

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“…The hypothalamus controls the activity of the human endocrine system, due to the fact that its neurons are able to secrete neuroendocrine transmitters (liberins and statins) that stimulate or inhibit the production of hormones from the adenohypophysis [3,5]. Suppression of the functional activity of the hypothalamus leads to a violation of drinking and eating behavior [9]. Considering all of the above, the task of this study was to study the role of various nuclei of the hypothalamus in the implementation of the drinking skill developed.…”

Section: Introductionmentioning

confidence: 99%

Participation of Various Nuclei of the Hypothalamus in the Implementation of the Drinking Skill Developed

Baghirova¹

2021

BJSTR

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In order to study the role of various nuclei of the hypothalamus in the implementation of the drinking skill developed electrostimulation and temporary shutdown were performed supraoptic (SO), ventromedial (VMH) and medial-mamillary (MM) nuclei of the hypothalamus. The registration of the amount of consumed water showed the following: electrostimulation of SO, unlike VMH and MM of hypothalamic nuclei caused additional water consumption in comparison with the background. The application of novocaine in SO led to a significant decrease in the amount of water consumed, which decreased for the duration of the action of novocaine (40-50 minutes) and amounted to 60-70 ml instead of 120 in the norm. Bilateral novocaine blockade of SO led to a complete inhibition of the performance of the developed drinking skill. Thus, the results of the studies carried out on electrical stimulation and temporary switching off of the SO suggest that the osmoreceptors of the SO of the anterior hypothalamus play a certain role in the processes of the formation of thirst.

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“…The metabolic phenotyping of obese people is crucial in understanding the pathophysiology of metabolic disorders and is important for identifying high-risk groups and optimizing the prevention strategy for cardiometabolic diseases in the pubertal period (Filatova et al 2018). Obesity with pink striae is the leading symptom of the hypothalamic syndrome of puberty it is associated with dysfunction of the hypothalamus and emerging hormonal-metabolic disorders (Nikonova et al 2019;Stroyev et al 2019). Hypothalamic syndrome is a consequence of primary immaturity of hypothalamic structures (Borovska-Stryuk 2018) or secondary dysfunction caused by structural and functional damage to the hypothalamus (Bereket et al 2012;Bereket et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Hormonal Changes in the Hypothalamus-Pituitary-Adrenal- Gonads System in Young Men With Hypothalamic Obesity

2020

jcr

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Purpose of the study -to analyze the frequency and severity of hormonal changes in the hypothalamus-pituitary-adrenal-gonads system in young men with hypothalamic syndrome and alimentary-constitutional obesity. Materials and methods. We examined 340 males (mean age 21.27±2.44 years). Examined patients were divided into the following groups: Group I -hypothalamic syndrome of the late puberty (n=84); Group II -constitutional-exogenous obesity of the late puberty (n=20); Group III -hypothalamic syndrome of mature age (n=158); Group IV -constitutional-exogenous obesity of mature age (n=78). Results. In groups of patients with hypothalamic syndrome, a higher level of morning cortisol (р<0.05), evening cortisol (р<0.05), prolactin (р<0.05), luteinizing hormone (р<0.05), follicle-stimulating hormone (р<0.05) than in patients with constitutionally-exogenous obesity. In groups of patients with hypothalamic syndrome, lower testosterone levels were recorded than in patients with constitutionally-exogenous obesity (р<0.05). Violation of the daily rhythm of cortisol production was more common in patients with hypothalamic syndrome than in constitutionally-exogenous obesity (р<0.05). In groups of patients with hypothalamic syndrome, the incidence of high prolactin was higher than in groups of patients with constitutionally-exogenous obesity (p<0.05). In groups of patients with signs of hypothalamic syndrome, low testosterone levels were more common than with constitutionally exogenous obesity (p<0.05). Conclusion. The data obtained indicate a higher functional activity of the hypothalamus-pituitary-adrenal axis and lower functional activity of the hypothalamus-pituitary-gonads axis in patients with hypothalamic syndrome in comparison with patients with constitutionally-exogenous obesity.Keywords: hypothalamus dysfunction, hypothalamic obesity, obesity in adolescents, hormonal disorders in adolescents, hormonal disorders in young men

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Hypothalamic Syndrome. The Role of the Hypothalamus in the Formation of Eating Behavior and Obesity

Cited by 5 publications

References 13 publications

Markers of endothelial dysfunction in adolescent and young patients with hypothalamic syndrome

Markers of endothelial dysfunction in adolescent and young patients with hypothalamic syndrome

Participation of Various Nuclei of the Hypothalamus in the Implementation of the Drinking Skill Developed

Hormonal Changes in the Hypothalamus-Pituitary-Adrenal- Gonads System in Young Men With Hypothalamic Obesity

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