Hypothermia after cardiac arrest should be further evaluated—A systematic review of randomised trials with meta-analysis and trial sequential analysis

Nielsen, Niklas; Friberg, Hans; Gluud, Christian; Herlitz, Johan; Wetterslev, Jørn

doi:10.1016/j.ijcard.2010.06.008

Cited by 154 publications

(108 citation statements)

References 65 publications

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“…4 Although a Cochrane review supports these guidelines, 5 some investigators have suggested a need for additional trials to confirm or refute the current treatment strategy. [6][7][8] Furthermore, one trial showed that fever developed in many patients in the standardtreatment group. 3 It is therefore unclear whether the reported treatment effect was due to hypothermia or to the prevention of fever, which is associated with a poor outcome.…”

mentioning

confidence: 99%

Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest

Nielsen

Wetterslev

Cronberg³

et al. 2013

N Engl J Med

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mentioning

confidence: 99%

Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest

Nielsen

Wetterslev

Cronberg³

et al. 2013

N Engl J Med

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2,465

1,864

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“…32 There are no standard recommendations on the site of temperature measurement or methods of temperature reduction. In practice choice of site of measurement is variable 31,33 and cooling interventions are systemic. Pharmacological intervention with paracetamol is the most common first line treatment, followed by a variety of physical systemic cooling interventions which include cooling blankets, ice packs and fanning.…”

Section: 25mentioning

confidence: 99%

“…However, in global (whole body) ischaemia, following cardiac arrest, therapeutic hypothermia is considered to improve outcome, specifically with return of circulation after ventricular fibrillation, [30][31][32] although doubts have been raised over the quality of the evidence. 33 Therefore, during the protocol review process, we were asked to include the cardiac arrest literature on head cooling in our searches because this could contribute information about how effective these interventions are in reducing temperature, and on their ease of use and side effects. Studies in cardiac arrest were not relevant for assessment of functional outcome in this review.…”

mentioning

confidence: 99%

Systematic review of head cooling in adults after traumatic brain injury and stroke

Harris

Andrews²,

Murray³

et al. 2012

Health Technol Assess

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An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service' . The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects. First is the commissioned route. Suggestions for research...

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“…Several meta-analyses have however produced inconsistent results (table 3). While Holzer et al calculated that six patients have to be treated by TH to save one more life (95% CI 4-13, p < 0,05), Nielsens meta-analysis pointed out to some gaps in the evidence (Nielsen et al, 2010 Table 3. The results of the analyses of the registries and metaanalyses.…”

Section: Wwwintechopencommentioning

confidence: 99%

Therapeutic Hypothermia in Cardiac Arrest Survivors

Škulec¹

2012

Coronary Interventions

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Hypothermia after cardiac arrest should be further evaluated—A systematic review of randomised trials with meta-analysis and trial sequential analysis

Cited by 154 publications

References 65 publications

Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest

Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest

Systematic review of head cooling in adults after traumatic brain injury and stroke

Therapeutic Hypothermia in Cardiac Arrest Survivors

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