Hypothermia due to limbic system involvement and longitudinal myelitis in a case of Japanese encephalitis: a case report from India

Narayanan, Santhosh; Thulaseedharan, NK; Subramaniam, Gomathy; Panarkandy, Geetha; Shameer, VK; Narayanan, Arathi

doi:10.2147/ijgm.s129829

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…GBS, transverse myelitis (<3 segments), longitudinally extensive transverse myelitis (⩾3 segments), acute disseminated encephalomyelitis, dystonic storm, have all been reported neurological complications in patients with JE. 95 – 99 Furthermore, a case of N-methyl d-aspartate receptor encephalitis secondary to JE has also been reported pointing toward the possibility of secondary autoimmune events. 100 A case of JE mimicking poliomyelitis and presenting with primary respiratory failure has also been reported.…”

Section: Flaviviridae Familymentioning

confidence: 99%

“…However, involvement of the limbic system can present with hypothermia as reported in an 18-year-old patient with JE with bilateral lateral rectus palsy and asymmetric flaccid paresis of the four limbs. 98 A detailed ophthalmologic examination is necessary in patients with suspected JEV infection, highlighted by several cases of ischemic maculopathy, chorioretinitis, and retinal hemorrhages. 103 – 105 …”

Section: Flaviviridae Familymentioning

confidence: 99%

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Neuroinvasion of emerging and re-emerging arboviruses: A scoping review

Srichawla,

Manan,

Kipkorir

et al. 2024

SAGE Open Medicine

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Background: Arboviruses are RNA viruses and some have the potential to cause neuroinvasive disease and are a growing threat to global health. Objectives: Our objective is to identify and map all aspects of arbovirus neuroinvasive disease, clarify key concepts, and identify gaps within our knowledge with appropriate future directions related to the improvement of global health. Methods: Sources of Evidence: A scoping review of the literature was conducted using PubMed, Scopus, ScienceDirect, and Hinari. Eligibility Criteria: Original data including epidemiology, risk factors, neurological manifestations, neuro-diagnostics, management, and preventive measures related to neuroinvasive arbovirus infections was obtained. Sources of evidence not reporting on original data, non-English, and not in peer-reviewed journals were removed. Charting Methods: An initial pilot sample of 30 abstracts were reviewed by all authors and a Cohen’s kappa of κ = 0.81 (near-perfect agreement) was obtained. Records were manually reviewed by two authors using the Rayyan QCRI software. Results: A total of 171 records were included. A wide array of neurological manifestations can occur most frequently, including parkinsonism, encephalitis/encephalopathy, meningitis, flaccid myelitis, and Guillain-Barré syndrome. Magnetic resonance imaging of the brain often reveals subcortical lesions, sometimes with diffusion restriction consistent with acute ischemia. Vertical transmission of arbovirus is most often secondary to the Zika virus. Neurological manifestations of congenital Zika syndrome, include microcephaly, failure to thrive, intellectual disability, and seizures. Cerebrospinal fluid analysis often shows lymphocytic pleocytosis, elevated albumin, and protein consistent with blood-brain barrier dysfunction. Conclusions: Arbovirus infection with neurological manifestations leads to increased morbidity and mortality. Risk factors for disease include living and traveling in an arbovirus endemic zone, age, pregnancy, and immunosuppressed status. The management of neuroinvasive arbovirus disease is largely supportive and focuses on specific neurological complications. There is a need for therapeutics and currently, management is based on disease prevention and limiting zoonosis.

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Section: Flaviviridae Familymentioning

confidence: 99%

Section: Flaviviridae Familymentioning

confidence: 99%

Neuroinvasion of emerging and re-emerging arboviruses: A scoping review

Srichawla,

Manan,

Kipkorir

et al. 2024

SAGE Open Medicine

View full text Add to dashboard Cite

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Myelitis with flaccid paralysis due to Japanese encephalitis: case report and review of the literature

et al. 2022

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Background Japanese encephalitis is an arthropod-borne zoonotic flavivirus infection endemic to tropical and subtropical Asia. A minority of infections leads to a symptomatic course, but affected patients often develop life-threatening encephalitis with severe sequelae. Literature review Myelitis with flaccid paralysis is a rare complication of Japanese Encephalitis, which—according to our literature search—was reported in 27 cases, some of which were published as case reports and others as case series. Overall, there is a broad clinical spectrum with typically asymmetric manifestation and partly severe motor sequelae and partly mild courses. Lower limb paralysis appears to be more frequent than upper limb paralysis. An encephalitic component is not apparent in all cases Case presentation We herein add the case of a 29 year-old female who developed encephalitis and myelitis with flaccid paralysis during a long-time stay in Indonesia. Diagnostic workup in Indonesia did not clearly reveal an underlying cause. Upon clinical stabilization, the patient was evacuated to her home country Germany, where further diagnostics confirmed Japanese encephalitis virus as the causative agent. The patient has partly recovered, but still suffers from residual paralysis of the upper limb. Conclusion Flaccid paralysis is a rare, and likely underdiagnosed complication of Japanese encephalitis, which, to the best of our knowledge, has never been diagnosed outside endemic areas before.

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Dengue Virus Infection of Blood–Brain Barrier Cells: Consequences of Severe Disease

et al. 2019

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More than 500 million people worldwide are infected each year by any of the four-dengue virus (DENV) serotypes. The clinical spectrum caused during these infections is wide and some patients may develop neurological alterations during or after the infection, which could be explained by the cryptic neurotropic and neurovirulent features of flaviviruses like DENV. Using in vivo and in vitro models, researchers have demonstrated that DENV can affect the cells from the blood–brain barrier (BBB) in several ways, which could result in brain tissue damage, neuronal loss, glial activation, tissue inflammation and hemorrhages. The latter suggests that BBB may be compromised during infection; however, it is not clear whether the damage is due to the infection per se or to the local and/or systemic inflammatory response established or activated by the BBB cells. Similarly, the kinetics and cascade of events that trigger tissue damage, and the cells that initiate it, are unknown. This review presents evidence of the BBB cell infection with DENV and the response established toward it by these cells; it also describes the consequences of this response on the nervous tissue, compares these evidence with the one reported with neurotropic viruses of the Flaviviridae family, and shows the complexity and unpredictability of dengue and the neurological alterations induced by it. Clinical evidence and in vitro and in vivo models suggest that this virus uses the bloodstream to enter nerve tissue where it infects the different cells of the neurovascular unit. Each of the cell populations respond individually and collectively and control infection and inflammation, in other cases this response exacerbates the damage leaving irreversible sequelae or causing death. This information will allow us to understand more about the complex disease known as dengue, and its impact on a specialized and delicate tissue like is the nervous tissue.

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Hypothermia due to limbic system involvement and longitudinal myelitis in a case of Japanese encephalitis: a case report from India

Cited by 3 publications

References 8 publications

Neuroinvasion of emerging and re-emerging arboviruses: A scoping review

Neuroinvasion of emerging and re-emerging arboviruses: A scoping review

Myelitis with flaccid paralysis due to Japanese encephalitis: case report and review of the literature

Dengue Virus Infection of Blood–Brain Barrier Cells: Consequences of Severe Disease

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