Hypothermia for acute ischaemic stroke

Wu, Tzu‐Ching; Grotta, James C.

doi:10.1016/s1474-4422(13)70013-9

Cited by 182 publications

(140 citation statements)

References 70 publications

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“…Clinical trials evaluating mild TH aim for optimum target temperatures between 33°C and 35°C. 11 In both the numeric and in vitro models, however, temperatures were kept constant to 37°C proximal to the inlet of the balloon catheter system, which neglects the in vivo recirculation effect of already cooled blood. The latter may add to a further decrease in blood temperature distal to the balloon catheter system in an in vivo application.…”

Section: Discussionmentioning

confidence: 99%

Combined Selective Cerebral Hypothermia and Mechanical Artery Recanalization in Acute Ischemic Stroke: In Vitro Study of Cooling Performance

Cattaneo

Schumacher

Wolfertz

et al. 2015

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Therapeutic hypothermia represents a promising neuroprotective treatment for patients with ischemic stroke. Selective, intracarotid blood cooling may initiate rapid and early brain hypothermia, reduce systemic effects, and allow combined endovascular mechanical thrombectomy. For this approach, a balloon cooling catheter system was designed and studied in vitro to optimize its cooling performance.

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Section: Discussionmentioning

confidence: 99%

Combined Selective Cerebral Hypothermia and Mechanical Artery Recanalization in Acute Ischemic Stroke: In Vitro Study of Cooling Performance

Cattaneo

Schumacher

Wolfertz

et al. 2015

AJNR Am J Neuroradiol

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“…The mechanism of SCII protection mainly involves reduced metabolism in the ischemic region, inhibition of the release of excitatory amino acids (mainly glutamic acid), relief of the inflammatory response, interruption of the apoptosis pathway, inhibition of free radical release, and relief of inflammatory edema (Wu and Grotta, 2013). The damage caused by low temperatures on the central nervous system may be due to the contraction of blood vessels in the spinal cord, higher blood viscosity, slower blood flow, appearance of the "no-reflow phenomenon" in the tiny blood vessels, and aggravation of the ischemia and hypoxia injury (Jia and Pollock, 1997).…”

Section: Discussionmentioning

confidence: 99%

Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury

Zhu

Zhao

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We evaluated changes in BAX and BCL2 expression levels after spinal cord ischemia/reperfusion injury (SCII) and hypothermia during operations in rats. Eighty rats were divided into four groups: Group A (N = 20, 18°C); Group B (N = 20, 28°C); Group C (N = 20, room temperature); and Group D (N = 20, sham operation control). Spinal cord ischemia was induced for 90 min. Hypothermia was induced 15 min before, and maintained during ischemia, followed by heating to normothermia for 30 min after reperfusion. Motor function of the lower limbs was evaluated according to the Tarlov score at 72 and 168 h. For each rat, spinal cord samples were taken at 6, 24, 72 h, and 1 week to evaluate the histopathological changes, neuronal 10491 BAX and BCL2 in spinal cord ischemia reperfusion injury rats ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 10490-10499 (2015) apoptosis, and BAX and BCL2 expression levels. Compared with normothermia, hypothermia significantly improved hind limb function; Group B achieved a higher score than Group A. Group D showed no neurologic deficiency, while the other groups showed various degrees. Group C exhibited greater neuronal apoptosis, higher BAX expression, but lower BCL2 expression than the other groups. Compared with Group A, BAX was expressed less and BCL2 more in Group B, and there was less apoptosis in Group B. Hypothermia preserves hind limb motor function and reduces neuronal death, thereby protecting rats from SCII. The spinal cord may be protected from SCII by inhibition of BAX and activation of BCL2. However, deep hypothermia may inhibit the expression of BCL2, resulting in a worse outcome than mild hypothermia.

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“…2 Recently, the feasibility and safety of TH in patients with acute ischemic stroke was proved in controlled studies, [3][4][5][6] and 2 multicenter, randomized clinical trials (EuroHYP-1 and ICTuS 2/3) 7, 8 are currently underway to study its efficacy.…”

mentioning

confidence: 99%

Endovascular Cooling Catheter for Selective Brain Hypothermia: An Animal Feasibility Study of Cooling Performance

Cattaneo

Schumacher²,

Maurer³

et al. 2015

American Journal of Neuroradiology

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Hypothermia for acute ischaemic stroke

Cited by 182 publications

References 70 publications

Combined Selective Cerebral Hypothermia and Mechanical Artery Recanalization in Acute Ischemic Stroke: In Vitro Study of Cooling Performance

Combined Selective Cerebral Hypothermia and Mechanical Artery Recanalization in Acute Ischemic Stroke: In Vitro Study of Cooling Performance

Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury

Endovascular Cooling Catheter for Selective Brain Hypothermia: An Animal Feasibility Study of Cooling Performance

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