Hypothermia

Peiris, Alan N.; Jaroudi, Sarah; Gavin, Meredith

doi:10.1001/jama.2018.0749

Cited by 19 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypothermia is defined as a decrease in body temperature to less than 35 °C. Hypothermia is classified as mild (32–35 °C), moderate (28–32 °C), severe (25–28 °C), and profound (<24 °C) based on severity [ 64 ]. Given that MHT affects cell growth and survival, C2C12 cells were cooled to 32 °C for 3, 6, and 9 h. The results showed that MHT induced autophagy and mitophagy and upregulated O-GlcNAcylation in C2C12 cells, similar to the response to CS in vivo ( Supplementary Figure S1A,B ).…”

Section: Resultsmentioning

confidence: 99%

O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis

Cao

Zhang

et al. 2022

IJMS

View full text Add to dashboard Cite

Cold stress disturbs cellular metabolic and energy homeostasis, which is one of the causes of stress-induced illnesses. O-GlcNAcylation is a nutrient-sensing pathway involved in a myriad of cellular processes. It plays a key role in metabolic homeostasis. Nevertheless, a specific sensing mechanism linking skeletal muscle to O-GlcNAcylation in cold stress is unknown. In this study, O-GlcNAcylation of SIRT1 was targeted to explore the mechanism of skeletal muscle adaptation to cold stress. Ogt mKO aggravated skeletal muscle fibrosis induced by cold stress. At the same time, Ogt gene deletion accelerated the homeostasis imbalance and oxidative stress of skeletal muscle mitochondria induced by cold stress. In vitro results showed that inhibition of SIRT1’s O-GlcNAcylation accelerated mild hypothermia induced mitochondrial homeostasis in mouse myogenic cells (C2C12 cells). However, overexpression of SIRT1’s O-GlcNAcylation improved the above phenomena. Thus, these results reveal a protective role of OGT-SIRT1 in skeletal muscle’s adaptation to cold stress, and our findings will provide new avenues to combat stress-induced diseases.

show abstract

Section: Resultsmentioning

confidence: 99%

O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis

Cao

Zhang

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…It has been well established that torpor bouts last longer at lower temperatures. For normal humans, a T b lower than 35°C leads to net loss of body heat and dysfunction in vital organs (Peiris, Jaroudi & Gavin, 2018). The brain can withstand temperatures lowered to 5–10°C, but can be damaged by temperatures below 5°C (Behringer et al ., 2003).…”

Section: Discussionmentioning

confidence: 99%

Human torpor: translating insights from nature into manned deep space expedition

et al. 2020

View full text Add to dashboard Cite

During a long‐duration manned spaceflight mission, such as flying to Mars and beyond, all crew members will spend a long period in an independent spacecraft with closed‐loop bioregenerative life‐support systems. Saving resources and reducing medical risks, particularly in mental heath, are key technology gaps hampering human expedition into deep space. In the 1960s, several scientists proposed that an induced state of suppressed metabolism in humans, which mimics ‘hibernation’, could be an ideal solution to cope with many issues during spaceflight. In recent years, with the introduction of specific methods, it is becoming more feasible to induce an artificial hibernation‐like state (synthetic torpor) in non‐hibernating species. Natural torpor is a fascinating, yet enigmatic, physiological process in which metabolic rate (MR), body core temperature (Tb) and behavioural activity are reduced to save energy during harsh seasonal conditions. It employs a complex central neural network to orchestrate a homeostatic state of hypometabolism, hypothermia and hypoactivity in response to environmental challenges. The anatomical and functional connections within the central nervous system (CNS) lie at the heart of controlling synthetic torpor. Although progress has been made, the precise mechanisms underlying the active regulation of the torpor–arousal transition, and their profound influence on neural function and behaviour, which are critical concerns for safe and reversible human torpor, remain poorly understood. In this review, we place particular emphasis on elaborating the central nervous mechanism orchestrating the torpor–arousal transition in both non‐flying hibernating mammals and non‐hibernating species, and aim to provide translational insights into long‐duration manned spaceflight. In addition, identifying difficulties and challenges ahead will underscore important concerns in engineering synthetic torpor in humans. We believe that synthetic torpor may not be the only option for manned long‐duration spaceflight, but it is the most achievable solution in the foreseeable future. Translating the available knowledge from natural torpor research will not only benefit manned spaceflight, but also many clinical settings attempting to manipulate energy metabolism and neurobehavioural functions.

show abstract

“…The risk factors for hypothermia (body temperature <95 °F) are exposure to cold temperatures, poor physical conditioning, exhaustion, lack of sufficient warm protective clothing, or predisposing health conditions (e.g., diabetes, hypothyroidism, hypertension, trauma, or consumption of drugs or illicit alcohol). [ 68,69 ] Hypothermia leads to symptoms such as shivering, slow pulse and breathing, slurred speech, exhaustion, and lack of coordination. [ 70–72 ] Prolonged exposure to cold stress can result in frost bite, trench foot, and chilblains.…”

Section: Wearables For Occupational Safety Monitoringmentioning

confidence: 99%

Trends in Workplace Wearable Technologies and Connected‐Worker Solutions for Next‐Generation Occupational Safety, Health, and Productivity

Patel

Chesmore

Legner

et al. 2021

Advanced Intelligent Systems

119

View full text Add to dashboard Cite

The workplace influences the safety, health, and productivity of workers at multiple levels. To protect and promote total worker health, smart hardware, and software tools have emerged for the identification, elimination, substitution, and control of occupational hazards. Wearable devices enable constant monitoring of individual workers and the environment, whereas connected worker solutions provide contextual information and decision support. Here, the recent trends in commercial workplace technologies to monitor and manage occupational risks, injuries, accidents, and diseases are reviewed. Workplace safety wearables for safe lifting, ergonomics, hazard identification, sleep monitoring, fatigue management, and heat and cold stress are discussed. Examples of workplace productivity wearables for asset tracking, augmented reality, gesture and motion control, brain wave sensing, and work stress management are given. Workplace health wearables designed for work‐related musculoskeletal disorders, functional movement disorders, respiratory hazards, cardiovascular health, outdoor sun exposure, and continuous glucose monitoring are shown. Connected worker platforms are discussed with information about the architecture, system modules, intelligent operations, and industry applications. Predictive analytics provide contextual information about occupational safety risks, resource allocation, equipment failure, and predictive maintenance. Altogether, these examples highlight the ground‐level benefits of real‐time visibility about frontline workers, work environment, distributed assets, workforce efficiency, and safety compliance.

show abstract

Hypothermia

Cited by 19 publications

References 0 publications

O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis

O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis

Human torpor: translating insights from nature into manned deep space expedition

Trends in Workplace Wearable Technologies and Connected‐Worker Solutions for Next‐Generation Occupational Safety, Health, and Productivity

Contact Info

Product

Resources

About