Hypothermic hyperbaric lung preservation for twenty-four hours with replantation

Garzon, Antonio A.; Cheng, Charles; Pangan, Jose; Karlson, Karl E.

doi:10.1016/s0022-5223(19)42944-9

Cited by 33 publications

(1 citation statement)

References 7 publications

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“…Oxygenation capacity, by contrast, has been reported to be better preserved in animals surviving transplantation (6,14,20,26). Minimal arterial oxygen pressures p02 during the first days postoperatively that would allow for survival were cletermined around 60 torr on room air (14,26).…”

Section: Discussionmentioning

confidence: 99%

Improved Lung Preservation using Euro-Collins Solution for Flush-perfusion

Haverich

Aziz

Scott

et al. 1986

Thorac cardiovasc Surg

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Satisfactory extended preservation of the lung has been difficult to obtain. This study investigated the influence of different total volumes and flow rates during flush-perfusion of the lung, and their effect on pulmonary artery pressure, flow distribution, regional lung temperature and functional performance of the lungs following transplantation after 24 hours. Fifteen mongrel dogs served as donors of the heart and lung block. Cold modified Euro-Collins solution was used as flush perfusate. Pulmonary artery and perfusion-line pressures were measured. The regional lung temperature was measured at one minute intervals with 5 myocardial temperature probes. Flow distribution was determined with micro-aggregated albumin labelled with Technetium 99. The heart-lung block was harvested, the right lung removed, and samples taken for gamma-counting. The left lung was stored in cold Euro-Collins solution and then transplanted. The inspired oxygen fraction (FiO2) was set at 0.4 and was kept constant throughout the procedure and the entire postoperative course. There were 3 groups of 5 animals each. In group A, the flush perfusate was administered at a total volume of 20 cc/kg over a period of 6 minutes. In group B the same volume of perfusate was administered at a pulmonary artery pressure (PAP) of 18 to 20 mmHg, resulting in a considerably shorter perfusion time (1.3 minutes). In group C 60 cc/kg of perfusate were given at the same flow rate as in group B, also resulting in PAP of 18 to 20 mmHg, but the perfusion time was increased to 4 minutes. Thus, groups B and C investigated the effect of increased pressure and volume of perfusate, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

Improved Lung Preservation using Euro-Collins Solution for Flush-perfusion

Haverich

Aziz

Scott

et al. 1986

Thorac cardiovasc Surg

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An evaluation of the tolerance of the autotransplanted canine lung against warm ischemia

Yamazaki

Wada

Aoki

et al. 1989

The Japanese Journal of Surgery

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Left lung autotransplantation was performed in mongrel dogs to examine the limitation of tolerance of the deflated lung against warm ischemia in a warm ischemic time (WIT) range of 60-360 minutes. The animals were divided into the 4 following groups according to the duration of WIT and the use of heparin: Group 1; WIT 60-120 min., heparin (-), Group 2; WIT 120-240 min., heparin (+), Group 3; WIT 240-360 min., heparin (+), and Group 4; WIT 240-360 min., heparin (-). All the Group 1 animals tolerated a right pulmonary artery ligation on the 6th postoperative day, but some of the Group 2 animals died immediately after the reimplantation due to pulmonary edema. All the Groups 3 and 4 animals died. The PaO2 values during the right pulmonary artery occlusion, immediately after the reimplantation, correlated well with the survival of the animals. The maximum tolerable WIT of the deflated dog lung was considered to be 120 minutes.

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