Hypothermie unter Olanzapin

Kreuzer, Peter; Landgrebe, Michael; Wittmann, Markus; Hajak, Göran; Schecklmann, Martin; Poeppl, Timm B.; Langguth, Berthold

doi:10.1007/s00115-011-3310-y

Cited by 12 publications

(6 citation statements)

References 32 publications

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“…The increased energy storage induced by olanzapine was extensively considered a result of both increased energy intake (such as hyperphagia) [43], [44] and reduced energy expenditure (such as decreased thermogenesis) [45], [46]. Our results showed that olanzapine treatment increased food intake by 21.2%, enhanced fat accumulation by 52.1%, and reduced brown fat amount by 39.3%, when compared with the control group.…”

Section: Discussionmentioning

confidence: 50%

Metformin and Berberine Prevent Olanzapine-Induced Weight Gain in Rats

Young

Ehli

et al. 2014

PLoS ONE

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Olanzapine is a first line medication for the treatment of schizophrenia, but it is also one of the atypical antipsychotics carrying the highest risk of weight gain. Metformin was reported to produce significant attenuation of antipsychotic-induced weight gain in patients, while the study of preventing olanzapine-induced weight gain in an animal model is absent. Berberine, an herbal alkaloid, was shown in our previous studies to prevent fat accumulation in vitro and in vivo. Utilizing a well-replicated rat model of olanzapine-induced weight gain, here we demonstrated that two weeks of metformin or berberine treatment significantly prevented the olanzapine-induced weight gain and white fat accumulation. Neither metformin nor berberine treatment demonstrated a significant inhibition of olanzapine-increased food intake. But interestingly, a significant loss of brown adipose tissue caused by olanzapine treatment was prevented by the addition of metformin or berberine. Our gene expression analysis also demonstrated that the weight gain prevention efficacy of metformin or berberine treatment was associated with changes in the expression of multiple key genes controlling energy expenditure. This study not only demonstrates a significant preventive efficacy of metformin and berberine treatment on olanzapine-induced weight gain in rats, but also suggests a potential mechanism of action for preventing olanzapine-reduced energy expenditure.

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Section: Discussionmentioning

confidence: 50%

Metformin and Berberine Prevent Olanzapine-Induced Weight Gain in Rats

Young

Ehli

et al. 2014

PLoS ONE

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“…This is the twelfth reported patient with olanzapine-induced hypothermia and the youngest pediatric patient with olanzapine-induced hypothermia described in the literature (PubMed Search for olanzapine and hypothermia 13.09.2011) (see Table 1) [5][6][7][8][9][12][13][14][15][16]. According to the literature, the risk of hypothermia is highest following initiation of the drug or after an increase in dosage.…”

Section: Literature Reviewmentioning

confidence: 86%

“…Metabolism of olanzapine is via CYP 1A2 pathways, with no relevant genetic polymorphisms currently on record [7,8]. It is known that in normal humans there is a balance between the down-regulation of the body temperature by dopamine and the up-regulation of the body temperature by serotonin.…”

Section: Discussionmentioning

confidence: 99%

“…Major side effects of olanzapine and other second-generation antipsychotics, like risperdone, quetiapine, aripipazole, paliperidone and ziprasidone are temperature dysregulation (mostly hyper-thermia, less often hypothermia) and the neuroleptic malignant syndrome, a life threatening event. Other side effects seen by neuroleptic drugs are include sedation, weight gain, hyperglycemia, orthostatic hypotension, dizziness, constipation, urinary retention, discoloration of teeth and dental problems and occasionally seizures [3,[5][6][7][8][9]. Drug may increase triglyceride, cholesterol and transaminase levels [10].…”

Section: Introductionmentioning

confidence: 99%

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Olanzapine-associated hypothermia in an adolescent anorexic girl

Docx¹,

Simons²,

Ramet³

et al. 2012

OJCD

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This is a 12th case report on olanzapine induced hypothermia and based on the results of literature search, by far is the youngest case ever is reported. The hypothermia occurred during the refeeding phase, despite a weight gain since increasing the dosage from 5 mg to 7.5 mg olanzapine. Our recent literature search found 11 published cases of olanzapine treatment associated with hypothermia. Olanzapine acts on serotonin or dopamin receptors and has antagonistic properties on histaminergic, muscarinic and <i>α</i>-adrenergic receptors. Olanzapine mediates the hypothermic effect through antagonism at receptors other than dopamine

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“…De plus, une revue de la base nationale de pharmacovigilance française menée en 2013, identifie les antipsychotiques comme les psychotropes les plus pourvoyeurs d'hypothermie (3). Dans notre cas, nous retrouvons plusieurs facteurs de risque d'hypothermie induite par les antipsychotiques identifiés dans la littérature : l'utilisation conjointe d'une benzodiazépine (2,4), qui altère la thermorégulation par le bais de la transmission GABAergique (5), l'hospitalisation en chambre de soins intensifs, nécessitant un habillement sommaire (1) et la présence d'air conditionné (2), le choix de la Rispéridone, antipsychotique le plus fréquemment incriminé dans les cas d'hypothermie (1), et enfin l'association de plusieurs antipsychotiques (6). En effet, la cinétique de l'épisode plaide pour une action additive des différents antipsychotiques, sans qu'une molécule ne puisse être incriminée à elle seule.…”

Section: Discussionunclassified